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Found 105 with Last Name = 'al-ashmawy' and Initial = 'aak'
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50:  0.0190nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50:  0.180nMAssay Description:Competitive inhibition of human mTOR using 4EBP1 as substrate in presence of [33gammaP]-ATP after 120 mins by filter binding methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50243194(CHEMBL4097194)
Affinity DataIC50:  0.240nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50243144(CHEMBL4065928)
Affinity DataIC50:  0.400nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50243193(CHEMBL4060651)
Affinity DataIC50: <0.5nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50243339(CHEMBL4089494)
Affinity DataIC50: <0.5nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50243292(CHEMBL4092587)
Affinity DataIC50:  0.570nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50243304(CHEMBL4104902)
Affinity DataIC50:  0.630nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50561775(CHEMBL4792696)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate incubated for 10 mins followed by ATP addition and measured after 30 mins in pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50243145(CHEMBL3109141)
Affinity DataIC50:  1nMAssay Description:Competitive inhibition of human mTOR using 4EBP1 as substrate in presence of [33gammaP]-ATP after 120 mins by filter binding methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50561773(CHEMBL4751330)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate incubated for 10 mins followed by ATP addition and measured after 30 mins in pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50243144(CHEMBL4065928)
Affinity DataIC50:  1.60nMAssay Description:Competitive inhibition of human mTOR using 4EBP1 as substrate in presence of [33gammaP]-ATP after 120 mins by filter binding methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50243176(CHEMBL4081617)
Affinity DataIC50:  1.70nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50243146(CHEMBL4102783)
Affinity DataIC50:  1.90nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25045(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Affinity DataIC50:  2nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
LigandPNGBDBM25045(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate incubated for 10 mins followed by ATP addition and measured after 30 mins in pres...More data for this Ligand-Target Pair
LigandPNGBDBM50561771(CHEMBL4764755)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate incubated for 10 mins followed by ATP addition and measured after 30 mins in pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50243195(CHEMBL4079178)
Affinity DataIC50:  2.5nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50243313(CHEMBL4103534)
Affinity DataIC50:  2.5nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50561776(CHEMBL4759291)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate incubated for 10 mins followed by ATP addition and measured after 30 mins in pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50243196(CHEMBL4087043)
Affinity DataIC50:  2.80nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50429701(AZD-2014 | CHEMBL2336325 | US9102670, 1ap)
Affinity DataIC50:  2.80nMAssay Description:Competitive inhibition of human mTOR using 4EBP1 as substrate in presence of [33gammaP]-ATP after 120 mins by filter binding methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50243293(CHEMBL4088235)
Affinity DataIC50:  2.90nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50243172(CHEMBL4059989)
Affinity DataIC50:  3.30nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50561777(CHEMBL4758082)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate incubated for 10 mins followed by ATP addition and measured after 30 mins in pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50243230(CHEMBL4092840)
Affinity DataIC50:  3.60nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50243304(CHEMBL4104902)
Affinity DataIC50:  3.60nMAssay Description:Competitive inhibition of human mTOR using 4EBP1 as substrate in presence of [33gammaP]-ATP after 120 mins by filter binding methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50243251(CHEMBL4088056)
Affinity DataIC50:  3.70nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50243248(CHEMBL4102715)
Affinity DataIC50:  4.10nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50243143(CHEMBL3109142)
Affinity DataIC50:  5nMAssay Description:Competitive inhibition of human mTOR using 4EBP1 as substrate in presence of [33gammaP]-ATP after 120 mins by filter binding methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50436459(CHEMBL2396661)
Affinity DataIC50:  5nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50243296(CHEMBL4065878)
Affinity DataIC50:  5.40nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50243249(CHEMBL4079272)
Affinity DataIC50:  5.60nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50243246(CHEMBL4064842)
Affinity DataIC50:  5.70nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50243314(CHEMBL4087157)
Affinity DataIC50:  6.10nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50561778(CHEMBL4793846)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate incubated for 10 mins followed by ATP addition and measured after 30 mins in pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50561772(CHEMBL4748452)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate incubated for 10 mins followed by ATP addition and measured after 30 mins in pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50243247(CHEMBL4092544)
Affinity DataIC50:  7.80nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50243253(CHEMBL4095781)
Affinity DataIC50:  8.80nMAssay Description:Competitive inhibition of human mTOR using 4EBP1 as substrate in presence of [33gammaP]-ATP after 120 mins by filter binding methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50243254(CHEMBL4069475)
Affinity DataIC50:  9.90nMAssay Description:Competitive inhibition of human mTOR using 4EBP1 as substrate in presence of [33gammaP]-ATP after 120 mins by filter binding methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50561769(CHEMBL4740323)
Affinity DataIC50:  12nMAssay Description:Inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate incubated for 10 mins followed by ATP addition and measured after 30 mins in pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50243252(CHEMBL4059778)
Affinity DataIC50:  16nMAssay Description:Competitive inhibition of human mTOR using 4EBP1 as substrate in presence of [33gammaP]-ATP after 120 mins by filter binding methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50561774(CHEMBL4740384)
Affinity DataIC50:  17nMAssay Description:Inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate incubated for 10 mins followed by ATP addition and measured after 30 mins in pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50561779(CHEMBL4754159)
Affinity DataIC50:  19nMAssay Description:Inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate incubated for 10 mins followed by ATP addition and measured after 30 mins in pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50243251(CHEMBL4088056)
Affinity DataIC50:  19nMAssay Description:Competitive inhibition of human mTOR using 4EBP1 as substrate in presence of [33gammaP]-ATP after 120 mins by filter binding methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM25045(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Affinity DataIC50:  20nMAssay Description:Competitive inhibition of human mTOR using 4EBP1 as substrate in presence of [33gammaP]-ATP after 120 mins by filter binding methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM25045(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human mTOR using 4EBP1 as substrate after 120 mins by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50243194(CHEMBL4097194)
Affinity DataIC50:  23nMAssay Description:Competitive inhibition of human mTOR using 4EBP1 as substrate in presence of [33gammaP]-ATP after 120 mins by filter binding methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50243231(CHEMBL4072084)
Affinity DataIC50:  26nMAssay Description:Competitive inhibition of human mTOR using 4EBP1 as substrate in presence of [33gammaP]-ATP after 120 mins by filter binding methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50561780(CHEMBL4749535)
Affinity DataIC50:  26nMAssay Description:Inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate incubated for 10 mins followed by ATP addition and measured after 30 mins in pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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