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Found 79 with Last Name = 'angelico' and Initial = 'p'
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM571410(US11440922, Example 27 | ethyl (4E)-4-[3-(3- cyano...)
Affinity DataKi:  0.640nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
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Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
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Curated by PDSP Ki Database
LigandPNGBDBM85833(N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]- ethyl]-N...)
Affinity DataKi:  0.700nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM571399(US11440922, Example 19 | ethyl (4E)-4-[3-(2,5- dif...)
Affinity DataKi:  0.890nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571414((3-chlorophenyl){(4E)-4- [3-(3-chlorophenyl)prop-2...)
Affinity DataKi:  0.990nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571398(US11440922, Example 18 | ethyl (4E)-4-[3-(4- chlor...)
Affinity DataKi:  1.01nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571415(US11440922, Example 40 | methyl (4E)-4-[3-(3- chlo...)
Affinity DataKi:  1.29nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571397(US11440922, Example 3 | ethyl (4E)-3,3-dimethyl-4-...)
Affinity DataKi:  1.47nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571425(3-{(3E)-3-[1-(3- chlorobenzoyl)-3,3- dimethylpiper...)
Affinity DataKi:  1.60nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571428(US11440922, Example 128 | {(4E)-4-[3-(3- chlorophe...)
Affinity DataKi:  1.82nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571408(US11440922, Example 22 | ethyl (4E)-3,3-dimethyl-4...)
Affinity DataKi:  1.90nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571433((3-chlorophenyl){(4E)-4- [3-(3-chlorophenyl)prop-2...)
Affinity DataKi:  1.91nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571411(US11440922, Example 28 | ethyl (4E)-4-{3-[3- (cyan...)
Affinity DataKi:  2.12nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571429(US11440922, Example 166 | {(4E)-4-[3-(3- chlorophe...)
Affinity DataKi:  2.24nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571430(US11440922, Example 167 | {(4E)-4-[3-(3- chlorophe...)
Affinity DataKi:  2.42nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571418(US11440922, Example 48 | ethyl (3E)-2,2-dimethyl-3...)
Affinity DataKi:  2.44nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571412(US11440922, Example 31 | ethyl (4E)-4-[3-(4- cyano...)
Affinity DataKi:  2.93nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571427((3-chlorophenyl){(4E)-4- [3-(4-fluorophenyl)prop-2...)
Affinity DataKi:  4.02nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
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TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Recordati

Curated by PDSP Ki Database
LigandPNGBDBM85833(N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]- ethyl]-N...)
Affinity DataKi:  5.70nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM571431((3-chlorophenyl){(4E)-4- [3-(3-hydroxyphenyl)prop-...)
Affinity DataKi:  7.35nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571416(US11440922, Example 43 | {(4E)-4-[3-(3- chlorophen...)
Affinity DataKi:  7.39nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571426((3-chlorophenyl){(4E)-4- {3-[3- (hydroxymethyl)phe...)
Affinity DataKi:  8.05nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571422(US11440922, Example 101 | ethyl (3E)-3-[3-(3- chlo...)
Affinity DataKi:  11.2nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM571413(US11440922, Example 32 | ethyl (4E)-4-[3-(3-cyano-...)
Affinity DataKi:  16.1nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571421(US11440922, Example 91 | ethyl (3E)-3-[3-(4- chlor...)
Affinity DataKi:  16.3nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571424(2-methyl-6-[3-(2,2,6,6- tetramethylpiperidin-4- yl...)
Affinity DataKi:  26.9nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM571409(US11440922, Example 25 | ethyl (4E)-4-[3-(4- metho...)
Affinity DataKi:  28.6nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM571420(US11440922, Example 73 | ethyl (3E)-3-[3-(4- cyano...)
Affinity DataKi:  29.8nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Recordati

Curated by PDSP Ki Database
LigandPNGBDBM85833(N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]- ethyl]-N...)
Affinity DataKi:  81nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM571419(US11440922, Example 64 | methyl (3E)-2,2-dimethyl-...)
Affinity DataKi:  82.9nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Recordati

Curated by PDSP Ki Database
LigandPNGBDBM85833(N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]- ethyl]-N...)
Affinity DataKi:  105nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM571417((2,5-dimethylfuran-3- yl)[(4E)-4-{3-[3- (hydroxyme...)
Affinity DataKi:  323nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571432(3-[(3E)-3-{1-[(2,5- dimethylfuran-3- yl)carbonyl]-...)
Affinity DataKi:  637nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571423((3-chlorophenyl)[(4E)-4- {[5-(3-chlorophenyl)-1H- ...)
Affinity DataKi:  932nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571418(US11440922, Example 48 | ethyl (3E)-2,2-dimethyl-3...)
Affinity DataIC50:  2.02nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM300236(US9593127, Example 10 | tert-butyl 3-[2-(m- tolyl)...)
Affinity DataIC50:  3.65nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM300227(US9593127, Example 1 | tert-butyl 3-[2-(3- chlorop...)
Affinity DataIC50:  3.87nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM300230(3-[2-(3-chlorophenyl)ethynyl]- N-ethyl-N-isopropyl...)
Affinity DataIC50:  6.99nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571410(US11440922, Example 27 | ethyl (4E)-4-[3-(3- cyano...)
Affinity DataIC50:  8.60nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM300238(US9593127, Example 12 | [3-[2-(m-tolyl)ethynyl]- 3...)
Affinity DataIC50:  10.6nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM300234(US9593127, Example 8 | [3-[2-(3-chlorophenyl)ethyn...)
Affinity DataIC50:  12.5nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571412(US11440922, Example 31 | ethyl (4E)-4-[3-(4- cyano...)
Affinity DataIC50:  13.5nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM300240(N,N-diethyl-3-[2-(m- tolyl)ethynyl]-3a,4,5,6a- tet...)
Affinity DataIC50:  14.8nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM300235(US9593127, Example 9 | [3-[2-(3-chlorophenyl)ethyn...)
Affinity DataIC50:  15nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM300237(US9593127, Example 11 | [3-[2-(m-tolyl)ethynyl]- 3...)
Affinity DataIC50:  17nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571415(US11440922, Example 40 | methyl (4E)-4-[3-(3- chlo...)
Affinity DataIC50:  18.2nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM300241(N-methoxy-N-methyl-3-[2-(m- tolyl)ethynyl]-3a,4,5,...)
Affinity DataIC50:  22nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM300232(US9593127, Example 6 | [3-[2-(3-chlorophenyl)ethyn...)
Affinity DataIC50:  24.8nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM300228(US9593127, Example 2 | [3-[2-(3-chlorophenyl)ethyn...)
Affinity DataIC50:  29.6nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571421(US11440922, Example 91 | ethyl (3E)-3-[3-(4- chlor...)
Affinity DataIC50:  31.6nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
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US Patent
LigandPNGBDBM571409(US11440922, Example 25 | ethyl (4E)-4-[3-(4- metho...)
Affinity DataIC50:  31.8nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
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