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Found 47 with Last Name = 'alderton' and Initial = 'w'
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Piramed Pharma

LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataKi:  580nM ΔG°:  -35.6kJ/molepH: 7.5 T: 2°CAssay Description:Mammalian target of rapamycin (mTOR) was assayed by monitoring phosphorylation of GFP-4EBP using a homogeneous time-resolved fluorescence resonance e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25021(3-{6-[(dimethylamino)methyl]-4-(morpholin-4-yl)thi...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25022(3-(6-{[(2-methoxyethyl)(methyl)amino]methyl}-4-(mo...)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25019(3-[6-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimid...)
Affinity DataIC50:  6nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25024(3-(6-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-4-...)
Affinity DataIC50:  7nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25018(3-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phe...)
Affinity DataIC50:  8nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25023(3-{6-[(4-methylpiperazin-1-yl)methyl]-4-(morpholin...)
Affinity DataIC50:  10nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25020(3-[7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimid...)
Affinity DataIC50:  21nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346529((R)-azetidine-2-carboximidamide | CHEMBL1783094 | ...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant iNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  33nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
LigandPNGBDBM25027(4-[2-(1H-indazol-4-yl)-6-[(4-methylpiperazin-1-yl)...)
Affinity DataIC50:  44nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  75nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
LigandPNGBDBM25025(4-[2-(1H-indazol-4-yl)thieno[3,2-d]pyrimidin-4-yl]...)
Affinity DataIC50:  102nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346532((R)-pyrrolidine-2-carboximidamide | CHEMBL1783097)
Affinity DataIC50:  120nMAssay Description:Inhibition of human recombinant iNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346528(2,5-dihydro-1H-pyrrole-2-carboximidamide | CHEMBL1...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human recombinant iNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346529((R)-azetidine-2-carboximidamide | CHEMBL1783094 | ...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant iNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346529((R)-azetidine-2-carboximidamide | CHEMBL1783094 | ...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human recombinant eNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346529((R)-azetidine-2-carboximidamide | CHEMBL1783094 | ...)
Affinity DataIC50:  260nMAssay Description:Inhibition of human recombinant nNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346520(CHEMBL1783072 | cyclobutanecarboximidamide)
Affinity DataIC50:  380nMAssay Description:Inhibition of human recombinant iNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  670nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346527(CHEMBL1783092 | pyrrolidine-2-carboximidamide)
Affinity DataIC50:  700nMAssay Description:Inhibition of human recombinant iNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346519(CHEMBL1783071 | cyclopropanecarboximidamide)
Affinity DataIC50:  790nMAssay Description:Inhibition of human recombinant iNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50086467((S)-4-(2-Acetimidoylamino-ethylsulfanyl)-2-amino-b...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human recombinant iNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346529((R)-azetidine-2-carboximidamide | CHEMBL1783094 | ...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human recombinant nNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346529((R)-azetidine-2-carboximidamide | CHEMBL1783094 | ...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human recombinant eNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25026(4-[2-(1H-indazol-6-yl)thieno[3,2-d]pyrimidin-4-yl]...)
Affinity DataIC50:  2.45E+3nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346521(CHEMBL1229853 | cyclopentanecarboximidamide)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of human recombinant iNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346526(CHEMBL1783091 | tetrahydrothiophene-2-carboximidam...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of human recombinant iNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346525(CHEMBL1783090 | tetrahydrofuran-2-carboximidamide)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of human recombinant iNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346533((S)-pyrrolidine-2-carboximidamide | CHEMBL1783098)
Affinity DataIC50:  9.40E+3nMAssay Description:Inhibition of human recombinant iNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Piramed Pharma

LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346531(CHEMBL1783096 | azetidine-3-carboximidamide)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human recombinant iNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346532((R)-pyrrolidine-2-carboximidamide | CHEMBL1783097)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human recombinant nNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346532((R)-pyrrolidine-2-carboximidamide | CHEMBL1783097)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of human recombinant eNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346523(CHEMBL1783074 | piperidine-3-carboximidamide)
Affinity DataIC50:  5.10E+4nMAssay Description:Inhibition of human recombinant iNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346524(CHEMBL1783089 | piperidine-4-carboximidamide)
Affinity DataIC50:  5.80E+4nMAssay Description:Inhibition of human recombinant iNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346522(CHEMBL1783073 | piperidine-2-carboximidamide)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant iNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346533((S)-pyrrolidine-2-carboximidamide | CHEMBL1783098)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant eNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346533((S)-pyrrolidine-2-carboximidamide | CHEMBL1783098)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant nNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50086467((S)-4-(2-Acetimidoylamino-ethylsulfanyl)-2-amino-b...)
Affinity DataIC50:  1.45E+5nMAssay Description:Inhibition of human recombinant nNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50086467((S)-4-(2-Acetimidoylamino-ethylsulfanyl)-2-amino-b...)
Affinity DataIC50:  4.66E+5nMAssay Description:Inhibition of human recombinant eNOS by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346533((S)-pyrrolidine-2-carboximidamide | CHEMBL1783098)
Affinity DataKd: >4.00E+4nMAssay Description:Binding affinity to human recombinant iNOS delta 65 residueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346532((R)-pyrrolidine-2-carboximidamide | CHEMBL1783097)
Affinity DataKd:  630nMAssay Description:Binding affinity to human recombinant iNOS delta 65 residueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed