Solid phase synthesis of diamides as potential bone resorption inhibitors

Bioorg Med Chem Lett. 2000 Mar 6;10(5):503-7. doi: 10.1016/s0960-894x(00)00025-1.

Abstract

Unsymmetrical diamide libraries have been prepared by a general and versatile solid phase route, using diacid templates in combination with aromatic and aliphatic amines chosen with the help of statistical experimental design. The compounds were tested as potential inhibitors of osteoclast vacuolar ATPase.

MeSH terms

  • Adenosine Triphosphatases / antagonists & inhibitors
  • Amides / chemical synthesis*
  • Amides / pharmacology*
  • Animals
  • Bone Resorption / drug therapy*
  • Chickens
  • Databases, Factual
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / pharmacology
  • Osteoclasts / drug effects
  • Osteoclasts / enzymology
  • Templates, Genetic

Substances

  • Amides
  • Enzyme Inhibitors
  • Adenosine Triphosphatases