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Found 237 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase B-raf [416-766,V600E]'
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322521(5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...)
Affinity DataIC50:  0.800nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322528(5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...)
Affinity DataIC50:  1nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322529(5-[3-[4-(2-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...)
Affinity DataIC50:  1.10nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322521(5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...)
Affinity DataIC50:  1.40nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322521(5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...)
Affinity DataIC50:  1.5nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322533(5-[3-[5-(3-pyridyl)-1H-imidazol-2-yl]chroman-6-yl]...)
Affinity DataIC50: <4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322521(5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...)
Affinity DataIC50: <4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322542(5-[[(3R)-3-(4-phenyl-1H-imidazol-2-yl)-2,3-dihydro...)
Affinity DataIC50: <4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322541(5-[[(3S)-3-(4-phenyl-1H-imidazol-2-yl)-2,3-dihydro...)
Affinity DataIC50: <4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322540(5-[3-(5-phenyl-1H-pyrazol-3-yl)chroman-6-yl]oxy-3,...)
Affinity DataIC50: <4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322525(5-[3[4-(4-pyridyl)-1H-imidazol-2-yl]chroman-6-yl]o...)
Affinity DataIC50: <4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322518(5-[3-(1H-benzimidazol-2-yl)chroman-6-yl]oxy-3,4-di...)
Affinity DataIC50: <4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322528(5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...)
Affinity DataIC50: <4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322529(5-[3-[4-(2-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...)
Affinity DataIC50: <4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322530(5-[3-[5-(2-chlorophenyl)-1H-imidazol-2-yl]chroman-...)
Affinity DataIC50: <4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322531(5-[3-[5-(3-chlorophenyl)-1H-imidazol-2-yl]chroman-...)
Affinity DataIC50: <4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322532(5-[3-[4-(benzofuran-3-yl)-1H-imidazol-2-yl]chroman...)
Affinity DataIC50: <4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322535(5-[3-[5-(4-fluorophenyl)-1H-imidazol-2-yl]chroman-...)
Affinity DataIC50: <4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322536(5-[3-[5-(1,3-benzodioxol-5-yl)-1H-imidazol-2-yl]ch...)
Affinity DataIC50: <4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322521(5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...)
Affinity DataIC50: <4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322521(5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...)
Affinity DataIC50: <4nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM313753(US10167282, Compound TBAP-04)
Affinity DataIC50:  8nMAssay Description:Mutant BRAF WM266.4 Cells.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM313751(US10167282, Compound TBAP-02)
Affinity DataIC50:  12nMAssay Description:Mutant BRAF WM266.4 Cells.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM313750(US10167282, Compound TBAP-01)
Affinity DataIC50:  18nMAssay Description:Mutant BRAF WM266.4 Cells.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM313752(US10167282, Compound TBAP-03)
Affinity DataIC50:  19nMAssay Description:Mutant BRAF WM266.4 Cells.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM313753(US10167282, Compound TBAP-04)
Affinity DataIC50:  47nMAssay Description:V600EBRAF was generated by infection of SF9 insect cells cultured in SF-900 II medium (Invitrogen, Paisley, Scotland) with a baculovirus containing f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322547(2-Methyl-4-[3-(5-phenyl-1H-imidazol-2-yl)chroman-6...)
Affinity DataIC50:  52nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322539(5-[3-(3-phenyl-1,2,4-oxadiazol-5-yl)chroman-6-yl]o...)
Affinity DataIC50:  52nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322538(5-[[3-(4-phenyl-1H-imidazol-2-yl)-2H-chromen-6-yl]...)
Affinity DataIC50:  52nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322537(5-[3-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H-imid...)
Affinity DataIC50:  52nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322527(5-[3-(4-tert-butyl-1H-imidazol-2-yl)chroman-6-yl]o...)
Affinity DataIC50:  52nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322519(5-[3-(7-chloro-1H-benzimidazol-2-yl]chroman-6-yl]o...)
Affinity DataIC50:  52nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM313464(N-(5'-(3-fluorooxetan-3- yl)-6'-methoxy-2- methyl-...)
Affinity DataIC50:  59.3nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM313750(US10167282, Compound TBAP-01)
Affinity DataIC50:  62nMAssay Description:V600EBRAF was generated by infection of SF9 insect cells cultured in SF-900 II medium (Invitrogen, Paisley, Scotland) with a baculovirus containing f...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM313751(US10167282, Compound TBAP-02)
Affinity DataIC50:  99nMAssay Description:V600EBRAF was generated by infection of SF9 insect cells cultured in SF-900 II medium (Invitrogen, Paisley, Scotland) with a baculovirus containing f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM322534(5-[3-[5-(4-methylsulfonylphenyl)-1H-imidazol-2-yl]...)
Affinity DataIC50: >100nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM313752(US10167282, Compound TBAP-03)
Affinity DataIC50:  130nMAssay Description:V600EBRAF was generated by infection of SF9 insect cells cultured in SF-900 II medium (Invitrogen, Paisley, Scotland) with a baculovirus containing f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM313484(2-(1,1-difluoroethyl)-N- (3-(5-(3- (fluoromethyl)o...)
Affinity DataIC50:  293nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM313400(N-(3-(6-ethoxy-5-(3- methyloxetan-3- yl)pyridin-3-...)
Affinity DataIC50:  304nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM313486(N-(3-(5-(3- (fluoromethyl)oxetan-3- yl)-6-methoxyp...)
Affinity DataIC50:  323nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM313754(US10167282, Compound TBAP-05)
Affinity DataIC50:  390nMAssay Description:V600EBRAF was generated by infection of SF9 insect cells cultured in SF-900 II medium (Invitrogen, Paisley, Scotland) with a baculovirus containing f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM313485(N-(3-(5-(3- (fluoromethyl)oxetan-3- yl)-6-methoxyp...)
Affinity DataIC50:  417nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM313307(2-(2-cyanopropan-2-yl)- N-(3-(6-ethoxy-5-(3- (fluo...)
Affinity DataIC50:  446nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM313754(US10167282, Compound TBAP-05)
Affinity DataIC50:  450nMAssay Description:Mutant BRAF WM266.4 Cells.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM313333(N-(5'-(3- (fluoromethyl)oxetan-3- yl)-6'-methoxy-2...)
Affinity DataIC50:  469nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM313487(2-(2-cyanopropan-2-yl)- N-(3-(5-(3- (fluoromethyl)...)
Affinity DataIC50:  580nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM189798(US9670203, Compound 1.51)
Affinity DataIC50:  590nMT: 2°CAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM188175(US9670203, Compound 1.35)
Affinity DataIC50:  590nMT: 2°CAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM313396(N-(6'-ethoxy-2-methyl- 5'-(3-methyloxetan-3- yl)-[...)
Affinity DataIC50:  613nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Redx Pharma

US Patent
LigandPNGBDBM186830(US9670203, Compound 1.22 | US9670203, Compound 1.5...)
Affinity DataIC50:  710nMT: 2°CAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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