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Found 433 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein phosphatase'
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
Nagoya University

Curated by ChEMBL
LigandPNGBDBM50375611(CHEMBL408120)
Affinity DataKi:  3.40nMAssay Description:Inhibition of PP1gamma by firefly bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
Nagoya University

Curated by ChEMBL
LigandPNGBDBM50375608(CHEMBL406220)
Affinity DataKi:  4.5nMAssay Description:Inhibition of PP1gamma by firefly bioluminescence assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
Nagoya University

Curated by ChEMBL
LigandPNGBDBM50375616(CHEMBL405248)
Affinity DataKi:  8nMAssay Description:Inhibition of PP1gamma by firefly bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
Nagoya University

Curated by ChEMBL
LigandPNGBDBM50375613(CHEMBL261577)
Affinity DataKi:  8.40nMAssay Description:Inhibition of PP1gamma by firefly bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
Nagoya University

Curated by ChEMBL
LigandPNGBDBM50375612(CHEMBL427915)
Affinity DataKi:  17.3nMAssay Description:Inhibition of PP1gamma by firefly bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
Nagoya University

Curated by ChEMBL
LigandPNGBDBM50375609(CHEMBL406283)
Affinity DataKi:  19.6nMAssay Description:Inhibition of PP1gamma by firefly bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
Nagoya University

Curated by ChEMBL
LigandPNGBDBM50375614(CHEMBL259235)
Affinity DataKi:  21.3nMAssay Description:Inhibition of PP1gamma by firefly bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
Nagoya University

Curated by ChEMBL
LigandPNGBDBM50375610(CHEMBL436904)
Affinity DataKi:  23.9nMAssay Description:Inhibition of PP1gamma by firefly bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
Nagoya University

Curated by ChEMBL
LigandPNGBDBM50375617(CHEMBL261094)
Affinity DataKi:  32.5nMAssay Description:Inhibition of PP1gamma by firefly bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
Nagoya University

Curated by ChEMBL
LigandPNGBDBM50375615(CHEMBL261583)
Affinity DataKi:  49.7nMAssay Description:Inhibition of PP1gamma by firefly bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A activator(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM199180(US9217012, 10)
Affinity DataKi: >1.00E+3nM ΔG°: >-34.2kJ/molepH: 7.0 T: 2°CAssay Description:PTP activity was assayed using p-nitrophenyl phosphate (pNPP) as a substrate in DMG buffer (50 mM DMG, pH 7.0, 1 mM EDTA, 150 mM NaCl, 2 mM DTT, 0.1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein phosphatase PP1-alpha catalytic subunit(Homo sapiens (Human))
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126635(3-[3-({[(Z)-amino(imino)methyl]amino}oxy)ethoxy]-5...)
Affinity DataKi: >6.70E+4nMAssay Description:In vitro inhibitory activity of the compound was tested against serine protease UrokinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase(Enterobacteria phage lambda)
Utah State University

Curated by ChEMBL
LigandPNGBDBM50131868(7-Phosphonomethyl-naphthalene-1-carboxylic acid | ...)
Affinity DataKi:  1.30E+5nMAssay Description:Inhibitory activity against Serine/Threonine Protein Phosphatase (Lamda protein phosphatase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase(Enterobacteria phage lambda)
Utah State University

Curated by ChEMBL
LigandPNGBDBM50131866(7-Thiophosphonomethyl-naphthalene-1-carboxylic aci...)
Affinity DataKi:  1.70E+5nMAssay Description:Inhibitory activity against Serine/Threonine Protein Phosphatase (Lamda protein phosphatase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase(Enterobacteria phage lambda)
Utah State University

Curated by ChEMBL
LigandPNGBDBM50131860(6-Phosphono-hexanoic acid | CHEMBL122539)
Affinity DataKi:  4.30E+5nMAssay Description:Inhibitory activity against Serine/Threonine Protein Phosphatase (Lamda protein phosphatase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase(Enterobacteria phage lambda)
Utah State University

Curated by ChEMBL
LigandPNGBDBM50131863(CHEMBL331460 | Phenylsulfanylmethyl-phosphonothioi...)
Affinity DataKi:  4.70E+5nMAssay Description:Inhibitory activity against Serine/Threonine Protein Phosphatase (Lamda protein phosphatase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase(Enterobacteria phage lambda)
Utah State University

Curated by ChEMBL
LigandPNGBDBM50131861(Benzyl-phosphonothioic acid | CHEMBL123163)
Affinity DataKi:  5.70E+5nMAssay Description:Inhibitory activity against Serine/Threonine Protein Phosphatase (Lamda protein phosphatase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase(Enterobacteria phage lambda)
Utah State University

Curated by ChEMBL
LigandPNGBDBM50131862(CHEMBL122938 | methylphosphonic acid)
Affinity DataKi:  1.01E+6nMAssay Description:Inhibitory activity against Serine/Threonine Protein Phosphatase (Lamda protein phosphatase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase(Enterobacteria phage lambda)
Utah State University

Curated by ChEMBL
LigandPNGBDBM50131865(6-Thiophosphono-hexanoic acid methyl ester | CHEMB...)
Affinity DataKi:  1.10E+6nMAssay Description:Inhibitory activity against Serine/Threonine Protein Phosphatase (Lamda protein phosphatase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase(Enterobacteria phage lambda)
Utah State University

Curated by ChEMBL
LigandPNGBDBM50131871(CHEMBL122097 | Methylsulfanylmethyl-phosphonothioi...)
Affinity DataKi:  1.20E+6nMAssay Description:Inhibitory activity against Serine/Threonine Protein Phosphatase (Lamda protein phosphatase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase(Enterobacteria phage lambda)
Utah State University

Curated by ChEMBL
LigandPNGBDBM50131867(6-Thiophosphono-hexanoic acid | CHEMBL123990)
Affinity DataKi:  1.50E+6nMAssay Description:Inhibitory activity against Serine/Threonine Protein Phosphatase (Lamda protein phosphatase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase(Enterobacteria phage lambda)
Utah State University

Curated by ChEMBL
LigandPNGBDBM50131869(CHEMBL122577 | Methyl-phosphonothioic acid)
Affinity DataKi:  1.70E+7nMAssay Description:Inhibitory activity against Serine/Threonine Protein Phosphatase (Lamda protein phosphatase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase(Enterobacteria phage lambda)
Utah State University

Curated by ChEMBL
LigandPNGBDBM50131870(Butyl-phosphonothioic acid | CHEMBL331046)
Affinity DataKi:  2.00E+7nMAssay Description:Inhibitory activity against Serine/Threonine Protein Phosphatase (Lamda protein phosphatase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
Nagoya University

Curated by ChEMBL
LigandPNGBDBM50061067(15-(3-Guanidino-propyl)-8-isobutyl-18-((1E,3E)-6-m...)
Affinity DataIC50:  0.0100nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in E275RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
Nagoya University

Curated by ChEMBL
LigandPNGBDBM50061067(15-(3-Guanidino-propyl)-8-isobutyl-18-((1E,3E)-6-m...)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in wild typeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
Nagoya University

Curated by ChEMBL
LigandPNGBDBM50061067(15-(3-Guanidino-propyl)-8-isobutyl-18-((1E,3E)-6-m...)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in D220VMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Gallus gallus)
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50110686(14-Ethylidene-2-isopropyl-5-(6-methoxy-3,5-dimethy...)
Affinity DataIC50:  0.0300nMAssay Description:Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50061067(15-(3-Guanidino-propyl)-8-isobutyl-18-((1E,3E)-6-m...)
Affinity DataIC50:  0.0650nMAssay Description:Observed inhibition activity of the compounds against protein phosphatases 2A (PP2A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50110676(CHEMBL280487 | okadaic acid)
Affinity DataIC50:  0.0700nMAssay Description:Tested for inhibition of purified catalytic subunit of protein phosphatase-2A from human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Gallus gallus)
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50061067(15-(3-Guanidino-propyl)-8-isobutyl-18-((1E,3E)-6-m...)
Affinity DataIC50:  0.100nMAssay Description:Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50061067(15-(3-Guanidino-propyl)-8-isobutyl-18-((1E,3E)-6-m...)
Affinity DataIC50:  0.100nMAssay Description:Tested for inhibition of purified catalytic subunit of protein phosphatase-2A from human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50110681(CHEMBL430266 | Calyculin-A)
Affinity DataIC50:  0.130nMAssay Description:Tested for inhibition of purified catalytic subunit of protein phosphatase-2A from human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
Nagoya University

Curated by ChEMBL
LigandPNGBDBM50110681(CHEMBL430266 | Calyculin-A)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in D220VMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Gallus gallus)
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50061066((5R,6S,9S,12S,13S,16R)-2-Eth-(Z)-ylidene-9-(3-guan...)
Affinity DataIC50:  0.200nMAssay Description:Observed inhibition activity against protein phosphatase 2A (PP2A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Gallus gallus)
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50110681(CHEMBL430266 | Calyculin-A)
Affinity DataIC50:  0.200nMAssay Description:Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Gallus gallus)
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50110685(25-Isobutyl-15-(6-methoxy-3,5-dimethyl-7-phenyl-he...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of microcystin analogues to catalytic subunits of Serine/threonine protein phosphatase 2A (PP2Ac)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform(Bos taurus)
University Of California Irvine

Curated by ChEMBL
LigandPNGBDBM50135699((10S,13S,18S,19S,22R)-8-Isobutyl-18-((1E,3E)-(5S,6...)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory concentration of the compound against protein phosphatase 1 (PP1) using phosphorylase-a assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
Nagoya University

Curated by ChEMBL
LigandPNGBDBM50110681(CHEMBL430266 | Calyculin-A)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in E275RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Gallus gallus)
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50110676(CHEMBL280487 | okadaic acid)
Affinity DataIC50:  0.450nMAssay Description:Observed inhibition activity against protein phosphatase 2A (PP2A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
Nagoya University

Curated by ChEMBL
LigandPNGBDBM50110681(CHEMBL430266 | Calyculin-A)
Affinity DataIC50:  0.450nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in wild typeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
Nagoya University

Curated by ChEMBL
LigandPNGBDBM50061067(15-(3-Guanidino-propyl)-8-isobutyl-18-((1E,3E)-6-m...)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in C127SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Gallus gallus)
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50366883(TAUTOMYCIN)
Affinity DataIC50:  0.700nMAssay Description:Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
Nagoya University

Curated by ChEMBL
LigandPNGBDBM50061067(15-(3-Guanidino-propyl)-8-isobutyl-18-((1E,3E)-6-m...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in Y272FMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Gallus gallus)
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50110676(CHEMBL280487 | okadaic acid)
Affinity DataIC50:  1nMAssay Description:Inhibition activity against protein phosphatase 2A (PP2A), activity taken from literatureMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A activator(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM40776(Calyculin A (4) | Calyculin B (19) | Calyculin E (...)
Affinity DataIC50:  1nMAssay Description:Protein phosphatase inhibitory activity of calyculin derivatives.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Gallus gallus)
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50110676(CHEMBL280487 | okadaic acid)
Affinity DataIC50:  1nMAssay Description:Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Gallus gallus)
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50110676(CHEMBL280487 | okadaic acid)
Affinity DataIC50:  1nMAssay Description:Concentration required to inhibit the action of protein phosphatase 2AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A activator(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM40787(Des-N-methylcalyculin A (20))
Affinity DataIC50:  1nMAssay Description:Protein phosphatase inhibitory activity of calyculin derivatives.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A activator(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM40777(Hemicalyculin A (5))
Affinity DataIC50:  1nMAssay Description:Protein phosphatase inhibitory activity of calyculin derivatives.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Gallus gallus)
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50061066((5R,6S,9S,12S,13S,16R)-2-Eth-(Z)-ylidene-9-(3-guan...)
Affinity DataIC50:  1nMAssay Description:Inhibition activity against protein phosphatase 2A (PP2A), activity taken from literatureMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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