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Found 193 with Last Name = 'ansell' and Initial = 'j'
TargetProstaglandin G/H synthase 1/2(RAT)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076666(CHEMBL175153 | N-Hydroxy-N-{3-[1-(4-methoxy-phenyl...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against Cyclooxygenase (COX) using broken rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076649(CHEMBL369848 | N-{1-methyl-3-[1-(4-methoxyphenyl)-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against 5-lipoxygenase(5-LO) using broken rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076661(CHEMBL177727 | N-{1-Ethyl-3-[1-(4-methoxy-phenyl)-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against Cyclooxygenase (COX) using broken rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50157204((1E)-1-(3,4-dichlorophenyl)pentan-1-one thiosemica...)
Affinity DataIC50:  19nMAssay Description:Inhibitory concentration against cruzain of Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359218(CHEMBL1923313)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359221(CHEMBL1923316)
Affinity DataIC50:  25nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359223(CHEMBL1923318)
Affinity DataIC50:  28nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50157210((E)-(3,4-dichlorophenyl)(2-phenylcyclopropyl)metha...)
Affinity DataIC50:  30nMAssay Description:Inhibitory concentration against cruzain of Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076637(CHEMBL369252 | N-Hydroxy-N-{3-[1-(4-methoxy-phenyl...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against 5-lipoxygenase (5-LO) in intact rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50114608((1E)-1-(3,4-dichlorophenyl)propan-1-one thiosemica...)
Affinity DataIC50:  30nMAssay Description:Inhibitory concentration against cruzain of Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50157207((1E,2E)-1-(3,4-dichlorophenyl)-3-phenylprop-2-en-1...)
Affinity DataIC50:  30nMAssay Description:Inhibitory concentration against cruzain of Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50157206((1Z)-1-(3,4-dichlorophenyl)-2-phenoxyethan-1-one t...)
Affinity DataIC50:  30nMAssay Description:Inhibitory concentration against cruzain of Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076659(CHEMBL435907 | N-{3-[5-(4-Chloro-phenyl)-1-(4-meth...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against Cyclooxygenase (COX) using broken rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50157207((1E,2E)-1-(3,4-dichlorophenyl)-3-phenylprop-2-en-1...)
Affinity DataIC50:  38nMAssay Description:Inhibitory concentration against rhodesain of Trypanosoma brucei rhodesienceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50157211((E)-(3,4-dichlorophenyl)(4-methylphenyl)methanone ...)
Affinity DataIC50:  38nMAssay Description:Inhibitory concentration against rhodesain of Trypanosoma brucei rhodesienceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359225(CHEMBL1923320)
Affinity DataIC50:  39nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50037791(4-(Hydroxy-{1-[2-(3,4,5-trimethoxy-phenyl)-benzofu...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibition of 5-lipoxygenase (5-HETE) derived from the 9000xg supernatant of RBL broken cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50157211((E)-(3,4-dichlorophenyl)(4-methylphenyl)methanone ...)
Affinity DataIC50:  40nMAssay Description:Inhibitory concentration against cruzain of Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50037795(CHEMBL120885 | Furan-2-carboxylic acid hydroxy-[1-...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibition of 5-lipoxygenase (5-HETE) derived from the 9000xg supernatant of RBL broken cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076650(CHEMBL368682 | N-Hydroxy-N-{3-[1-(4-methoxy-phenyl...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against 5-lipoxygenase (5-LO) in intact rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50157209((1E)-1-(3,4-dichlorophenyl)-3-phenylpropan-1-one t...)
Affinity DataIC50:  40nMAssay Description:Inhibitory concentration against cruzain of Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359227(CHEMBL1923322)
Affinity DataIC50:  45nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50037792(CHEMBL122955 | N-Hydroxy-N-[1-(2-phenyl-benzofuran...)
Affinity DataIC50:  50nMAssay Description:In vitro inhibition of 5-lipoxygenase (5-HETE) derived from the 9000xg supernatant of RBL broken cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50037805(CHEMBL121025 | N-hydroxy-N-[1-[2-(3,4,5-trimethoxy...)
Affinity DataIC50:  50nMAssay Description:In vitro inhibition of 5-lipoxygenase (5-HETE) derived from the 9000xg supernatant of RBL broken cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50037803(4-{[1-(2-Butyl-benzofuran-5-yl)-ethyl]-hydroxy-car...)
Affinity DataIC50:  50nMAssay Description:In vitro inhibition of 5-lipoxygenase (5-HETE) derived from the 9000xg supernatant of RBL broken cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50037807(CHEMBL331626 | N-[1-(2-Butyl-benzofuran-5-yl)-ethy...)
Affinity DataIC50:  50nMAssay Description:In vitro inhibition of 5-lipoxygenase (5-HETE) derived from the 9000xg supernatant of RBL broken cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359231(CHEMBL1923323)
Affinity DataIC50:  50nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076642(2,2,2-Trifluoro-N-hydroxy-N-{3-[1-(4-methoxy-pheny...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against Cyclooxygenase (COX) using broken rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359219(CHEMBL1923314)
Affinity DataIC50:  52nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359230(CHEMBL1923326)
Affinity DataIC50:  55nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076640(CHEMBL173133 | N-Hydroxy-N-{3-[1-(4-methoxy-phenyl...)
Affinity DataIC50:  60nMAssay Description:Inhibitory activity against cyclooxygenase (COX) in intact rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50037793(4-{Hydroxy-[1-(2-phenyl-benzofuran-5-yl)-ethyl]-ca...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibition of 5-lipoxygenase (5-HETE) derived from the 9000xg supernatant of RBL broken cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50157210((E)-(3,4-dichlorophenyl)(2-phenylcyclopropyl)metha...)
Affinity DataIC50:  60nMAssay Description:Inhibitory concentration against rhodesain of Trypanosoma brucei rhodesienceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50157204((1E)-1-(3,4-dichlorophenyl)pentan-1-one thiosemica...)
Affinity DataIC50:  60nMAssay Description:Inhibitory concentration against rhodesain of Trypanosoma brucei rhodesienceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076639(CHEMBL367010 | N-{3-[5-(4-Ethyl-phenyl)-1-(4-metho...)
Affinity DataIC50:  60nMAssay Description:Inhibitory activity against Cyclooxygenase (COX) using broken rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076657(CHEMBL368546 | N-hydroxy-N-{3-[1-(4-methoxyphenyl)...)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against 5-lipoxygenase (5-LO) using broken rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50157206((1Z)-1-(3,4-dichlorophenyl)-2-phenoxyethan-1-one t...)
Affinity DataIC50:  70nMAssay Description:Inhibitory concentration against rhodesain of Trypanosoma brucei rhodesienceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076657(CHEMBL368546 | N-hydroxy-N-{3-[1-(4-methoxyphenyl)...)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against 5-lipoxygenase (5-LO) in intact rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076644(CHEMBL175150 | N-{1-ethyl-3-[1-(4-methoxyphenyl)-5...)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against 5-lipoxygenase(5-LO) using broken rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076664(CHEMBL368145 | N-hydroxy-N-{3-[1-(4-methoxyphenyl)...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against 5-lipoxygenase (5-LO) using broken rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50157205((1E)-1-(3,4-dichlorophenyl)-2-phenylethan-1-one th...)
Affinity DataIC50:  80nMAssay Description:Inhibitory concentration against cruzain of Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50157205((1E)-1-(3,4-dichlorophenyl)-2-phenylethan-1-one th...)
Affinity DataIC50:  80nMAssay Description:Inhibitory concentration against rhodesain of Trypanosoma brucei rhodesienceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076664(CHEMBL368145 | N-hydroxy-N-{3-[1-(4-methoxyphenyl)...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against 5-lipoxygenase (5-LO) using broken rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076666(CHEMBL175153 | N-Hydroxy-N-{3-[1-(4-methoxy-phenyl...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against 5-lipoxygenase(5-LO) using broken rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359212(CHEMBL1923307)
Affinity DataIC50:  85nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50157209((1E)-1-(3,4-dichlorophenyl)-3-phenylpropan-1-one t...)
Affinity DataIC50:  90nMAssay Description:Inhibitory concentration against rhodesain of Trypanosoma brucei rhodesienceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076650(CHEMBL368682 | N-Hydroxy-N-{3-[1-(4-methoxy-phenyl...)
Affinity DataIC50:  90nMAssay Description:Inhibitory activity against 5-lipoxygenase (5-LO) in intact rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359217(CHEMBL1923312)
Affinity DataIC50:  91nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50359229(CHEMBL1923325)
Affinity DataIC50:  95nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL1-beta production treated 30 mins be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076650(CHEMBL368682 | N-Hydroxy-N-{3-[1-(4-methoxy-phenyl...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against 5-lipoxygenase(5-LO) using broken rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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