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3T3C:
Structure of HIV PR resistant patient derived mutant (comprising 22 mutations) in complex with DRV
PDB ID:
3T3C
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MMDB ID:
100651
PDB Deposition Date:
2011/7/25
Updated in MMDB:
2012/08
Experimental Method:
x-ray diffraction
Resolution:
2.1 Å
Source Organism:
Human immunodeficiency virus type 1 (BRU ISOLATE)
Similar Structures:
VAST+
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Biological Unit for 3T3C: dimeric; determined by author
Molecular Components in 3T3C
Label
Count
Molecule
Proteins (2 molecules)
A
B
2
Hiv-1 Protease
Chemicals and Non-standard biopolymers (5 molecules)
1
1
(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE
2
2
BETA-MERCAPTOETHANOL
3
2
SULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303