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Found 31 Enz. Inhib. hit(s) with Target = 'Uridine 5'-monophosphate synthase'
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50459997(47599 | CHEBI:90284 | Pirazofurin | Pyrazofurin)
Affinity DataKi:  17nMAssay Description:Inhibition of human ODCaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50378784(CHEMBL1164953)
Affinity DataKi:  17nM ΔG°:  -44.3kJ/moleT: 2°CAssay Description:Inhibition of human uridine 5'-monophosphate synthase after overnight incubation at room temperature by UV spectroscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM214779(OPRT inhibitor, 2)
Affinity DataKi:  41nM ΔG°:  -42.2kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition constants (Ki, equivalent to Kd for competitive inhibitors) were measured at 25 °C by adding purified OPRT enzymes (25 nM for PfOPRT a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM214786(OPRT inhibitor, 9)
Affinity DataKi:  80nM ΔG°:  -40.5kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition constants (Ki, equivalent to Kd for competitive inhibitors) were measured at 25 °C by adding purified OPRT enzymes (25 nM for PfOPRT a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM214791(OPRT inhibitor, 14)
Affinity DataKi:  83nM ΔG°:  -40.4kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition constants (Ki, equivalent to Kd for competitive inhibitors) were measured at 25 °C by adding purified OPRT enzymes (25 nM for PfOPRT a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM214785(OPRT inhibitor, 8)
Affinity DataKi:  90nM ΔG°:  -40.2kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition constants (Ki, equivalent to Kd for competitive inhibitors) were measured at 25 °C by adding purified OPRT enzymes (25 nM for PfOPRT a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM214784(OPRT inhibitor, 7)
Affinity DataKi:  110nM ΔG°:  -39.7kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition constants (Ki, equivalent to Kd for competitive inhibitors) were measured at 25 °C by adding purified OPRT enzymes (25 nM for PfOPRT a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM214778(OPRT inhibitor, 1 )
Affinity DataKi:  120nM ΔG°:  -39.5kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition constants (Ki, equivalent to Kd for competitive inhibitors) were measured at 25 °C by adding purified OPRT enzymes (25 nM for PfOPRT a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM214797(OPRT inhibitor, 20)
Affinity DataKi:  120nM ΔG°:  -39.5kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition constants (Ki, equivalent to Kd for competitive inhibitors) were measured at 25 °C by adding purified OPRT enzymes (25 nM for PfOPRT a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM214783(OPRT inhibitor, 6)
Affinity DataKi:  140nM ΔG°:  -39.1kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition constants (Ki, equivalent to Kd for competitive inhibitors) were measured at 25 °C by adding purified OPRT enzymes (25 nM for PfOPRT a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM214796(OPRT inhibitor, 19)
Affinity DataKi:  150nM ΔG°:  -38.9kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition constants (Ki, equivalent to Kd for competitive inhibitors) were measured at 25 °C by adding purified OPRT enzymes (25 nM for PfOPRT a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM214794(OPRT inhibitor, 17)
Affinity DataKi:  200nM ΔG°:  -38.2kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition constants (Ki, equivalent to Kd for competitive inhibitors) were measured at 25 °C by adding purified OPRT enzymes (25 nM for PfOPRT a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM214781(OPRT inhibitor, 4)
Affinity DataKi:  200nM ΔG°:  -38.2kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition constants (Ki, equivalent to Kd for competitive inhibitors) were measured at 25 °C by adding purified OPRT enzymes (25 nM for PfOPRT a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM214795(OPRT inhibitor, 18)
Affinity DataKi:  230nM ΔG°:  -37.9kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition constants (Ki, equivalent to Kd for competitive inhibitors) were measured at 25 °C by adding purified OPRT enzymes (25 nM for PfOPRT a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM214793(OPRT inhibitor, 16)
Affinity DataKi:  230nM ΔG°:  -37.9kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition constants (Ki, equivalent to Kd for competitive inhibitors) were measured at 25 °C by adding purified OPRT enzymes (25 nM for PfOPRT a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM214792(OPRT inhibitor, 15)
Affinity DataKi:  240nM ΔG°:  -37.8kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition constants (Ki, equivalent to Kd for competitive inhibitors) were measured at 25 °C by adding purified OPRT enzymes (25 nM for PfOPRT a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM214790(OPRT inhibitor, 13)
Affinity DataKi:  250nM ΔG°:  -37.7kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition constants (Ki, equivalent to Kd for competitive inhibitors) were measured at 25 °C by adding purified OPRT enzymes (25 nM for PfOPRT a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM214787(OPRT inhibitor, 10)
Affinity DataKi:  290nM ΔG°:  -37.3kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition constants (Ki, equivalent to Kd for competitive inhibitors) were measured at 25 °C by adding purified OPRT enzymes (25 nM for PfOPRT a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM27946(uridine derivative, 43 | {[(2R,3S,4R,5R)-5-(6-ethy...)
Affinity DataKi:  350nM ΔG°:  -38.3kJ/molepH: 7.5 T: 2°CAssay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM214782(OPRT inhibitor, 5)
Affinity DataKi:  360nM ΔG°:  -36.8kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition constants (Ki, equivalent to Kd for competitive inhibitors) were measured at 25 °C by adding purified OPRT enzymes (25 nM for PfOPRT a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM214788(OPRT inhibitor, 11)
Affinity DataKi:  520nM ΔG°:  -35.9kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition constants (Ki, equivalent to Kd for competitive inhibitors) were measured at 25 °C by adding purified OPRT enzymes (25 nM for PfOPRT a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM214780(OPRT inhibitor, 3)
Affinity DataKi:  530nM ΔG°:  -35.8kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition constants (Ki, equivalent to Kd for competitive inhibitors) were measured at 25 °C by adding purified OPRT enzymes (25 nM for PfOPRT a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM214789(OPRT inhibitor, 12)
Affinity DataKi:  4.30E+3nM ΔG°:  -30.6kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition constants (Ki, equivalent to Kd for competitive inhibitors) were measured at 25 °C by adding purified OPRT enzymes (25 nM for PfOPRT a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM27945(uridine derivative, 42 | {[(2R,3S,4R,5R)-5-(6-amin...)
Affinity DataKi:  1.66E+4nM ΔG°:  -28.4kJ/molepH: 7.5 T: 2°CAssay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50398698(CHEMBL2178721)
Affinity DataKi:  2.83E+4nMAssay Description:Inhibition of human ODCase by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM27943(uridine derivative, 39 | {[(2R,3S,4R,5R)-5-(5-fluo...)
Affinity DataKi:  9.80E+4nM ΔG°:  -23.8kJ/molepH: 7.5 T: 2°CAssay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50398699(CHEMBL214393)
Affinity DataKi:  2.20E+5nMAssay Description:Inhibition of human ODCase by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50341907(CHEMBL1765122 | ammonium 5-Cyano-2'-deoxy-2'-fluor...)
Affinity DataKi:  7.59E+5nMAssay Description:Inhibition of human 5'-monophosphate decarboxylase by VP-ITC microcalorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50310540(((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)...)
Affinity DataKi:  1.40E+6nMAssay Description:Inhibition of human ODCase by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50341905(CHEMBL1765124 | ammonium 6-Cyano-2'-deoxy-2'-fluor...)
Affinity DataKi: >2.00E+6nMAssay Description:Inhibition of human 5'-monophosphate decarboxylase by VP-ITC microcalorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50341906(Ammonium 6-Amido-2'-deoxy-2'-fluoro-beta-D-uridine...)
Affinity DataKi: >4.00E+6nMAssay Description:Inhibition of human 5'-monophosphate decarboxylase by VP-ITC microcalorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed