KEGG   Homo sapiens (human): 51776
Entry
51776             CDS       T01001                                 
Symbol
MAP3K20, AZK, CNM6, MLK7, MLT, MLTK, MLTKalpha, MLTKbeta, MRK, SFMMP, ZAK, mlklak, pk
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 20
  KO
K04424  sterile alpha motif and leucine zipper containing kinase AZK [EC:2.7.11.25]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
Network
nt06526  MAPK signaling
  Element
N01594  MLK-JNK signaling pathway
Disease
H00471  Split-hand/foot malformation
H00700  Centronuclear myopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    51776 (MAP3K20)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    51776 (MAP3K20)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     51776 (MAP3K20)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  MLK family
   51776 (MAP3K20)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SAM_1 SAM_2 SAM_PNT ABC1 SAM_Ste50p SAM_4
Other DBs
NCBI-GeneID: 51776
NCBI-ProteinID: NP_057737
OMIM: 609479
HGNC: 17797
Ensembl: ENSG00000091436
UniProt: Q9NYL2
Structure
Position
2:173075517..173268015
AA seq 800 aa
MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL
SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY
LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS
LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH
QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD
LSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAE
MSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPL
IKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNT
NLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQ
DEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSP
FFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFS
SGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQS
ALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRP
SPAKTNKERARGDHRGWRNF
NT seq 2403 nt   +upstreamnt  +downstreamnt
atgtcgtctctcggtgcctcctttgtgcaaattaaatttgatgacttgcagttttttgaa
aactgcggtggaggaagttttgggagtgtttatcgagccaaatggatatcacaggacaag
gaggtggctgtaaagaagctcctcaaaatagagaaagaggcagaaatactcagtgtcctc
agtcacagaaacatcatccagttttatggagtaattcttgaacctcccaactatggcatt
gtcacagaatatgcttctctgggatcactctatgattacattaacagtaacagaagtgag
gagatggatatggatcacattatgacctgggccactgatgtagccaaaggaatgcattat
ttacatatggaggctcctgtcaaggtgattcacagagacctcaagtcaagaaacgttgtt
atagctgctgatggagtattgaagatctgtgactttggtgcctctcggttccataaccat
acaacacacatgtccttggttggaactttcccatggatggctccagaagttatccagagt
ctccctgtgtcagaaacttgtgacacatattcctatggtgtggttctctgggagatgcta
acaagggaggtcccctttaaaggtttggaaggattacaagtagcttggcttgtagtggaa
aaaaacgagagattaaccattccaagcagttgccccagaagttttgctgaactgttacat
cagtgttgggaagctgatgccaagaaacggccatcattcaagcaaatcatttcaatcctg
gagtccatgtcaaatgacacgagccttcctgacaagtgtaactcattcctacacaacaag
gcggagtggaggtgcgaaattgaggcaactcttgagaggctaaagaaactagagcgtgat
ctcagctttaaggagcaggagcttaaagaacgagaaagacgtttaaagatgtgggagcaa
aagctgacagagcagtccaacaccccgctgctgccttcctttgagattggtgcatggacg
gaagacgatgtgtattgttgggttcagcagctcgtcagaaaaggtgactcttcagcagag
atgagtgtatatgcaagcttgtttaaagaaaacaacattacagggaagcggctgctgctg
ctggaggaagaagacctgaaagacatgggcattgtctccaaggggcatatcattcacttc
aagtcagccattgagaaattaacccatgattacataaatttgtttcacttcccaccacta
attaaggactcaggaggtgaacctgaagaaaatgaggaaaaaatagtgaacctggaactg
gtttttggttttcacttgaaaccaggaactggcccacaggattgtaagtggaaaatgtat
atggagatggatggggatgaaattgcaataacctacataaaagatgtgacattcaacact
aacctacctgatgcggagattttaaagatgacaaagccaccatttgtaatggagaagtgg
attgtaggaatagcaaaaagtcagactgtggagtgcactgtcacatatgagagtgatgtt
agaactccaaaaagcactaaacatgtccattcgattcagtggagtagaacaaaacctcag
gatgaagtgaaagcagtccaacttgccattcagacattattcaccaattcagatggcaac
cctggaagcaggtccgactcaagtgctgattgccagtggttagatactctgaggatgcgg
cagattgcatccaacacttctttacagcgttcccagagcaatcctattctggggtcaccg
ttcttctcacactttgatggccaggattcctacgctgctgctgtgagacggccccaggtg
cccattaagtatcaacagattacacctgtgaaccagtccagaagctcgtctcctactcag
tatggactgaccaaaaacttctcttccctacatctcaactctagggacagtggcttttcc
agtggcaatactgacacctcttcagagaggggtcgatactcagacagaagcaggaacaaa
tatggacgtggtagtatatcactcaattcttctcctagaggaagatacagtggaaagagt
cagcattccactccttcaagaggaagataccctggaaagttctacagggtttctcagtca
gcactcaatcctcaccagtcgcctgacttcaagagaagccccagggacctccaccaaccc
aacaccataccagggatgcctttgcaccctgagactgactcaagagccagtgaagaggac
agcaaagtcagcgaagggggctggacaaaagtggaataccggaaaaagccccacaggcca
tctcccgccaaaaccaataaagagagagccagaggggaccaccgtggatggagaaacttt
tga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG ORTHOLOGY (1)   
   RefGene (18)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (16)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (14)   
DNA sequence (60)   
   RefSeq(nuc) (14)   
   GenBank (23)   
   EMBL (23)   
3D Structure (6)   
   PDB (6)   
Protein domain (8)   
   Pfam (8)   
All databases (129)   

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