Abstract
Parallel synthesis was used to explore the SAR of a peptidomimetic caspase inhibitor. The most potent compound had nanomolar activity against caspases 1, 3, 6, 7, and 8.
MeSH terms
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Acylation
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Caspase Inhibitors*
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Dipeptides / chemical synthesis*
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Dipeptides / pharmacology*
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology*
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Indicators and Reagents
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Isoenzymes / antagonists & inhibitors
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Oligopeptides / chemical synthesis
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Oligopeptides / pharmacology
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Structure-Activity Relationship
Substances
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Caspase Inhibitors
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Dipeptides
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Enzyme Inhibitors
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Indicators and Reagents
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Isoenzymes
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Oligopeptides