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Target
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Ki
IC50
Kd
EC50
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ΔH°
-TΔS°
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rcsb
for XIAP-BIR3
1F9X
: average nmr solution structure of the bir-3 domain of xiap (
10.1074/JBC.M006226200
)
1G3F
: nmr structure of a 9 residue peptide from smac/diablo complexed to the bir3 domain of xiap (
10.1038/35050006
)
1G73
: crystal structure of smac bound to xiap-bir3 domain (
10.1038/35050012
)
1NW9
: structure of caspase-9 in an inhibitory complex with xiap-bir3 (
10.1016/S1097-2765(03)00054-6
)
1TFQ
: nmr structure of an antagonists of the xiap-caspase-9 interaction complexed to the bir3 domain of xiap (
10.1021/JM040037K
)
1TFT
: nmr structure of an antagonists of the xiap-caspase-9 interaction complexed to the bir3 domain of xiap (
10.1021/JM040037K
)
2JK7
: xiap bir3 bound to a smac mimetic (
10.1021/JM8006849
)
2OPY
: smac mimic bound to bir3-xiap (
10.1016/J.BMC.2007.02.010
)
2OPZ
: avpf bound to bir3-xiap (
10.1016/J.BMC.2007.02.010
)
2VSL
: crystal structure of xiap bir3 with a bivalent smac mimetic (
10.1021/BI800785Y
)
3CLX
: crystal structure of xiap bir3 domain in complex with a smac-mimetic compound, smac005 (
10.1016/J.JMB.2008.09.064
)
3CM2
: crystal structure of xiap bir3 domain in complex with a smac-mimetic compound, smac010 (
10.1016/J.JMB.2008.09.064
)
3CM7
: crystal structure of xiap-bir3 domain in complex with smac- mimetic compuond, smac005 (
10.1016/J.JMB.2008.09.064
)
3EYL
: crystal structure of xiap bir3 domain in complex with a smac-mimetic compound (
10.1016/J.BBRC.2008.10.139
)
3G76
: crystal structure of xiap-bir3 in complex with a bivalent compound (
10.1016/J.JMB.2009.04.033
)
3HL5
: crystal structure of xiap bir3 with cs3 (
10.1021/CB900083M
)
4EC4
: xiap-bir3 in complex with a potent divalent smac mimetic (
10.1371/JOURNAL.PONE.0049527
)
4HY0
: crystal structure of xiap bir3 with t3256336 (
10.1021/JM301674Z
)
4KMP
: structure of xiap-bir3 and inhibitor
5C0K
: fragment-based drug discovery targeting inhibitor of apoptosis proteins: compound 3 (
10.1021/ACS.JMEDCHEM.5B00706
)
5C0L
: fragment-based drug discovery targeting inhibitor of apoptosis proteins: compound 2 (
10.1021/ACS.JMEDCHEM.5B00706
)
5C3H
: fragment-based drug discovery targeting inhibitor of apoptosis proteins: compound 1 (
10.1021/ACS.JMEDCHEM.5B00706
)
5C3K
: fragment-based drug discovery targeting inhibitor of apoptosis proteins: compound 4 (
10.1021/ACS.JMEDCHEM.5B00706
)
5C7A
: fragment-based drug discovery targeting inhibitor of apoptosis proteins: compound 7 (
10.1021/ACS.JMEDCHEM.5B00706
)
5C7B
: fragment-based drug discovery targeting inhibitor of apoptosis proteins: compound 5 (
10.1021/ACS.JMEDCHEM.5B00706
)
5C7C
: fragment-based drug discovery targeting inhibitor of apoptosis proteins: compound 18 (
10.1021/ACS.JMEDCHEM.5B00706
)
5C7D
: fragment-based drug discovery targeting inhibitor of apoptosis proteins: compound 17 (
10.1021/ACS.JMEDCHEM.5B00706
)
5C83
: fragment-based drug discovery targeting inhibitor of apoptosis proteins: compound 21 (
10.1021/ACS.JMEDCHEM.5B00706
)
5C84
: fragment-based drug discovery targeting inhibitor of apoptosis proteins: compound 20 (
10.1021/ACS.JMEDCHEM.5B00706
)
5M6E
: small molecule inhibitors of iap (
10.1021/ACS.JMEDCHEM.6B01877
)
5M6F
: small molecule inhibitors of iap (
10.1021/ACS.JMEDCHEM.6B01877
)
5M6H
: small molecule inhibitors of iap (
10.1021/ACS.JMEDCHEM.6B01877
)
5M6L
: small molecule inhibitors of iap (
10.1021/ACS.JMEDCHEM.6B01877
)
5M6M
: small molecule inhibitors of iap (
10.1021/ACS.JMEDCHEM.6B01877
)
5OQW
: xiap in complex with small molecule (
10.1158/1535-7163.MCT-17-0848
)
6EY2
: crystal structure of xiap-bir3 in complex with a ciap1-selective sm (
10.1111/FEBS.14616
)
6H6Q
: fragment derived xiap inhibitor (
10.1021/ACS.JMEDCHEM.8B00900
)
6H6R
: fragment derived xiap inhibitor (
10.1021/ACS.JMEDCHEM.8B00900
)