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Target
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Ki
IC50
Kd
EC50
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ΔH°
-TΔS°
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rcsb
for BCoR-BCL6
1R28
: crystal structure of the b-cell lymphoma 6 (bcl6) btb domain to 2.2 angstrom (
10.1016/S1097-2765(03)00454-4
)
1R29
: crystal structure of the b-cell lymphoma 6 (bcl6) btb domain to 1.3 angstrom (
10.1016/S1097-2765(03)00454-4
)
1R2B
: crystal structure of the bcl6 btb domain complexed with a smrt co-repressor peptide (
10.1016/S1097-2765(03)00454-4
)
2LCE
: chemical shift assignment of hr4436b from homo sapiens, northeast structural genomics consortium
3BIM
: crystal structure of the bcl6 btb domain dimer in complex with the bcor bbd corepressor peptide (
10.1016/J.MOLCEL.2007.12.026
)
3E4U
: crystal structure of the wild-type human bcl6 btb/poz domain (
10.1107/S1744309108036063
)
3LBZ
: crystal structure of the bcl6 btb domain complexed with the small molecule inhibitor 79-6 (
10.1016/J.CCR.2009.12.050
)
4CP3
: the structure of bcl6 btb (poz) domain in complex with the ansamycin antibiotic rifabutin. (
10.1371/JOURNAL.PONE.0090889
)
4U2M
: crystal structure of a complex of the miz1- and bcl6 poz domains. (
10.1107/S2053230X14023449
)
5H7G
: crystal structure of the bcl6 btb domain in complex with f1324 (
10.1016/J.BBRC.2016.11.060
)
5H7H
: crystal structure of the bcl6 btb domain in complex with f1324(10-13) (
10.1016/J.BBRC.2016.11.060
)
5MW2
: crystal structure of bcl-6 btb-domain with bi-3802 (
10.1016/J.CELREP.2017.08.081
)
5MW6
: crystal structure of the bcl6 btb-domain with compound 1 (
10.1016/J.CELREP.2017.08.081
)
5MWD
: crystal structure of the bcl6 btb-domain with compound 2 (
10.1016/J.CELREP.2017.08.081
)
5N1X
: crystal structure of the bcl6 btb domain in complex with pyrazolo- pyrimidine ligand (
10.1021/ACS.JMEDCHEM.7B00359
)
5N1Z
: crystal structure of the bcl6 btb domain in complex with pyrazolo- pyrimidine macrocyclic ligand (
10.1021/ACS.JMEDCHEM.7B00359
)
5N20
: crystal structure of the bcl6 btb domain in complex with pyrazolo- pyrimidine ligand (
10.1021/ACS.JMEDCHEM.7B00359
)
5N21
: crystal structure of the bcl6 btb domain in complex with pyrazolo- pyrimidine ligand (
10.1021/ACS.JMEDCHEM.7B00359
)
5X4M
: crystal structure of the bcl6 btb domain in complex with compound 1 (
10.1021/ACS.JMEDCHEM.7B00313
)
5X4N
: crystal structure of the bcl6 btb domain in complex with compound 4 (
10.1021/ACS.JMEDCHEM.7B00313
)
5X4O
: crystal structure of the bcl6 btb domain in complex with compound 5 (
10.1021/ACS.JMEDCHEM.7B00313
)
5X4P
: crystal structure of the bcl6 btb domain in complex with compound 6 (
10.1021/ACS.JMEDCHEM.7B00313
)
5X4Q
: crystal structure of the bcl6 btb domain in complex with compound 7 (
10.1021/ACS.JMEDCHEM.7B00313
)
5X9O
: crystal structure of the bcl6 btb domain in complex with compound 1a (
10.1016/J.BMC.2017.07.037
)
5X9P
: crystal structure of the bcl6 btb domain in complex with compound 5 (
10.1016/J.BMC.2017.07.037
)
6C3L
: crystal structure of bcl6 btb domain with compound 15f (
10.1021/ACS.JMEDCHEM.8B00040
)
6C3N
: crystal structure of bcl6 btb domain in complex with compound 7cc5 (
10.1021/ACS.JMEDCHEM.8B00040
)
6CQ1
: bcl6 btb domain in complex with 15a (
10.1021/ACS.JMEDCHEM.8B00040
)
6EW6
: crystal structure of the bcl6 btb domain in complex with anilinopyrimidine ligand (
10.1021/ACSCHEMBIO.8B00698
)
6EW7
: crystal structure of the bcl6 btb domain in complex with anilinopyrimidine ligand (
10.1021/ACSCHEMBIO.8B00698
)
6EW8
: crystal structure of the bcl6 btb domain in complex with anilinopyrimidine ligand (
10.1021/ACSCHEMBIO.8B00698
)
6TBT
: crystal structure of the bcl6 btb domain in complex with an apt48 peptide
6TCJ
: crystal structure of the bcl6 btb domain in complex with a hybrid btb- binding (hbp) peptide
6TOF
: crystal structure of human bcl6 btb domain in complex with compound 4 (
10.1021/ACS.JMEDCHEM.9B02076
)
6TOG
: crystal structure of human bcl6 btb domain in complex with compound 5 (
10.1021/ACS.JMEDCHEM.9B02076
)
6TOH
: crystal structure of human bcl6 btb domain in complex with compound 6 (
10.1021/ACS.JMEDCHEM.9B02076
)
6TOI
: crystal structure of human bcl6 btb domain in complex with compound 11f (
10.1021/ACS.JMEDCHEM.9B02076
)
6TOJ
: crystal structure of human bcl6 btb domain in complex with compound 17a (
10.1021/ACS.JMEDCHEM.9B02076
)
6TOK
: crystal structure of human bcl6 btb domain in complex with compound 23d (
10.1021/ACS.JMEDCHEM.9B02076
)
6TOL
: crystal structure of human bcl6 btb domain in complex with compound 25a (
10.1021/ACS.JMEDCHEM.9B02076
)
6TOM
: crystal structure of human bcl6 btb domain in complex with compound 1 (
10.1021/ACS.JMEDCHEM.9B02076
)
6TON
: crystal structure of human bcl6 btb domain in complex with compound 25b (
10.1021/ACS.JMEDCHEM.9B02076
)
6TOO
: crystal structure of human bcl6 btb domain in complex with compound 11a (
10.1021/ACS.JMEDCHEM.9B02076
)
6XMX
: cryo-em structure of bcl6 bound to bi-3802 (
10.1038/S41586-020-2925-1
)
6XWF
: crystal structure of an ncor1bbd2-bcl6btb chimera (
10.1107/S2052252520015754
)
6XXS
: crystal structure of an ncor1bbd2-bcl6btb chimera in complex with the ncor1 bbd1 corepressor peptide. (
10.1107/S2052252520015754
)
6XYX
: crystal structure of the bcl6 btb domain in complex with the ncor1 bbd corepressor peptide (
10.1107/S2052252520015754
)
6XZZ
: crystal structure of the bcl6 btb domain in complex with the ncor1 bbd2 peptide (
10.1107/S2052252520015754
)
6Y17
: crystal structure of an ncor1bbd2-bcl6btb chimera in complex with nebulinsh3-ncor1bbd1 (
10.1107/S2052252520015754
)
6ZBU
: crystal structure of an ncor1bbd2-bcl6btb chimera in complex with the ncor1 bbd1 corepressor peptide (
10.1107/S2052252520015754
)
7BDE
: human bcl6 btb-domain in complex with gsk137 (
10.1016/J.JBC.2021.100928
)
7OKD
: crystal structure of human bcl6 btb domain in complex with compound 25 (
10.1021/ACS.JMEDCHEM.1C00946
)
7OKE
: crystal structure of human bcl6 btb domain in complex with compound 2 (
10.1021/ACS.JMEDCHEM.1C00946
)
7OKF
: crystal structure of human bcl6 btb domain in complex with compound 8c (
10.1021/ACS.JMEDCHEM.1C00946
)
7OKG
: crystal structure of human bcl6 btb domain in complex with compound 8e (
10.1021/ACS.JMEDCHEM.1C00946
)
7OKH
: crystal structure of human bcl6 btb domain in complex with compound 8f (
10.1021/ACS.JMEDCHEM.1C00946
)
7OKI
: crystal structure of human bcl6 btb domain in complex with compound 12b (
10.1021/ACS.JMEDCHEM.1C00946
)
7OKJ
: crystal structure of human bcl6 btb domain in complex with compound 12c and its enantiomer 12b (
10.1021/ACS.JMEDCHEM.1C00946
)
7OKK
: crystal structure of human bcl6 btb domain in complex with compound 12e (
10.1021/ACS.JMEDCHEM.1C00946
)
7OKL
: crystal structure of human bcl6 btb domain in complex with compound 13e (
10.1021/ACS.JMEDCHEM.1C00946
)
7OKM
: crystal structure of human bcl6 btb domain in complex with compound 13g (
10.1021/ACS.JMEDCHEM.1C00946
)