4KFN: Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

PDB ID: 4KFNDownload
MMDB ID: 109989
PDB Deposition Date: 2013/4/27
Updated in MMDB: 2013/07
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 4KFN: dimeric; determined by author and by software (PISA)
Molecular Components in 4KFN
Label Count Molecule
Proteins (2 molecules)
2
Nicotinamide Phosphoribosyltransferase
(Gene symbol: NAMPT)
Molecule annotation
Chemicals and Non-standard biopolymers (18 molecules)
1
2
N-[4-(piperidin-1-ylsulfonyl)benzyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamideN-[4-(piperidin-1-ylsulfonyl)benzyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide
2
6
PHOSPHATE IONPHOSPHATE ION
3
10
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303