Your request to link to rcsb for Protein arginine N-methyltransferase 5

---

• 4GQB: crystal structure of the human prmt5:mep50 complex (10.1073/PNAS.1209814109 )
• 4X60: crystal structure of prmt5:mep50 with epz015666 and sinefungin (10.1038/NCHEMBIO.1810 )
• 4X61: crystal structure of prmt5:mep50 with epz015666 and sam (10.1038/NCHEMBIO.1810 )
• 4X63: crystal structure of prmt5:mep50 with epz015666 and sah (10.1038/NCHEMBIO.1810 )
• 5C9Z: crystal structure of prmt5:mep50 with epz015866 and sinefungin
• 5EMJ: crystal structure of prmt5:mep50 with compound 8 and sinefungin (10.1021/ACSMEDCHEMLETT.5B00380 )
• 5EMK: crystal structure of prmt5:mep50 with compound 9 and sinefungin (10.1021/ACSMEDCHEMLETT.5B00380 )
• 5EML: crystal structure of prmt5:mep50 with compound 10 and sam (10.1021/ACSMEDCHEMLETT.5B00380 )
• 5EMM: crystal structure of prmt5:mep50 with compound 15 and sinefungin (10.1021/ACSMEDCHEMLETT.5B00380 )
• 5FA5: crystal structure of prmt5:mep50 in complex with mta and h4 peptide (10.1126/SCIENCE.AAD5944 )
• 6CKC: structure of prmt5:mep50 in complex with lly-283, a potent and selective inhibitor of prmt5, with antitumor activity (10.1021/ACSMEDCHEMLETT.8B00014 )
• 6K1S: discovery of potent and selective covalent protein arginine methyltransferase (prmt5) inhibitors (10.1021/ACSMEDCHEMLETT.9B00074 )
• 6RLL: crystal structure of the human prmt5:mep50 complex with jnj44064146
• 6RLQ: crystal structure of the human prmt5:mep50 complex with jnj45031882
• 6UGH: cryo-em structure of the apo form of human prmt5:mep50 complex at a resolution of 3.4 angstrom
• 6UXX: prmt5:mep50 complexed with allosteric inhibitor compound 1a (10.1021/ACSMEDCHEMLETT.9B00525 )
• 6UXY: prmt5:mep50 complexed with allosteric inhibitor compound 8 (10.1021/ACSMEDCHEMLETT.9B00525 )
• 6V0N: prmt5 bound to pbm peptide from riok1 (10.1101/2020.08.22.256347. )
• 6V0O: prmt5 bound to the pbm peptide from picln (10.1101/2020.08.22.256347. )
• 6V0P: prmt5 complex bound to covalent pbm inhibitor brd6711
• 7BOC: crystal structure of the prmt5 tim barrel domain in complex with riok1 peptide (10.1002/CBIC.202100079 )
• 7KIB: prmt5:mep50 complexed with 5,5-bicyclic inhibitor compound 4 (10.1021/ACS.JMEDCHEM.0C02083 )
• 7KIC: prmt5:mep50 complexed with 5,5-bicyclic inhibitor compound 34 (10.1021/ACS.JMEDCHEM.0C02083 )
• 7KID: prmt5:mep50 complexed with 5,5-bicyclic inhibitor compound 72 (10.1021/ACS.JMEDCHEM.0C02083 )
• 7L1G: prmt5-mep50 complexed with sam (10.1021/ACS.JOC.0C02969 )
• 7M05: cryoem structure of prmt5 bound to covalent pbm-site inhibitor brd- 6988 (10.1101/2021.02.03.429644 )
• 7MX7: prmt5:mep50 complexed with inhibitor pf-06939999 (10.1158/1535-7163.MCT-21-0620 )
• 7MXA: prmt5:mep50 complexed with inhibitor pf-06855800 (10.1158/1535-7163.MCT-21-0620 )
• 7MXC: prmt5:mep50 complexed with adenosine (10.1158/1535-7163.MCT-21-0620 )
• 7MXG: prmt5(m420t mutant):mep50 complexed with inhibitor pf-06855800 (10.1158/1535-7163.MCT-21-0620 )
• 7MXN: prmt5(m420t mutant):mep50 complexed with inhibitor pf-06939999 (10.1158/1535-7163.MCT-21-0620 )