Compile Data Set for Download or QSAR
maximum 50k data
Found 49 with Last Name = 'acton' and Initial = 'dg'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236369((R)-1-morpholino-2-(4-(1-(thiazol-2-ylmethyl)-1H-i...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236369((R)-1-morpholino-2-(4-(1-(thiazol-2-ylmethyl)-1H-i...)
Affinity DataKi:  2.70nMAssay Description:Inhibition of erbB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50432188(CHEMBL2346976)
Affinity DataKi:  2.20E+3nMAssay Description:Displacement of [3H]R1881 from full length androgen receptor in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Rattus norvegicus (Rat))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50432188(CHEMBL2346976)
Affinity DataKi:  5.00E+3nMAssay Description:Binding affinity to rat androgen receptor ligand binding domain by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263148(CHEMBL476578 | N-((R)-1-(4-(5-fluoro-4-(1-isopropy...)
Affinity DataIC50: >0.300nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263147(CHEMBL476577 | N-(1-(4-(5-fluoro-4-(1-isopropyl-2-...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263068(CHEMBL477785 | N-(4-(4-(2-(dimethylamino)ethylsulf...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263026(CHEMBL478407 | N-(4-fluorophenyl)-4-(1-isopropyl-2...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263112(1-(4-(4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imida...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236375((S)-2-(4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human erbB2 autophosphorylation in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236373((R)-2-(4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human erbB2 autophosphorylation in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236370((R)-N,N-dimethyl-2-(4-(1-(pyridin-2-ylmethyl)-1H-i...)
Affinity DataIC50:  8nMAssay Description:Inhibition of erbB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263146(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50262981(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-met...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263113(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-mor...)
Affinity DataIC50:  9nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236381((S)-1-morpholino-2-(4-(1-(thiazol-2-ylmethyl)-1H-i...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human erbB2 autophosphorylation in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263110(2-(dimethylamino)-1-(4-(4-(4-(1-isopropyl-2-methyl...)
Affinity DataIC50:  16nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263070(2-hydroxy-1-(4-(4-(4-(1-isopropyl-2-methyl-1H-imid...)
Affinity DataIC50:  17nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263071((2S)-2-hydroxy-1-(4-(4-(4-(1-isopropyl-2-methyl-1H...)
Affinity DataIC50:  17nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236368((R)-2-(4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human erbB2 autophosphorylation in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50229343((R)-N,N-dimethyl-2-(4-(3-methyl-4-(6-methylpyridin...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human erbB2 autophosphorylation in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50262980(CHEMBL476518 | N1-(4-(1-isopropyl-2-methyl-1H-imid...)
Affinity DataIC50:  24nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236377((S)-N,N-dimethyl-2-(4-(1-(thiazol-2-ylmethyl)-1H-i...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human erbB2 autophosphorylation in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236376((R)-N,N-dimethyl-2-(4-(1-(thiazol-2-ylmethyl)-1H-i...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human erbB2 autophosphorylation in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236383((R)-2-(4-(1-(pyridin-2-ylmethyl)-1H-indazol-5-ylam...)
Affinity DataIC50:  32nMAssay Description:Inhibition of human erbB2 autophosphorylation in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236369((R)-1-morpholino-2-(4-(1-(thiazol-2-ylmethyl)-1H-i...)
Affinity DataIC50:  43nMAssay Description:Inhibition of human erbB2 autophosphorylation in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263149((2S)-1-(4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imi...)
Affinity DataIC50:  46nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236378((R)-1-morpholino-2-(4-(1-(pyridin-2-ylmethyl)-1H-i...)
Affinity DataIC50:  51nMAssay Description:Inhibition of human erbB2 autophosphorylation in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236384((R)-2-(4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)...)
Affinity DataIC50:  57nMAssay Description:Inhibition of human erbB2 autophosphorylation in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236372((R)-N-methyl-2-(4-(1-(pyridin-2-ylmethyl)-1H-indaz...)
Affinity DataIC50:  59nMAssay Description:Inhibition of human erbB2 autophosphorylation in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236367((S)-N,N-dimethyl-2-(4-(1-(pyridin-2-ylmethyl)-1H-i...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human erbB2 autophosphorylation in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236370((R)-N,N-dimethyl-2-(4-(1-(pyridin-2-ylmethyl)-1H-i...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human erbB2 autophosphorylation in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236387((S)-N,N-dimethyl-2-(4-(1-(thiazol-4-ylmethyl)-1H-i...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human erbB2 autophosphorylation in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236379((R)-2-(4-(1-(thiazol-4-ylmethyl)-1H-indazol-5-ylam...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human erbB2 autophosphorylation in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236371((S)-1-morpholino-2-(4-(1-(pyridin-2-ylmethyl)-1H-i...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human erbB2 autophosphorylation in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236380((R)-1-morpholino-2-(4-(1-(thiazol-4-ylmethyl)-1H-i...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human erbB2 autophosphorylation in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236370((R)-N,N-dimethyl-2-(4-(1-(pyridin-2-ylmethyl)-1H-i...)
Affinity DataIC50:  180nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236374((R)-N,N-dimethyl-2-(4-(1-(thiazol-4-ylmethyl)-1H-i...)
Affinity DataIC50:  230nMAssay Description:Inhibition of human erbB2 autophosphorylation in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236388((R)-N-methyl-2-(4-(1-(thiazol-2-ylmethyl)-1H-indaz...)
Affinity DataIC50:  240nMAssay Description:Inhibition of human erbB2 autophosphorylation in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236369((R)-1-morpholino-2-(4-(1-(thiazol-2-ylmethyl)-1H-i...)
Affinity DataIC50:  366nMAssay Description:Inhibition of EGF-stimulated human EGFR autophosphorylation in KB cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263029(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(4-...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263069(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(4-...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263146(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263068(CHEMBL477785 | N-(4-(4-(2-(dimethylamino)ethylsulf...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263112(1-(4-(4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imida...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263070(2-hydroxy-1-(4-(4-(4-(1-isopropyl-2-methyl-1H-imid...)
Affinity DataIC50: >2.40E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263071((2S)-2-hydroxy-1-(4-(4-(4-(1-isopropyl-2-methyl-1H...)
Affinity DataIC50: >2.40E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50236370((R)-N,N-dimethyl-2-(4-(1-(pyridin-2-ylmethyl)-1H-i...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263110(2-(dimethylamino)-1-(4-(4-(4-(1-isopropyl-2-methyl...)
Affinity DataIC50: >3.20E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed