Abstract
A collection of (2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl derivatives have been tested for their inhibitory activities toward 25 glycosidases. Competitive (K(i)=7.4 microM) and selective inhibition of alpha-mannosidase from jack bean has been found for (2R,3R,4S)-2-[(benzylamino)methyl]pyrrolidine-3,4-diol and other derivatives.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Cattle
-
Drug Design
-
Drug Evaluation, Preclinical
-
Enzyme Inhibitors / chemistry*
-
Enzyme Inhibitors / pharmacology*
-
Inhibitory Concentration 50
-
Mannosidases / antagonists & inhibitors*
-
Structure-Activity Relationship
-
alpha-Mannosidase
Substances
-
Enzyme Inhibitors
-
Mannosidases
-
alpha-Mannosidase