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Found 3 Enz. Inhib. hit(s) with Target = 'Hydroxysteroid 11-beta dehydrogenase 1'
TargetHydroxysteroid 11-beta dehydrogenase 1(Canis familiaris)
Amgen

Curated by ChEMBL
LigandPNGBDBM50273458((5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-...)
Affinity DataKi:  12nMAssay Description:Inhibition of dog recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxysteroid 11-beta dehydrogenase 1(Canis familiaris)
Amgen

Curated by ChEMBL
LigandPNGBDBM50273458((5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-...)
Affinity DataIC50:  45nMAssay Description:Inhibition of dog 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxysteroid 11-beta dehydrogenase 1(Canis familiaris)
Amgen

Curated by ChEMBL
LigandPNGBDBM50392216(CHEMBL2153191 | US8673938, 7)
Affinity DataIC50:  3.77E+3nMAssay Description:Inhibition of N-terminal His6-tagged full length dog 11betaHSD1 expressed in baculovirus infected cells using cortisone as substrate after 25 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed