3HR1: Discovery of novel inhibitors of PDE10A

PDB ID: 3HR1Download
MMDB ID: 75814
PDB Deposition Date: 2009/6/8
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 1.53  Å
Source Organism:
Similar Structures:
Biological Unit for 3HR1: monomeric; determined by author
Molecular Components in 3HR1
Label Count Molecule
Protein (1 molecule)
1
Camp and Camp-inhibited Cgmp 3',5'-cyclic Phosphodiesterase 10A
(Gene symbol: Pde10a)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
2
SULFATE IONSULFATE ION
2
1
2-{[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy]methyl}quinoline2-{[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy]methyl}quinoline
3
1
ZINC IONZINC ION
4
1
MAGNESIUM IONMAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303