KEGG   Homo sapiens (human): 290
Entry
290               CDS       T01001                                 
Symbol
ANPEP, AP-M, AP-N, APN, CD13, GP150, LAP1, P150, PEPN, hAPN
Name
(RefSeq) alanyl aminopeptidase, membrane
  KO
K11140  aminopeptidase N [EC:3.4.11.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa01100  Metabolic pathways
hsa04614  Renin-angiotensin system
hsa04640  Hematopoietic cell lineage
Drug target
Tosedostat: D10026
Ubenimex: D00087<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    290 (ANPEP)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    290 (ANPEP)
  09152 Endocrine system
   04614 Renin-angiotensin system
    290 (ANPEP)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    290 (ANPEP)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    290 (ANPEP)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    290 (ANPEP)
   04090 CD molecules [BR:hsa04090]
    290 (ANPEP)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.11  Aminopeptidases
    3.4.11.2  membrane alanyl aminopeptidase
     290 (ANPEP)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M1
   290 (ANPEP)
Membrane trafficking [BR:hsa04131]
 Endoplasmic reticulum (ER) - Golgi transport
  Forward pathways
   ER-Golgi intermediate compartment (ERGIC) proteins
    290 (ANPEP)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of microglial cells
   290 (ANPEP)
CD molecules [BR:hsa04090]
 Proteins
  290 (ANPEP)
SSDB
Motif
Pfam: ERAP1_C Peptidase_M1 Peptidase_M1_N DUF5700 Aminopep BSP
Other DBs
NCBI-GeneID: 290
NCBI-ProteinID: NP_001141
OMIM: 151530
HGNC: 500
Ensembl: ENSG00000166825
UniProt: P15144 Q59E93
Structure
Position
15:complement(89784895..89814852)
AA seq 967 aa
MAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNPA
SATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVI
IIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDS
EFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHP
KDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLI
RIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLV
TYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYL
GADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKG
ASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIM
NRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDY
WLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQ
IINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKN
YLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWM
ENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWI
LNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSN
LIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQ
WFTENSK
NT seq 2904 nt   +upstreamnt  +downstreamnt
atggccaagggcttctatatttccaagtccctgggcatcctggggatcctcctgggcgtg
gcagccgtgtgcacaatcatcgcactgtcagtggtgtactcccaggagaagaacaagaac
gccaacagctcccccgtggcctccaccaccccgtccgcctcagccaccaccaaccccgcc
tcggccaccaccttggaccaaagtaaagcgtggaatcgttaccgcctccccaacacgctg
aaacccgattcctaccgggtgacgctgagaccgtacctcacccccaatgacaggggcctg
tacgtttttaagggctccagcaccgtccgtttcacctgcaaggaggccactgacgtcatc
atcatccacagcaagaagctcaactacaccctcagccaggggcacagggtggtcctgcgt
ggtgtgggaggctcccagccccccgacattgacaagactgagctggtggagcccaccgag
tacctggtggtgcacctcaagggctccctggtgaaggacagccagtatgagatggacagc
gagttcgagggggagttggcagatgacctggcgggcttctaccgcagcgagtacatggag
ggcaatgtcagaaaggtggtggccactacacagatgcaggctgcagatgcccggaagtcc
ttcccatgcttcgatgagccggccatgaaggccgagttcaacatcacgcttatccacccc
aaggacctgacagccctgtccaacatgcttcccaaaggtcccagcaccccacttccagaa
gaccccaactggaatgtcactgagttccacaccacgcccaagatgtccacgtacttgctg
gccttcattgtcagtgagttcgactacgtggagaagcaggcatccaatggtgtcttgatc
cggatctgggcccggcccagtgccattgcggcgggccacggcgattatgccctgaacgtg
acgggccccatccttaacttctttgctggtcattatgacacaccctacccactcccaaaa
tcagaccagattggcctgccagacttcaacgccggcgccatggagaactggggactggtg
acctaccgggagaactccctgctgttcgaccccctgtcctcctccagcagcaacaaggag
cgggtggtcactgtgattgctcatgagctggcccaccagtggttcgggaacctggtgacc
atagagtggtggaatgacctgtggctgaacgagggcttcgcctcctacgtggagtacctg
ggtgctgactatgcggagcccacctggaacttgaaagacctcatggtgctgaatgatgtg
taccgcgtgatggcagtggatgcactggcctcctcccacccgctgtccacacccgcctcg
gagatcaacacgccggcccagatcagtgagctgtttgacgccatctcctacagcaagggc
gcctcagtcctcaggatgctctccagcttcctgtccgaggacgtattcaagcagggcctg
gcgtcctacctccacacctttgcctaccagaacaccatctacctgaacctgtgggaccac
ctgcaggaggctgtgaacaaccggtccatccaactccccaccaccgtgcgggacatcatg
aaccgctggaccctgcagatgggcttcccggtcatcacggtggataccagcacggggacc
ctttcccaggagcacttcctccttgaccccgattccaatgttacccgcccctcagaattc
aactacgtgtggattgtgcccatcacatccatcagagatggcagacagcagcaggactac
tggctgatagatgtaagagcccagaacgatctcttcagcacatcaggcaatgagtgggtc
ctgctgaacctcaatgtgacgggctattaccgggtgaactacgacgaagagaactggagg
aagattcagactcagctgcagagagaccactcggccatccctgtcatcaatcgggcacag
atcattaatgacgccttcaacctggccagtgcccataaggtccctgtcactctggcgctg
aacaacaccctcttcctgattgaagagagacagtacatgccctgggaggccgccctgagc
agcctgagctacttcaagctcatgtttgaccgctccgaggtctatggccccatgaagaac
tacctgaagaagcaggtcacacccctcttcattcacttcagaaataataccaacaactgg
agggagatcccagaaaacctgatggaccagtacagcgaggttaatgccatcagcaccgcc
tgctccaacggagttccagagtgtgaggagatggtctctggccttttcaagcagtggatg
gagaaccccaataataacccgatccaccccaacctgcggtccaccgtctactgcaacgct
atcgcccagggcggggaggaggagtgggacttcgcctgggagcagttccgaaatgccaca
ctggtcaatgaggctgacaagctccgggcagccctggcctgcagcaaagagttgtggatc
ctgaacaggtacctgagctacaccctgaacccggacttaatccggaagcaggacgccacc
tctaccatcatcagcattaccaacaacgtcattgggcaaggtctggtctgggactttgtc
cagagcaactggaagaagctttttaacgattatggtggtggctcgttctccttctccaac
ctcatccaggcagtgacacgacgattctccaccgagtatgagctgcagcagctggagcag
ttcaagaaggacaacgaggaaacaggcttcggctcaggcacccgggccctggagcaagcc
ctggagaagacgaaagccaacatcaagtgggtgaaggagaacaaggaggtggtgctccag
tggttcacagaaaacagcaaatag

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Ontology (6)   
   KEGG BRITE (6)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (1)   
   OMIM (1)   
Drug (2)   
   KEGG DRUG (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (38)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (17)   
   OC (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (21)   
   RefSeq(nuc) (3)   
   GenBank (9)   
   EMBL (9)   
3D Structure (12)   
   PDB (12)   
Protein domain (6)   
   Pfam (6)   
All databases (106)   

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