Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity

J Med Chem. 1991 Dec;34(12):3399-402. doi: 10.1021/jm00116a010.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alkaloids
  • Animals
  • Brain / enzymology
  • Cholinesterase Inhibitors / chemical synthesis
  • Cholinesterase Inhibitors / chemistry*
  • Cholinesterase Inhibitors / pharmacology
  • In Vitro Techniques
  • Models, Molecular
  • Molecular Conformation
  • Rats
  • Sesquiterpenes / chemical synthesis
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / pharmacology
  • Structure-Activity Relationship

Substances

  • Alkaloids
  • Cholinesterase Inhibitors
  • Sesquiterpenes
  • huperzine A