4CFF: Structure of full length human AMPK in complex with a small molecule activator, a thienopyridone derivative (A-769662)

PDB ID: 4CFFDownload
MMDB ID: 175284
PDB Deposition Date: 2013/11/14
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 3.924  Å
Source Organism:
Similar Structures:
Biological Unit for 4CFF: trimeric; determined by author and by software (PISA)
Molecular Components in 4CFF
Label Count Molecule
Proteins (3 molecules)
1
5'-amp-activated Protein Kinase Catalytic Subunit Alpha-2
(Gene symbol: PRKAA2)
Molecule annotation
1
5'-amp-activated Protein Kinase Subunit Beta-1
(Gene symbol: PRKAB1)
Molecule annotation
1
5'-amp-activated Protein Kinase Subunit Gamma-1
(Gene symbol: PRKAG1)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
STAUROSPORINESTAUROSPORINE
2
1
3-[4-(2-hydroxyphenyl)phenyl]-4-oxidanyl-6-oxidanylidene-7H-thieno[2,3-b]pyridine-5-carbonitrile3-[4-(2-hydroxyphenyl)phenyl]-4-oxidanyl-6-oxidanylidene-7H-thieno[2,3-b]pyridine-5-carbonitrile
3
2
ADENOSINE MONOPHOSPHATEADENOSINE MONOPHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303