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Found 74 with Last Name = 'allard' and Initial = 'ml'
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344933((R)-5-ethyl-2-(4-fluorophenyl)-7-isopropyl-1-(3,4,...)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359218(CHEMBL1923313)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344920((R)-1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-2-(...)
Affinity DataIC50:  25nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359221(CHEMBL1923316)
Affinity DataIC50:  25nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359223(CHEMBL1923318)
Affinity DataIC50:  28nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344903((R)-1-(3,4-difluorobenzyl)-2-(6-(3,3-difluoropiper...)
Affinity DataIC50:  28nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344937((R)-1-(3,4-difluorobenzyl)-5-ethyl-2-(4-fluorophen...)
Affinity DataIC50:  29nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344914((R)-1-(3,4-difluorobenzyl)-5-ethyl-2-(6-fluoropyri...)
Affinity DataIC50:  35nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344936((R)-1-(2,4-difluorobenzyl)-5-ethyl-2-(4-fluorophen...)
Affinity DataIC50:  35nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344934((R)-1-(3,5-difluorobenzyl)-5-ethyl-2-(4-fluorophen...)
Affinity DataIC50:  36nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359225(CHEMBL1923320)
Affinity DataIC50:  39nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344918((R)-4-(1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-...)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344913((R)-5-(1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-...)
Affinity DataIC50:  41nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344929((R)-7-tert-butyl-1-(3,4-difluorobenzyl)-5-ethyl-2-...)
Affinity DataIC50:  41nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344907((R)-1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-2-(...)
Affinity DataIC50:  42nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344906((R)-1-(3,4-difluorobenzyl)-2-(6-((2R,6S)-2,6-dimet...)
Affinity DataIC50:  43nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344926((R)-7-sec-butyl-1-(3,4-difluorobenzyl)-5-ethyl-2-(...)
Affinity DataIC50:  43nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359227(CHEMBL1923322)
Affinity DataIC50:  45nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344912((R)-1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-2-(...)
Affinity DataIC50:  50nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359231(CHEMBL1923323)
Affinity DataIC50:  50nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344904((R)-1-(3,4-difluorobenzyl)-2-(6-(4,4-difluoropiper...)
Affinity DataIC50:  51nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344935((R)-5-ethyl-1-(4-fluorobenzyl)-2-(4-fluorophenyl)-...)
Affinity DataIC50:  52nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344928((R)-7-cyclopropyl-1-(3,4-difluorobenzyl)-5-ethyl-2...)
Affinity DataIC50:  52nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359219(CHEMBL1923314)
Affinity DataIC50:  52nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359230(CHEMBL1923326)
Affinity DataIC50:  55nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344910((R)-1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-2-(...)
Affinity DataIC50:  64nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344919((R)-1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-2-(...)
Affinity DataIC50:  64nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344916((R)-5-(1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-...)
Affinity DataIC50:  73nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344905((R)-1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-2-(...)
Affinity DataIC50:  82nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359212(CHEMBL1923307)
Affinity DataIC50:  85nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359217(CHEMBL1923312)
Affinity DataIC50:  91nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359229(CHEMBL1923325)
Affinity DataIC50:  95nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359220(CHEMBL1923315)
Affinity DataIC50:  101nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359222(CHEMBL1923317)
Affinity DataIC50:  104nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359211(CHEMBL1923306)
Affinity DataIC50:  107nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359214(CHEMBL1923309)
Affinity DataIC50:  108nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359224(CHEMBL1923319)
Affinity DataIC50:  110nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344927((R)-7-cyclopentyl-1-(3,4-difluorobenzyl)-5-ethyl-2...)
Affinity DataIC50:  111nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344917((R)-4-(1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-...)
Affinity DataIC50:  114nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344932((R)-1-(cyclopentylmethyl)-5-ethyl-2-(4-fluoropheny...)
Affinity DataIC50:  114nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344923(1-(3,4-difluorobenzyl)-5-ethyl-2-(4-fluorophenyl)-...)
Affinity DataIC50:  117nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344925(1-(3,4-difluorobenzyl)-5-ethyl-2-(4-fluorophenyl)-...)
Affinity DataIC50:  121nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359212(CHEMBL1923307)
Affinity DataIC50:  121nMAssay Description:Antagonist activity at P2X7 receptor in rat whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344911((R)-1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-2-(...)
Affinity DataIC50:  132nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359226(CHEMBL1923321)
Affinity DataIC50:  137nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344902(1,2-dibenzyl-5-ethyl-2',3',5,8-tetrahydrospiro[imi...)
Affinity DataIC50:  140nMAssay Description:Inhibition of PDE11More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344940((R)-1-benzyl-5-ethyl-2-(4-fluorophenyl)-7-isopropy...)
Affinity DataIC50:  141nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344924(1'-(3,4-difluorobenzyl)-5'-ethyl-2'-(4-fluoropheny...)
Affinity DataIC50:  143nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344939((R)-1-benzyl-2-(4-fluorophenyl)-7-isopropyl-5-prop...)
Affinity DataIC50:  158nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359204(CHEMBL1923299)
Affinity DataIC50:  178nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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