BDBM99471 US8497274, 32
SMILES Fc1ccc(Oc2ccc3nc(NC(=O)C4CC4)sc3c2C#N)cc1NC(=O)Cc1cccc(c1)C(F)(F)F
InChI Key InChIKey=OJFKUJDRGJSAQB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 28 hits for monomerid = 99471
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: <300nMAssay Description:MEK phosphorylation inhibition activity.More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 3(Homo sapiens (Human))
Ningxia Medical University
Curated by ChEMBL
Ningxia Medical University
Curated by ChEMBL
Affinity DataKd: 105nMAssay Description:Inhibition of human wild type RIPK3 (M1 to Q307) expressed in bacterial system by kinomescan assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged B-Raf V600E mutant expressed in baculovirus expression system using Z'-LYTE Ser/Thr3 peptide as...More data for this Ligand-Target Pair
3D Structure (crystal)TargetMitogen-activated protein kinase kinase kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged MEKK1 (unknown origin) expressed in baculovirus system using MBP as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 66nMAssay Description:Inhibition of N-terminal His-6-tagged Aurora kinase B (unknown origin) expressed in baculovirus system after 60 minsMore data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 580nMAssay Description:Inhibition of CDK2/CycA (unknown origin) using histone H1 as substrate after 20 minsMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 790nMAssay Description:Inhibition of CDK1/CycB (unknown origin) using histone H1 as substrate after 20 minsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged ERK1 expressed in baculovirus system (unknown origin) using MBP as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CK1delta (unknown origin) using CK1tide as substrate after 20 minsMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CHK1 (unknown origin) using alpha-casein as substrate after 20 minsMore data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of C-terminal FLAG-tagged IKK beta (unknown origin) expressed in baculovirus system using IkappaBalpha as substrate after 40 minsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Insulin receptor (unknown origin) using biotinylated poly-Glu-Tyr (4:1) as substrate preincubated for 5 mins measured after 12 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of c-Met receptor (unknown origin) using biotinylated poly-Glu-Tyr (4:1) as substrate preincubated for 5 mins measured after 12 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal peptide (DYKDDDD)-tagged EGFR (unknown origin) expressed in baculovirus system using biotinylated poly-Glu-Tyr (4:1) as subs...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor subunit B(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of PDGFR beta (unknown origin) using biotinylated poly-Glu-Tyr (4:1) as substrate preincubated for 5 mins measured after 12 hrsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor subunit A(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 610nMAssay Description:Inhibition of PDGFR alpha (unknown origin) using biotinylated poly-Glu-Tyr (4:1) as substrate preincubated for 5 mins measured after 12 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 8.30nMAssay Description:Inhibition of N-terminal FLAG-tagged wild type BRAF (unknown origin) expressed in baculovirus system using GST-MEK1(K96R) as substrate after 20 minsMore data for this Ligand-Target Pair
TargetHeat shock factor protein 1(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
TargetHeat shock factor protein 1(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Inhibition of N-terminal 6x-His-tagged BRAF kinase domain (unknown origin) expressed in baculovirus infected Sf9 insect cells co-expressing mouse p50...More data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:Inhibition of N-terminal 6x-His-tagged BRAF V600E mutant (unknown origin) expressed in baculovirus infected Sf9 insect cells co-expressing mouse p50c...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human full length GST-tagged BRAF expressed in baculovirus expression systemMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of 6-amino-9-(2-((4-((2-((6-((5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)carbamoyl)quinolin-2-yl)oxy)ethyl)amino)-...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human GST-tagged BRAF V600E mutant expressed in baculovirus expression systemMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Ningxia Medical University
Curated by ChEMBL
Ningxia Medical University
Curated by ChEMBL
Affinity DataKd: 480nMAssay Description:Binding affinity to wild-type human partial length RIPK1 (M1 to K305 residues) expressed in bacterial expression system after 1 hr by quantitative PC...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 3(Homo sapiens (Human))
Ningxia Medical University
Curated by ChEMBL
Ningxia Medical University
Curated by ChEMBL
Affinity DataKd: 105nMAssay Description:Binding affinity to wild-type human partial length RIPK3 (M1 to Q307 residues) expressed in bacterial expression system after 1 hr by quantitative PC...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Ningxia Medical University
Curated by ChEMBL
Ningxia Medical University
Curated by ChEMBL
Affinity DataKd: 480nMAssay Description:Inhibition of human wild type RIPK1 (M1 to K305) expressed in bacterial system by kinomescan assayMore data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:Inhibition of recombinant wild type full length human GST-tagged B-Raf expressed in baculovirus expression system using Z'-LYTE Ser/Thr3 peptide as s...More data for this Ligand-Target Pair