Compile Data Set for Download or QSAR
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Found 623 with Last Name = 'abel' and Initial = 's'
TargetProtein kinase C delta type(Homo sapiens (Human))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50064089(4-hydroxymethyl-7,10-diisopropyl-8,10,13-trimethyl...)
Affinity DataKi:  0.320nMAssay Description:Displacement of [3H]-PDBu from recombinant Protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113787(CHEMBL81056 | S-(2-{2-[2-(4-Carbamimidoyl-phenoxy)...)
Affinity DataKi:  0.370nMAssay Description:In vitro inhibition of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113790(CHEMBL84389 | S-4-{2-[2-(1-Carbamimidoyl-piperidin...)
Affinity DataKi:  0.530nMAssay Description:In vitro inhibition of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113791(CHEMBL84229 | S-4-{2-[2-(1-Carbamimidoyl-piperidin...)
Affinity DataKi:  0.800nMAssay Description:In vitro inhibition of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113785(CHEMBL309670 | RS-(2-{2-[2-(1-Carbamimidoyl-piperi...)
Affinity DataKi:  0.960nMAssay Description:In vitro inhibition of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113799(CHEMBL309403 | S-4-{2-[2-(1-Carbamimidoyl-piperidi...)
Affinity DataKi:  1.10nMAssay Description:In vitro inhibition of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113794(CHEMBL82658 | RS-4-{2-[2-(1-Carbamimidoyl-piperidi...)
Affinity DataKi:  1.30nMAssay Description:In vitro inhibition of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113802(5-{2-[2-(1-Carbamimidoyl-piperidin-4-yloxy)-ethyl]...)
Affinity DataKi:  1.80nMAssay Description:In vitro inhibition of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113792(CHEMBL81521 | S-4-{2-[2-(1-Carbamimidoyl-piperidin...)
Affinity DataKi:  2.17nMAssay Description:In vitro inhibition of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50064090((S)-2-Decyl-5-hydroxymethyl-1-methyl-1,4,5,6-tetra...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-PDBu from recombinant Protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Bos taurus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113792(CHEMBL81521 | S-4-{2-[2-(1-Carbamimidoyl-piperidin...)
Affinity DataKi:  3.30nMAssay Description:Inhibitory effect on plasmin in bovine plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113792(CHEMBL81521 | S-4-{2-[2-(1-Carbamimidoyl-piperidin...)
Affinity DataKi:  4.97nMAssay Description:Inhibitory effect on Coagulation factor Xa (FXa) from bovine plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50064091((2S,5S)-9-Decyl-5-hydroxymethyl-2-isopropyl-1-meth...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]-PDBu from recombinant Protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113798(CHEMBL82535 | RS-4-{2-[2-(1-Carbamimidoyl-piperidi...)
Affinity DataKi:  7.10nMAssay Description:In vitro inhibition of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113796(CHEMBL418923 | S-4-{2-[2-(1-Carbamimidoyl-piperidi...)
Affinity DataKi:  9.80nMAssay Description:In vitro inhibition of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50064092(5'-hydroxymethyl-2'-isopropyl-1',4,4-trimethyl-(2'...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]-PDBu from recombinant Protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113793(1-(2-Ethanesulfonylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataKi:  15nMAssay Description:In vitro inhibition of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113801(CHEMBL81436 | RS-4-{2-[2-(1-Carbamimidoyl-piperidi...)
Affinity DataKi:  16nMAssay Description:In vitro inhibition of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113788(4-{2-[2-(1-Carbamimidoyl-piperidin-4-yloxy)-ethyl]...)
Affinity DataKi:  16nMAssay Description:In vitro inhibition of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50064094(5'-hydroxymethyl-2'-isopropyl-1'-methyl-(2'S,5'S)-...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]-PDBu from recombinant Protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50057510((2S,5S)-8-Decyl-5-hydroxymethyl-2-isopropyl-1-meth...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]-PDBu from recombinant Protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039998(CHEMBL99129 | [(S)-1-((S)-1-Ethylcarbamoyl-butylca...)
Affinity DataKi:  32nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113795(CHEMBL81251 | RS-4-{2-[2-(1-Carbamimidoyl-piperidi...)
Affinity DataKi:  32nMAssay Description:In vitro inhibition of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039995(CHEMBL98777 | [(S)-1-(1-Ethylcarbamoyl-2-phenyl-et...)
Affinity DataKi:  35nMAssay Description:Tested for inhibitory activity on human calpain 2 from placentaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50040007(CHEMBL316932 | [(S)-1-((S)-1-Ethylcarbamoyl-2-phen...)
Affinity DataKi:  36nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Bos taurus)
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039995(CHEMBL98777 | [(S)-1-(1-Ethylcarbamoyl-2-phenyl-et...)
Affinity DataKi:  40nMAssay Description:Tested for inhibitory activity on bovine calpain 2 from heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039994(CHEMBL419898 | [(S)-1-(1-Ethylcarbamoyl-butylcarba...)
Affinity DataKi:  42nMAssay Description:Tested for inhibitory activity on porcine calpain 2 from kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Bos taurus)
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039994(CHEMBL419898 | [(S)-1-(1-Ethylcarbamoyl-butylcarba...)
Affinity DataKi:  50nMAssay Description:Tested for inhibitory activity on bovine calpain 2 from heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039995(CHEMBL98777 | [(S)-1-(1-Ethylcarbamoyl-2-phenyl-et...)
Affinity DataKi:  51nMAssay Description:Tested for inhibitory activity on porcine calpain 2 from kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113786(4-{2-[1-(2-Amino-3-phenyl-propionyl)-piperidin-2-y...)
Affinity DataKi:  56nMAssay Description:In vitro inhibition of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50040009(CHEMBL101791 | {(S)-1-[(S)-1-((S)-1-Ethylcarbamoyl...)
Affinity DataKi:  61nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50064093((7S,10S)-10-Hydroxymethyl-7-isopropyl-4,4,6-trimet...)
Affinity DataKi:  65nMAssay Description:Displacement of [3H]-PDBu from recombinant Protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039994(CHEMBL419898 | [(S)-1-(1-Ethylcarbamoyl-butylcarba...)
Affinity DataKi:  66nMAssay Description:Tested for inhibitory activity on human calpain 1 from erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039994(CHEMBL419898 | [(S)-1-(1-Ethylcarbamoyl-butylcarba...)
Affinity DataKi:  73nMAssay Description:Tested for inhibitory activity on human calpain 2 from placentaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039995(CHEMBL98777 | [(S)-1-(1-Ethylcarbamoyl-2-phenyl-et...)
Affinity DataKi:  74nMAssay Description:Tested for inhibitory activity on human calpain 1 from erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039994(CHEMBL419898 | [(S)-1-(1-Ethylcarbamoyl-butylcarba...)
Affinity DataKi:  78nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039994(CHEMBL419898 | [(S)-1-(1-Ethylcarbamoyl-butylcarba...)
Affinity DataKi:  78nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50290875((S)-13-Hydroxymethyl-10-((S)-isopropyl)-3,9,12-tri...)
Affinity DataKi:  80nMAssay Description:Displacement of [3H]-PDBu from Protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C delta type(Homo sapiens (Human))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50057511((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Affinity DataKi:  80nMAssay Description:Displacement of [3H]-PDBu from recombinant Protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039995(CHEMBL98777 | [(S)-1-(1-Ethylcarbamoyl-2-phenyl-et...)
Affinity DataKi:  89nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113787(CHEMBL81056 | S-(2-{2-[2-(4-Carbamimidoyl-phenoxy)...)
Affinity DataKi:  89nMAssay Description:In vitro inhibition of human trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039995(CHEMBL98777 | [(S)-1-(1-Ethylcarbamoyl-2-phenyl-et...)
Affinity DataKi:  89nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113789(4-{2-[2-(1-Carbamimidoyl-piperidin-4-yloxy)-ethyl]...)
Affinity DataKi:  90nMAssay Description:In vitro inhibition of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039999((S)-2-[(R)-3-((S)-2-Benzyloxycarbonylamino-4-methy...)
Affinity DataKi:  92nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50040000(CHEMBL327974 | {(R)-1-[(S)-1-((S)-1-Ethylcarbamoyl...)
Affinity DataKi:  93nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039993(CHEMBL330186 | [(S)-1-(3-Ethylcarbamoyl-propylcarb...)
Affinity DataKi:  109nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039993(CHEMBL330186 | [(S)-1-(3-Ethylcarbamoyl-propylcarb...)
Affinity DataKi:  109nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50040001((S)-2-((S)-2-Amino-3-phenyl-propionylamino)-4-meth...)
Affinity DataKi:  116nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039996(CHEMBL98950 | Morpholine-4-carboxylic acid [(S)-1-...)
Affinity DataKi:  119nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113784(CHEMBL81844 | R-(2-{2-[2-(4-Carbamimidoyl-phenoxy)...)
Affinity DataKi:  120nMAssay Description:In vitro inhibition of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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