3PBL
Structure of the human dopamine D3 receptor in complex with eticlopride
- PDB DOI: https://doi.org/10.2210/pdb3PBL/pdb
- Classification: HYDROLASE/HYDROLASE INHIBITOR
- Organism(s): Homo sapiens, Tequatrovirus T4
- Expression System: Spodoptera frugiperda
- Mutation(s): Yes
- Membrane Protein: Yes OPMPDBTMMemProtMDmpstruc
- Deposited: 2010-10-20 Released: 2010-11-03
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.89 Å
- R-Value Free: 0.272
- R-Value Work: 0.243
- R-Value Observed: 0.245
This is version 2.1 of the entry. See complete history.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| D(3) dopamine receptor, Lysozyme chimera | 481 | Homo sapiens, Tequatrovirus T4 | Mutation(s): 3 Gene Names: DRD3, E EC: 3.2.1.17 Membrane Entity: Yes |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P35462 (Homo sapiens) Explore P35462 Go to UniProtKB: P35462 | |||||
PHAROS: P35462 GTEx: ENSG00000151577 | |||||
Find proteins for P00720 (Enterobacteria phage T4) Explore P00720 Go to UniProtKB: P00720 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Groups | P00720P35462 | ||||
Sequence AnnotationsExpand | |||||
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Oligosaccharides
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| ETQ Query on ETQ | E [auth A], F [auth B] | 3-chloro-5-ethyl-N-{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-6-hydroxy-2-methoxybenzamide C17 H25 Cl N2 O3 AADCDMQTJNYOSS-LBPRGKRZSA-N |  | ||
Biologically Interesting Molecules (External Reference) 1 Unique
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| ID | Chains | Name | Type/Class | 2D Diagram | 3D Interactions |
| PRD_900001 Query on PRD_900001 | C, D | alpha-maltose | Oligosaccharide / Nutrient |  | |
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.89 Å
- R-Value Free: 0.272
- R-Value Work: 0.243
- R-Value Observed: 0.245
- Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 88.828 | α = 90 |
| b = 92.492 | β = 90 |
| c = 176.116 | γ = 90 |
| Software Name | Purpose |
|---|---|
| Blu-Ice | data collection |
| PHASER | phasing |
| BUSTER | refinement |
| HKL-2000 | data reduction |
| SCALEPACK | data scaling |
Entry History
Deposition Data
- Released Date: 2010-11-03 Deposition Author(s): Chien, E.Y.T., Liu, W., Han, G.W., Katritch, V., Zhao, Q., Cherezov, V., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Revision History (Full details and data files)
- Version 1.0: 2010-11-03
Type: Initial release - Version 1.1: 2011-07-13
Changes: Version format compliance - Version 1.2: 2012-05-09
Changes: Structure summary - Version 1.3: 2017-08-16
Changes: Refinement description, Source and taxonomy - Version 2.0: 2020-07-29
Type: Remediation
Reason: Carbohydrate remediation
Changes: Advisory, Atomic model, Data collection, Database references, Derived calculations, Non-polymer description, Structure summary - Version 2.1: 2023-09-06
Changes: Data collection, Database references, Refinement description, Structure summary
