2H96: Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun NH2-terminal Kinase Inhibitors

PDB ID: 2H96Download
MMDB ID: 40539
PDB Deposition Date: 2006/6/9
Updated in MMDB: 2006/12
Experimental Method:
x-ray diffraction
Resolution: 3  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 2H96: dimeric; determined by author and by software (PISA)
Molecular Components in 2H96
Label Count Molecule
Proteins (2 molecules)
1
Mitogen-activated Protein Kinase 8
Molecule annotation
1
C-jun-amino-terminal Kinase-interacting Protein 1
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
3
SULFATE IONSULFATE ION
2
2
5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE
3
2
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303