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Target
Sequence
Name
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Ki
IC50
Kd
EC50
Rate constants
ΔG°
ΔH°
-TΔS°
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Ki
IC50
Kd
EC50
ΔG°
ΔH°
-TΔS°
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rcsb
for Interleukin-1 receptor-associated kinase 4
1WH4
: solution structure of the death domain of interleukin-1 receptor-associated kinase4 (irak4) from mus musculus
2A9I
: molecular structure of the interleukin-1 receptor- associated kinase-4 death domain
2NRU
: crystal structure of irak-4 (
10.1016/J.STR.2006.11.001
)
2NRY
: crystal structure of irak-4 (
10.1016/J.STR.2006.11.001
)
2O8Y
: apo irak4 kinase domain
2OIB
: crystal structure of irak4 kinase domain apo form
2OIC
: crystal structure of irak4 kinase domain complexed with staurosporine
2OID
: crystal structure of irak4 kinase domain complexed with amppnp
3MOP
: the ternary death domain complex of myd88, irak4, and irak2 (
10.1038/NATURE09121
)
4RMZ
: crystal structure of irak-4
4U97
: crystal structure of asymmetric irak4 dimer (
10.1016/J.MOLCEL.2014.08.006
)
4U9A
: sulphur anomalous crystal structure of asymmetric irak4 dimer (
10.1016/J.MOLCEL.2014.08.006
)
4XS2
: irak4-inhibitor co-structure (
10.1016/J.BMCL.2015.03.043
)
4Y73
: crystal structure of irak4 kinase domain with inhibitor (
10.1021/ACSMEDCHEMLETT.5B00107
)
4YO6
: irak4-inhibitor co-structure (
10.1021/ACSMEDCHEMLETT.5B00106
)
4YP8
: irak4-inhibitor co-structure (
10.1021/ACSMEDCHEMLETT.5B00106
)
4ZTL
: irak4-inhibitor co-structure (
10.1021/ACSMEDCHEMLETT.5B00279
)
4ZTM
: irak4-inhibitor co-structure (
10.1021/ACSMEDCHEMLETT.5B00279
)
4ZTN
: irak4-inhibitor co-structure (
10.1021/ACSMEDCHEMLETT.5B00279
)
5K72
: irak4 in complex with compound 21 (
10.1021/ACS.JMEDCHEM.7B01290
)
5K75
: irak4 in complex with compound 1 (
10.1021/ACS.JMEDCHEM.7B01290
)
5K76
: irak4 in complex with compound 28 (
10.1021/ACS.JMEDCHEM.7B01290
)
5K7G
: irak4 in complex with az3862 (
10.1021/ACS.JMEDCHEM.7B01290
)
5K7I
: irak4 in complex with az3864 (
10.1021/ACS.JMEDCHEM.7B01290
)
5KX7
: irak4-inhibitor co-structure (
10.1016/J.BMCL.2016.07.048
)
5KX8
: irak4-inhibitor co-structure (
10.1016/J.BMCL.2016.07.048
)
5T1S
: irak4 kinase - compound 1 co-structure (
10.1016/J.BMCL.2017.04.050
)
5T1T
: irak4 kinase - compound 1 co-structure (
10.1016/J.BMCL.2017.04.050
)
5UIQ
: crystal structure of irak4 in complex with compound 9 (
10.1021/ACS.JMEDCHEM.7B00231
)
5UIR
: crystal structure of irak4 in complex with compound 11 (
10.1021/ACS.JMEDCHEM.7B00231
)
5UIS
: crystal structure of irak4 in complex with compound 12 (
10.1021/ACS.JMEDCHEM.7B00231
)
5UIT
: crystal structure of irak4 in complex with compound 14 (
10.1021/ACS.JMEDCHEM.7B00231
)
5UIU
: crystal structure of irak4 in complex with compound 30 (
10.1021/ACS.JMEDCHEM.7B00231
)
5W84
: crystal structure of irak-4 with a 4,6-diaminonicotinamide inhibitor (compound number 4) (
10.1016/J.BMCL.2017.09.029
)
5W85
: crystal structure of irak-4 with a 4,6-diaminonicotinamide inhibitor (compound number 9) (
10.1016/J.BMCL.2017.09.029
)
6EG9
: irak4 in complex with ponatinib (
10.1074/JBC.RA118.005428
)
6EGA
: irak4 in complex with a type ii inhibitor (
10.1074/JBC.RA118.005428
)
6EGD
: crystal structure of the unphosphorylated irak4 kinase domain bound to a type i inhibitor (
10.1074/JBC.RA118.005428
)
6EGE
: crystal structure of the unphosphorylated irak4 kinase domain bound to a type i inhibitor (
10.1074/JBC.RA118.005428
)
6EGF
: crystal structure of the inactive unphosphorylated irak4 kinase domain bound to amp-pnp (
10.1074/JBC.RA118.005428
)
6F3D
: irak4 in complex with inhibitor (
10.1016/J.BMC.2018.01.008
)
6F3E
: irak4 in complex with inhibitor (
10.1016/J.BMC.2018.01.008
)
6F3G
: irak4 in complex with inhibitor (
10.1016/J.BMC.2018.01.008
)
6F3I
: irak4 in complex with inhibitor (
10.1016/J.BMC.2018.01.008
)
6LXY
: irak4 in complex with inhibitor (
10.1021/ACSMEDCHEMLETT.0C00082
)
6MOM
: crystal structure of human interleukin-1 receptor associated kinase 4 (irak 4, cid 100300) in complex with compound ncc00371481 (bsi 107591) (
10.1126/SCITRANSLMED.AAW8828
)
6N8G
: irak4 bound to benzoxazole compound
6O8U
: crystal structure of irak4 in complex with compound 23 (
10.1021/ACS.JMEDCHEM.9B00439
)
6O94
: structure of the irak4 kinase domain with compound 17 (
10.1021/ACS.JMEDCHEM.9B00439
)
6O95
: structure of the irak4 kinase domain with compound 41 (
10.1021/ACS.JMEDCHEM.9B00439
)
6O9D
: structure of the irak4 kinase domain with compound 5 (
10.1021/ACS.JMEDCHEM.9B00439
)
6RFI
: irak4 in complex with inhibitor (
10.1021/ACS.JMEDCHEM.9B01346
)
6RFJ
: irak4 in complex with inhibitor (
10.1021/ACS.JMEDCHEM.9B01346
)
6THW
: irak4 in complex with inhibitor (
10.1016/J.BMC.2020.115815
)
6THX
: irak4 in complex with inhibitor (
10.1016/J.BMC.2020.115815
)
6THZ
: irak4 in complex with inhibitor (
10.1016/J.BMC.2020.115815
)
6TI8
: irak4 in complex with inhibitor (
10.1016/J.BMC.2020.115815
)
6TIA
: irak4 in complex with inhibitor (
10.1016/J.BMC.2020.115815
)
6UYA
: crystal structure of compound 19 bound to irak4 (
10.1021/ACSMEDCHEMLETT.9B00380
)
6VQL
: crystal structure of interleukin-1 receptor-associated kinase 4 (irak4-wt) complex with a nicotinamide inhibitor (
10.1021/ACSMEDCHEMLETT.0C00082
)
7C2V
: crystal structure of irak4 kinase in complex with the inhibitor ca- 4948 (
10.1021/ACSMEDCHEMLETT.0C00255
)
7C2W
: crystal structure of irak4 kinase in complex with a small molecule inhibitor (
10.1021/ACSMEDCHEMLETT.0C00255
)