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Found 395 with Last Name = 'abboa-offei' and Initial = 'b'
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11542((1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxyadamantan-1...)
Affinity DataKi:  0.600nM ΔG°:  -52.1kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11541((1S,3S,5S)-2-[(2S)-2-(adamantan-1-yl)-2-aminoacety...)
Affinity DataKi:  0.900nM ΔG°:  -51.1kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11530((1S,3S,5S)-2-[(2S)-2-amino-2-(1-ethenylcyclohexyl)...)
Affinity DataKi:  1.40nM ΔG°:  -50.0kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11544((1S,3S,5S)-2-[(2S)-2-amino-2-(3-fluoroadamantan-1-...)
Affinity DataKi:  1.80nM ΔG°:  -49.4kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068673(2'-Formylaminomethyl-4'-isobutyl-biphenyl-2-sulfon...)
Affinity DataKi:  2nMAssay Description:Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50106836(CHEMBL105758 | N-(5-{(R)-2-[(R)-1-(4-Difluorometho...)
Affinity DataKi:  2nMAssay Description:Binding affinity to CHO cells expressing the cloned human beta-3 adrenergic receptor in the presence of [125I]-iodocyanopindololMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50287059((S)-1-(2-Amino-3-methyl-pentanoyl)-pyrrolidine-2-c...)
Affinity DataKi:  2nMAssay Description:In vitro inhibition of porcine Dipeptidylpeptidase IV.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11543((1S,3S,5S)-2-[(2S)-2-amino-2-(3,5-dihydroxyadamant...)
Affinity DataKi:  2.10nM ΔG°:  -49.0kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068706(6-(2-Hydroxy-ethoxy)-4'-isobutyl-biphenyl-2-sulfon...)
Affinity DataKi:  2.70nMAssay Description:Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214244(CHEMBL250978 | N-(5-((R)-4-((R)-1-(3,4-dimethoxyph...)
Affinity DataKi:  3nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11529((1S,3S,5S)-2-[(2S)-2-amino-2-(1-ethenylcyclopentyl...)
Affinity DataKi:  3.90nM ΔG°:  -47.5kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50145999((1S,5S)-2-(2-Amino-2-cyclopentyl-acetyl)-2-aza-bic...)
Affinity DataKi:  4nMAssay Description:In vitro inhibition of porcine Dipeptidylpeptidase IV.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068674(2'-Amino-4'-isobutyl-biphenyl-2-sulfonic acid (3,4...)
Affinity DataKi:  4.70nMAssay Description:Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068720(6-Hydroxy-4'-isobutyl-biphenyl-2-sulfonic acid (3,...)
Affinity DataKi:  5nMAssay Description:Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214246(CHEMBL401135 | N-(5-((R)-4-((R)-1-(4-(difluorometh...)
Affinity DataKi:  5nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068713(4'-Isobutyl-2'-methyl-biphenyl-2-sulfonic acid (3,...)
Affinity DataKi:  5nMAssay Description:Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11535((1S,3S,5S)-2-[(2S)-2-amino-2-(1-ethylcyclopentyl)a...)
Affinity DataKi:  5.5nM ΔG°:  -46.7kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214213(CHEMBL399329 | N-(5-((S)-3-((R)-1-(3,4-dimethoxyph...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214234(CHEMBL250755 | N-(5-((S)-3-((R)-2-(3-chlorophenyl)...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068740(2'-Ethylamino-4'-isobutyl-biphenyl-2-sulfonic acid...)
Affinity DataKi:  6.30nMAssay Description:Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068697(2'-(2-Hydroxy-ethylamino)-4'-isobutyl-biphenyl-2-s...)
Affinity DataKi:  6.40nMAssay Description:Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50146002((S)-2-((S)-2-Amino-3-methyl-3-(S)-methyl-butyryl)-...)
Affinity DataKi:  7nMAssay Description:In vitro inhibition of porcine Dipeptidylpeptidase IV.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214248(CHEMBL437578 | N-(5-((S)-3-((R)-2-(2-chlorophenyl)...)
Affinity DataKi:  7nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214242(CHEMBL447786 | N-(5-((R)-3-((S)-3-(2-chlorophenyl)...)
Affinity DataKi:  7nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50146015((1S,5S)-2-[2-Amino-2-(1-methyl-cyclopentyl)-acetyl...)
Affinity DataKi:  7nMAssay Description:In vitro inhibition of porcine Dipeptidylpeptidase IV.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214240((R)-N-(2-hydroxy-5-(1-hydroxy-2-(2-(4-methoxypheny...)
Affinity DataKi:  7nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11533((1S,3S,5S)-2-[(2S)-2-amino-3,3-dimethylpentanoyl]-...)
Affinity DataKi:  7.10nM ΔG°:  -46.0kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11538((1S,3S,5S)-2-[(2S)-2-amino-2-[1-(hydroxymethyl)cyc...)
Affinity DataKi:  7.40nM ΔG°:  -45.9kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50146009((1S,5S)-2-[2-Amino-2-(1-methyl-cyclohexyl)-acetyl]...)
Affinity DataKi:  8nMAssay Description:In vitro inhibition of porcine Dipeptidylpeptidase IV.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214237(CHEMBL400947 | N-(2-hydroxy-5-((S)-2-hydroxy-3-((R...)
Affinity DataKi:  8nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068736(2'-Hydroxy-4'-isobutyl-biphenyl-2-sulfonic acid (3...)
Affinity DataKi:  8nMAssay Description:Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50151003((S)-1-((S)-2-Amino-3,3-dimethyl-butyryl)-pyrrolidi...)
Affinity DataKi:  8nMAssay Description:In vitro inhibition of porcine Dipeptidylpeptidase IV.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11539((1S,3S,5S)-2-[(2S)-2-amino-2-[1-(hydroxymethyl)cyc...)
Affinity DataKi:  8nM ΔG°:  -45.7kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50106852(CHEMBL321518 | N-{5-[(R)-2-((R)-1-Benzo[1,3]dioxol...)
Affinity DataKi:  8nMAssay Description:Binding affinity to CHO cells expressing the cloned human beta-3 adrenergic receptor in the presence of [125I]-iodocyanopindololMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50148497((S)-N-(4-Chloro-phenyl)-2-[2-hydroxy-2-((R)-4-hydr...)
Affinity DataKi:  8.80nMAssay Description:Binding affinity towards human beta-3 adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214228(CHEMBL400067 | N-(5-((R)-3-((S)-1-(3,4-dimethoxyph...)
Affinity DataKi:  9nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214225(CHEMBL398557 | N-(5-((S)-3-((S)-1-(3,4-dimethoxyph...)
Affinity DataKi:  9nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50106833(CHEMBL317648 | N-(5-{(R)-2-[(R)-1-(4-Difluorometho...)
Affinity DataKi:  9nMAssay Description:Binding affinity to CHO cells expressing the cloned human beta-3 adrenergic receptor in the presence of [125I]-iodocyanopindololMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11532((1S,3S,5S)-2-[(2S)-2-amino-2-(4-ethenyloxan-4-yl)a...)
Affinity DataKi:  10nM ΔG°:  -45.2kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11531((1S,3S,5S)-2-[(2S)-2-amino-2-(1-ethenylcycloheptyl...)
Affinity DataKi:  10nM ΔG°:  -45.2kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50146010((1S,5S)-2-[2-Amino-2-(1-methyl-cyclobutyl)-acetyl]...)
Affinity DataKi:  11nMAssay Description:In vitro inhibition of porcine Dipeptidylpeptidase IV.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50106810(CHEMBL317621 | N-(5-((R)-2-((R)-1-(3,4-dimethoxyph...)
Affinity DataKi:  11nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50148487((S)-2-[2-Hydroxy-2-((R)-4-hydroxy-3-methanesulfony...)
Affinity DataKi:  11nMAssay Description:Binding affinity towards human beta-3 adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50106810(CHEMBL317621 | N-(5-((R)-2-((R)-1-(3,4-dimethoxyph...)
Affinity DataKi:  11nMAssay Description:Binding affinity against CHO cells transfected with human beta-3 adrenergic receptor in the presence of [125I]iodocyanopindololMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50145997((1S,5S)-2-(2-Amino-2-cyclobutyl-acetyl)-2-aza-bicy...)
Affinity DataKi:  12nMAssay Description:In vitro inhibition of porcine Dipeptidylpeptidase IV.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214227(CHEMBL251764 | N-(5-((R)-3-((S)-3-(4-chlorophenyl)...)
Affinity DataKi:  12nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11528((1S,3S,5S)-2-[(2S)-2-amino-2-(1-ethenylcyclobutyl)...)
Affinity DataKi:  12nM ΔG°:  -44.8kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50146007((1R,5S)-3-((S)-2-Amino-3-methyl-butyryl)-3-aza-bic...)
Affinity DataKi:  12nMAssay Description:In vitro inhibition of porcine Dipeptidylpeptidase IV.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068685(4'-Isobutyl-biphenyl-2-sulfonic acid (4,5-dimethyl...)
Affinity DataKi:  13nMAssay Description:Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50146013((1R,5S)-3-((S)-2-Amino-3,3-dimethyl-butyryl)-3-aza...)
Affinity DataKi:  14nMAssay Description:In vitro inhibition of porcine Dipeptidylpeptidase IV.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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