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Found 25 Enz. Inhib. hit(s) with Target = '4-hydroxy-2-oxoglutarate aldolase, mitochondrial'
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267947((3aR,5R,6S,7R,7aR)-5- ((cyclopentylamino)methyl)-2...)
Affinity DataKi:  0.600nM ΔG°:  -52.6kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267944((3aR,5R,6S,7R,7aR)-5- ((cyclopropylamino)methyl)-2...)
Affinity DataKi:  1.30nM ΔG°:  -50.7kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267946((3aR,5R,6S,7R,7aR)-5- ((cyclobutylamino)methyl)-2-...)
Affinity DataKi:  1.40nM ΔG°:  -50.5kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267936(((3aR,5R,6S,7R,7aR)-6,7-dihydroxy- 2-(methylamino)...)
Affinity DataKi:  2.70nM ΔG°:  -48.9kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267938((3aR,5R,6S,7R,7aR)-2- (methylamino)-5- ((methylami...)
Affinity DataKi:  2.80nM ΔG°:  -48.8kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267964((3aR,5R,6S,7R,7aR)-5-(((2- hydroxyethyl)amino)meth...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267943((3aR,5R,6S,7R,7aR)-5-(((2- methoxyethyl)amino)meth...)
Affinity DataKi:  3.30nM ΔG°:  -48.4kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267941((3aR,5R,6S,7R,7aR)-5- ((ethylamino)methyl)-2- (met...)
Affinity DataKi:  3.70nM ΔG°:  -48.1kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267942((3aR,5R,6S,7R,7aR)-5- ((allylamino)methyl)-2- (met...)
Affinity DataKi:  3.80nM ΔG°:  -48.1kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267965(2-((((3aR,5R,6S,7R,7aR)-6,7- dihydroxy-2-(methylam...)
Affinity DataKi:  5.40nM ΔG°:  -47.2kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267937((3aR,5R,6S,7R,7aR)-2-(ethylamino)- 5-((isopropylam...)
Affinity DataKi:  5.40nM ΔG°:  -47.2kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267939((3aR,5R,6S,7R,7aR)-2-(ethylamino)- 5-((methylamino...)
Affinity DataKi:  5.60nM ΔG°:  -47.1kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267945((3aR,5R,6S,7R,7aR)-5- ((cyclopropylamino)methyl)-2...)
Affinity DataKi:  6nM ΔG°:  -46.9kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267963((3aR,5R,6S,7R,7aR)-5-(((3- hydroxypropyl)amino)met...)
Affinity DataKi:  6nM ΔG°:  -46.9kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267962((3aR,5R,6S,7R,7aR)-2- (methylamino)-5-(((tetrahydr...)
Affinity DataKi:  6.5nM ΔG°:  -46.7kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267966((3aR,5R,6S,7R,7aR)-5-(((1H-pyrazol- 3-yl)amino)met...)
Affinity DataKi:  6.80nM ΔG°:  -46.6kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267948((3aR,5R,6S,7R,7aR)-5- ((cyclohexylamino)methyl)-2-...)
Affinity DataKi:  9.30nM ΔG°:  -45.8kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267784(((3aR,5R,6S,7R,7aR)-6,7-dihydroxy- 2-(methylamino)...)
Affinity DataKi:  9.90nM ΔG°:  -45.7kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267968((3aR,5R,6S,7R,7aR)-5 (aminomethyl)-2-(ethylamino)-...)
Affinity DataKi:  11nM ΔG°:  -45.4kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267967((3aR,5R,6S,7R,7aR)-5-(((4- fluorobenzyl)oxy)methyl...)
Affinity DataKi:  25nM ΔG°:  -43.4kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM50160721(2-Oxo-heptanedioic acid | 2-oxoheptanedioic acid |...)
Affinity DataKi:  1.70E+5nMAssay Description:Inhibition of dihydrodipicolinate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM50229870(4-oxo-1,4-dihydropyridine-2,6-dicarboxylic acid | ...)
Affinity DataKi:  1.70E+5nMAssay Description:Inhibition of dihydrodipicolinate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM50411597(CHEMBL403480)
Affinity DataKi:  3.30E+5nMAssay Description:Inhibition of dihydrodipicolinate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM50411596(CHEMBL253062)
Affinity DataKi:  2.96E+6nMAssay Description:Inhibition of dihydrodipicolinate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM26116(CHEMBL284104 | Dipicolinate | pyridine carboxylate...)
Affinity DataKi:  1.10E+7nMAssay Description:Inhibition of dihydrodipicolinate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed