Abstract
A series of novel tetracyclic tetrahydrofuran derivatives was prepared and evaluated for its potential psychotropic properties. In vitro affinities for multiple dopaminergic, serotonergic, alpha-adrenergic, and histamine receptors and for the norepinephrine transporter as well as the ED(50) values obtained in some in vivo assays for antipsychotic, anxiolytic, and antidepressant potential are reported. Compounds (-)-1, (-)-8d, and (+)-8d have been identified as potential broad-spectrum psychotropic agents.
MeSH terms
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Animals
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Anti-Anxiety Agents / chemical synthesis
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Anti-Anxiety Agents / chemistry
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Anti-Anxiety Agents / pharmacology
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Antidepressive Agents / chemical synthesis
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Antidepressive Agents / chemistry
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Antidepressive Agents / pharmacology
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Antipsychotic Agents / chemical synthesis
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Antipsychotic Agents / chemistry
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Antipsychotic Agents / pharmacology
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Furans / chemical synthesis*
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Furans / chemistry
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Furans / pharmacology
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Heterocyclic Compounds, 4 or More Rings / chemical synthesis*
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Heterocyclic Compounds, 4 or More Rings / chemistry
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Heterocyclic Compounds, 4 or More Rings / pharmacology
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Humans
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In Vitro Techniques
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Mice
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Psychotropic Drugs / chemical synthesis*
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Psychotropic Drugs / chemistry
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Psychotropic Drugs / pharmacology
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Radioligand Assay
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Rats
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Anti-Anxiety Agents
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Antidepressive Agents
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Antipsychotic Agents
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Furans
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Heterocyclic Compounds, 4 or More Rings
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Psychotropic Drugs