Binding Database

Please try our new beta-test BindingDB site!

Responsive design for better display on tablests and phones
New tool to filter search results by e.g. target, article, affinity, xtal structure
Simplified new look

Access coronavirus binding data on our covid page here.

BindingDB is a public, web-accessible database of measured binding affinities, focusing chiefly on the interactions of protein considered to be drug-targets with small, drug-like molecules. As of July 24, 2022, BindingDB contains 41,296 Entries, each with a DOI, containing 2,546,129 binding data for 8,821 protein targets and 1,093,579 small molecules.

There are 5,988 protein-ligand crystal structures with BindingDB affinity measurements for proteins with 100% sequence identity, and 11,442 crystal structures allowing proteins to 85% sequence identity.

You can also use BindingDB data through the Registry of Open Data on AWS: https://registry.opendata.aws/binding-db.

Simple Search Article Titles, Authors, Assays, Compound Names, Target Names	Sorry, no hits from this search Use ? for single-letter wild-card or * for general wild-card. For example, "adeny*" or "adeny?". Query cannot start with wild card.

Advanced Search	Combine multiple search criteria, such as chemical structures, target names, and numerical affinities; restrict searches by data source, such as BindingDB, ChEMBL, PubChem, and Patents.

Messages	Recently added Targets Eukaryotic translation initiation factor 4E-binding protein 1, Human, Q13541 (Curated 07/16/22), EIF4EBP1: 1678 subμM ligands Interleukin-17A, Human, Q16552 (Curated 09/07/20), IL17A: 235 subμM ligands BindingDB has accelerated collection of COVID related data. You can find the result here. We are excited to share our new browser extension, BDBFind. Once installed in your browser, BDBFind automatically lets you know when BindingDB has the data from an article, PubMed Entry, or US Patent you are looking at online and provides direct links to view or download the data. Get BDBFind by searching for it in the Chrome webstore or in Firefox extensions or by following these links: https://chrome.google.com/webstore/search/bdbfind (Once installed, click on the "jigsaw puzzle" icon to keep the BDB icon displayed.) https://addons.mozilla.org/addon/bdbfind Watch BDBFind in action in this 1.5 minute video: To send feedback about BDBfind, please email us at bindingdb@gmail.com.

Patent Curation by BindingDB	BindingDB curates US Patents. We have scanned patents back to 2013 for suitable data and are currently up to date as of mid-2020. However, we cannot be sure of capturing all relevant patents, so if you know of a useful one we have missed, please let us know and we will try to curate it. As of July 24, 2022, BindingDB's patent dataset comprises: Patents: 5,805 Binding measurements: 895,898 Compounds: 432,910 Target proteins: 2,304 Assays: 8,386 Average Number of Targets per Patent: 1.91

Journal Curation by BindingDB	BindingDB continually curates a set of journals not covered by other public databases. As of July 24, 2022, the status of our current curation effort is as follows: ACS Chemical Biology 2006-2017 (vol 1-12) ACS BioChemistry 1965-2017 (vol 4-56) Bioorganic Chemistry 1990-2017 (vol 18-73) BMC Chemical Biology 2001-2010 (vol 1-10) ChemBioChem 2001-2017 (vol 2-18) Chemical Biology & Drug Design 2006-2017 (vol 67-89) Chemistry & Biology 1995-2015 (vol 2-22) Journal of Biological Chemistry 1982-2014 (vol 257-289) Journal of Chemical Biology 2010-2010 (vol 3-3) Journal of Enzyme Inhibition and Medicinal Chemistry 2002-2014 (vol 17-29) Nature Chemical Biology 2005-2017 (vol 1-13) Medicinal Chemistry Research 2004-2014 (vol 13-23) PubMed IDs: 3,467 Binding measurements: 112,812 Compounds: 47,154 Target proteins: 2,991 Assays: 3,268

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Video Tutorials	Get all data from an article Download all data for a target of interest Find and view all data for a target of interest Find my compound's targets