4EWS: Crystal structure of cholesteryl ester transfer protein in complex with inhibitors

PDB ID: 4EWSDownload
MMDB ID: 102716
PDB Deposition Date: 2012/4/27
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 2.59  Å
Source Organism:
Similar Structures:
Biological Unit for 4EWS: monomeric; determined by author and by software (PISA)
Molecular Components in 4EWS
Label Count Molecule
Protein (1 molecule)
1
Cetp
(Gene symbol: CETP)
Molecule annotation
Chemicals and Non-standard biopolymers (11 molecules)
1
2
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
1
alpha-D-mannopyranosealpha-D-mannopyranose
3
1
alpha-L-fucopyranosealpha-L-fucopyranose
4
2
CHOLESTERYL OLEATECHOLESTERYL OLEATE
5
1
1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
6
2
TRIETHYLENE GLYCOLTRIETHYLENE GLYCOL
7
1
CHLORIDE IONCHLORIDE ION
8
1
ethyl (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H )-carboxylateethyl (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H )-carboxylate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303