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Target
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Ki
IC50
Kd
EC50
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ΔG°
ΔH°
-TΔS°
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rcsb
for Interleukin-17A
2VXS
: structure of il-17a in complex with a potent, fully human neutralising antibody (
10.1016/J.JMB.2009.10.008
)
4HR9
: human interleukin 17a (
10.1038/NCOMMS2880
)
4HSA
: structure of interleukin 17a in complex with il17ra receptor (
10.1038/NCOMMS2880
)
4QHU
: crystal structure of il-17a/fab6785 complex
5HHV
: inhibiting complex il-17a and il-17ra interactions with a linear peptide (
10.1038/SREP26071
)
5HHX
: inhibiting complex il-17a and il-17ra interactions with a linear peptide (
10.1038/SREP26071
)
5HI3
: binding site elucidation and structure guided design of macrocyclic il-17a antagonists (
10.1038/SREP30859
)
5HI4
: binding site elucidation and structure guided design of macrocyclic il-17a antagonists (
10.1038/SREP30859
)
5HI5
: binding site elucidation and structure guided design of macrocyclic il-17a antagonists (
10.1038/SREP30859
)
5N7W
: computationally designed functional antibody (
10.1016/J.CELREP.2018.10.081
)
5N92
: crystal structure of human il-17af (
10.1038/S41598-017-08360-9
)
5NAN
: crystal structure of human il-17af in complex with human il-17ra (
10.1038/S41598-017-08360-9
)
5VB9
: il-17a in complex with peptide (
10.1371/JOURNAL.PONE.0190850
)
6WIO
: fab antigen complex (
10.1371/JOURNAL.PONE.0232311
)
6WIR
: fab antigen complex (
10.1371/JOURNAL.PONE.0232311
)
7AMA
: il-17a in complex with small molecule modulators (
10.1021/ACS.JMEDCHEM.2C00422
)
7AMG
: il-17a in complex with small molecule modulators (
10.1021/ACS.JMEDCHEM.2C00422
)
7WKX
: il-17a in complex with the humanized antibody hb0017 (
10.1016/J.IJBIOMAC.2022.01.119
)