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4ER6:
Crystal structure of human DOT1L in complex with inhibitor SGC0946
PDB ID:
4ER6
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MMDB ID:
99761
PDB Deposition Date:
2012/4/19
Updated in MMDB:
2017/11
Experimental Method:
x-ray diffraction
Resolution:
2.3 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 4ER6: monomeric; determined by software (PISA)
Molecular Components in 4ER6
Label
Count
Molecule
Protein (1 molecule)
A
1
Histone-lysine N-methyltransferase, H3 Lysine-79 Specific
(Gene symbol:
DOT1L
)
Chemicals and Non-standard biopolymers (3 molecules)
1
1
BROMIDE ION
2
1
5-bromo-7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine
3
1
SODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303