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Found 235 with Last Name = 'adams' and Initial = 'wj'
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116067((Linezolid)N-[3-(3-Fluoro-4-morpholin-4-yl-phenyl)...)
Affinity DataKi:  5.30E+4nMAssay Description:Inhibition of human recombinant MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226485((R)-3-(3-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl...)
Affinity DataKi:  5.80E+4nMAssay Description:Inhibition of human recombinant MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226479((R)-3-(3,5-difluoro-4-morpholinophenyl)-2-oxooxazo...)
Affinity DataKi:  6.30E+4nMAssay Description:Inhibition of human recombinant MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226484((5R)-3-[4-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl...)
Affinity DataKi:  1.05E+5nMAssay Description:Inhibition of human recombinant MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226480((R)-3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidi...)
Affinity DataKi:  1.46E+5nMAssay Description:Inhibition of human recombinant MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226481((5R)-3-[4-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl...)
Affinity DataKi:  2.93E+5nMAssay Description:Inhibition of human recombinant MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226482((5R)-3-[3,5-difluoro-4-(1-oxidotetrahydro-2H-thiop...)
Affinity DataKi:  3.55E+5nMAssay Description:Inhibition of human recombinant MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50064007(6-CHLORO-2-(1-FURO[2,3-C]PYRIDIN-5-YL-ETHYLSULFANY...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity against E233V mutant HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50064007(6-CHLORO-2-(1-FURO[2,3-C]PYRIDIN-5-YL-ETHYLSULFANY...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against wild type HIV-1 reverse transcriptase (WT-RT)More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50064009(6-Chloro-2-(1-furo[2,3-c]pyridin-5-yl-ethylsulfany...)
Affinity DataIC50:  22nMAssay Description:Inhibitory activity against P236L mutant HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50064007(6-CHLORO-2-(1-FURO[2,3-C]PYRIDIN-5-YL-ETHYLSULFANY...)
Affinity DataIC50:  22nMAssay Description:Inhibitory activity against P236L mutant HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50064009(6-Chloro-2-(1-furo[2,3-c]pyridin-5-yl-ethylsulfany...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against wild type HIV-1 reverse transcriptase (WT-RT)More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50064008(6-Chloro-2-((R)-1-furo[2,3-c]pyridin-5-yl-ethylsul...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against P236L mutant HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50064007(6-CHLORO-2-(1-FURO[2,3-C]PYRIDIN-5-YL-ETHYLSULFANY...)
Affinity DataIC50:  39nMAssay Description:Inhibitory activity against L100I mutant HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50064009(6-Chloro-2-(1-furo[2,3-c]pyridin-5-yl-ethylsulfany...)
Affinity DataIC50:  44nMAssay Description:Inhibitory activity against E233V mutant HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50064009(6-Chloro-2-(1-furo[2,3-c]pyridin-5-yl-ethylsulfany...)
Affinity DataIC50:  44nMAssay Description:Inhibitory activity against L100I mutant HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50064009(6-Chloro-2-(1-furo[2,3-c]pyridin-5-yl-ethylsulfany...)
Affinity DataIC50:  55nMAssay Description:Inhibitory activity against Y188H mutant HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50081628(CHEMBL336635 | N-(2-{4-[(3-Ethyl-pyridin-2-yl)-met...)
Affinity DataIC50:  61nMAssay Description:Inhibition of Reverse transcriptase (Wild Type) with poly(rA)600:oligo(dT)10 template primerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50064007(6-CHLORO-2-(1-FURO[2,3-C]PYRIDIN-5-YL-ETHYLSULFANY...)
Affinity DataIC50:  77nMAssay Description:Inhibitory activity against Y188H mutant HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50064008(6-Chloro-2-((R)-1-furo[2,3-c]pyridin-5-yl-ethylsul...)
Affinity DataIC50:  85nMAssay Description:Inhibitory activity against wild type HIV-1 reverse transcriptase (WT-RT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1954((Alkylamino)piperidine BHAP Analog 10 | 1-[(5-Meth...)
Affinity DataIC50:  90nMpH: 8.3 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50081631(CHEMBL336807 | N-(2-{4-[Ethyl-(3-ethyl-pyridin-2-y...)
Affinity DataIC50:  98nMAssay Description:Inhibition of Reverse transcriptase (Wild Type) with poly(rA)600:oligo(dT)10 template primerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027,P823L]/[588-1147,P823L](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1317(3-[[(4,7-Dichlorobenzoxazol-2-yl)-methyl]amino]-5-...)
Affinity DataIC50:  110nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Sptanis Pharmachem Consulting

Curated by ChEMBL
LigandPNGBDBM50030474(Avandamet | Avandaryl | Avandia | BRL-49653 | CHEB...)
Affinity DataIC50:  112nMAssay Description:Competitive displacement of fluorescently labelled PPAR tracer ligand from GST-tagged human PPARgamma ligand binding domain after 1 hr in dark by TR-...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Sptanis Pharmachem Consulting

Curated by ChEMBL
LigandPNGBDBM50150998(((4-Methoxy-phenoxycarbonyl)-{4-[2-(5-methyl-2-phe...)
Affinity DataIC50:  120nMAssay Description:Competitive displacement of fluorescently labelled PPAR tracer ligand from GST-tagged human PPARgamma ligand binding domain after 1 hr in dark by TR-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50081622(CHEMBL132770 | N-(2-{4-[(3-Ethyl-pyridin-2-yl)-pro...)
Affinity DataIC50:  130nMAssay Description:Inhibition of Reverse transcriptase (Wild Type) with poly(rA)600:oligo(dT)10 template primerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1966((Alkylamino)piperidine BHAP Analog 22 | 1-[(5-Meth...)
Affinity DataIC50:  130nMpH: 8.3 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1967((Alkylamino)piperidine BHAP Analog 23 | 1-[[5-[[(4...)
Affinity DataIC50:  140nMpH: 8.3 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1969((Alkylamino)piperidine BHAP Analog 25 | 1-[[5-[[(4...)
Affinity DataIC50:  140nMpH: 8.3 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50081625(CHEMBL134106 | N-(2-{4-[Ethyl-(3-methoxymethyl-pyr...)
Affinity DataIC50:  140nMAssay Description:Inhibition of Reverse transcriptase (Wild Type) with poly(rA)600:oligo(dT)10 template primerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50081624(CHEMBL132491 | N-(2-{4-[(3-Methoxymethyl-pyridin-2...)
Affinity DataIC50:  140nMAssay Description:Inhibition of Reverse transcriptase (Wild Type) with poly(rA)600:oligo(dT)10 template primerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1964((Alkylamino)piperidine BHAP Analog 20 | N-{2-[(4-{...)
Affinity DataIC50:  150nMpH: 8.3 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1955((Alkylamino)piperidine BHAP Analog 11 | 1-[(5-Meth...)
Affinity DataIC50:  160nMpH: 8.3 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1950((Alkylamino)piperidine BHAP Analog 6 | {2-[(4-{met...)
Affinity DataIC50:  170nMpH: 8.3 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM1956((Alkylamino)piperidine BHAP Analog 12 | 1-[(5-Meth...)
Affinity DataIC50:  170nMAssay Description:Inhibition of Reverse transcriptase (P236L) using poly(rA)600:oligo(dT)10 as template primer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50064007(6-CHLORO-2-(1-FURO[2,3-C]PYRIDIN-5-YL-ETHYLSULFANY...)
Affinity DataIC50:  179nMAssay Description:Inhibitory activity against Y181C mutant HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027,P823L]/[588-1147,P823L](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1969((Alkylamino)piperidine BHAP Analog 25 | 1-[[5-[[(4...)
Affinity DataIC50:  180nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1948((Alkylamino)piperidine BHAP analog 4 | 3-methyl-1-...)
Affinity DataIC50:  180nMpH: 8.3 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM2661((Alkylamino)piperidine BHAP Analog 29 | 4-methyl-N...)
Affinity DataIC50:  190nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027,P823L]/[588-1147,P823L](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1956((Alkylamino)piperidine BHAP Analog 12 | 1-[(5-Meth...)
Affinity DataIC50:  200nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50081631(CHEMBL336807 | N-(2-{4-[Ethyl-(3-ethyl-pyridin-2-y...)
Affinity DataIC50:  210nMAssay Description:Inhibition of Reverse transcriptase (P236L) using poly(rA)600:oligo(dT)10 as template primer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027,P823L]/[588-1147,P823L](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1954((Alkylamino)piperidine BHAP Analog 10 | 1-[(5-Meth...)
Affinity DataIC50:  210nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM2668((Alkylamino)piperidine BHAP Analog 36 | 1-[[5-[[(4...)
Affinity DataIC50:  210nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM2659((Alkylamino)piperidine BHAP Analog 27 | 1-[[5-[[(4...)
Affinity DataIC50:  220nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1958((Alkylamino)piperidine BHAP Analog 14 | 1-[(5-Meth...)
Affinity DataIC50:  230nMpH: 8.3 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1945((Alkylamino)piperidine BHAP Analog 1 | 2-N-[1-(1H-...)
Affinity DataIC50:  230nMpH: 8.3 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1957((Alkylamino)piperidine BHAP Analog 13 | 1-[(5-Meth...)
Affinity DataIC50:  240nMpH: 8.3 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027,P823L]/[588-1147,P823L](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1957((Alkylamino)piperidine BHAP Analog 13 | 1-[(5-Meth...)
Affinity DataIC50:  240nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027,P823L]/[588-1147,P823L](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1967((Alkylamino)piperidine BHAP Analog 23 | 1-[[5-[[(4...)
Affinity DataIC50:  240nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1968((Alkylamino)piperidine BHAP Analog 24 | 1-[[5-[[(4...)
Affinity DataIC50:  240nMpH: 8.3 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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