3ARA: Discovery of Novel Uracil Derivatives as Potent Human dUTPase Inhibitors

PDB ID: 3ARADownload
MMDB ID: 87124
PDB Deposition Date: 2010/11/25
Updated in MMDB: 2010/12
Experimental Method:
x-ray diffraction
Resolution: 1.7  Å
Source Organism:
Similar Structures:
Biological Unit for 3ARA: trimeric; determined by author and by software (PISA)
Molecular Components in 3ARA
Label Count Molecule
Proteins (3 molecules)
3
Deoxyuridine 5'-triphosphate Nucleotidohydrolase
(Gene symbol: DUT)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
3
1-[3-({(2R)-2-[hydroxy(diphenyl)methyl]pyrrolidin-1-yl}sulfonyl)propyl]pyrimidine-2,4(1H,3H)-dione1-[3-({(2R)-2-[hydroxy(diphenyl)methyl]pyrrolidin-1-yl}sulfonyl)propyl]pyrimidine-2,4(1H,3H)-dione
2
2
MAGNESIUM IONMAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303