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Found 87 with Last Name = 'aoyama' and Initial = 'y'
TargetCathepsin G(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50101132(1,3-Dibenzyl-[1,3]diazetidine-2,4-dione | CHEMBL47...)
Affinity DataIC50:  0.390nMAssay Description:Compound was evaluated for its inhibitory activity against human cathepsin GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-C(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50101132(1,3-Dibenzyl-[1,3]diazetidine-2,4-dione | CHEMBL47...)
Affinity DataIC50:  0.690nMAssay Description:Compound was evaluated for its inhibitory activity against bovine pancreatic alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50101136(1,3-Bis-benzo[1,3]dioxol-5-ylmethyl-[1,3]diazetidi...)
Affinity DataIC50:  0.850nMAssay Description:Compound was evaluated for its inhibitory activity against human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50101135(1,3-Bis-(4-methoxy-benzyl)-[1,3]diazetidine-2,4-di...)
Affinity DataIC50:  2nMAssay Description:Compound was evaluated for its inhibitory activity against human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50101131(1,3-Di-p-tolyl-[1,3]diazetidine-2,4-dione | CHEMBL...)
Affinity DataIC50:  2.30nMAssay Description:Compound was evaluated for its inhibitory activity against human cathepsin GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50101137(1,3-Bis-(3-methoxy-benzyl)-[1,3]diazetidine-2,4-di...)
Affinity DataIC50:  2.30nMAssay Description:Compound was evaluated for its inhibitory activity against human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-C(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50101131(1,3-Di-p-tolyl-[1,3]diazetidine-2,4-dione | CHEMBL...)
Affinity DataIC50:  2.40nMAssay Description:Compound was evaluated for its inhibitory activity against bovine pancreatic alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50101132(1,3-Dibenzyl-[1,3]diazetidine-2,4-dione | CHEMBL47...)
Affinity DataIC50:  4nMAssay Description:Compound was evaluated for its inhibitory activity against human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093750((6R,7R)-3-(1-Carboxymethyl-1H-tetrazol-5-ylsulfany...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093722((6R,7R)-3-(4-Carboxymethyl-4H-[1,2,4]triazol-3-yls...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093751((6R,7R)-7-Methoxy-7-(2-methoxy-benzoylamino)-3-(1-...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093749((6R,7R)-7-Methoxy-3-(1-methyl-1H-tetrazol-5-ylsulf...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093747((6R,7R)-7-(2-sec-Butoxy-benzoylamino)-7-methoxy-3-...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093745((6R,7R)-7-(2-Ethoxy-benzoylamino)-7-methoxy-3-(1-m...)
Affinity DataIC50:  27nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093745((6R,7R)-7-(2-Ethoxy-benzoylamino)-7-methoxy-3-(1-m...)
Affinity DataIC50:  27nMAssay Description:Compound was evaluated for its inhibitory activity against human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093746((6R,7R)-7-(2-Isopropoxy-benzoylamino)-7-methoxy-3-...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50101132(1,3-Dibenzyl-[1,3]diazetidine-2,4-dione | CHEMBL47...)
Affinity DataIC50:  39nMAssay Description:Compound was evaluated for its inhibitory activity against bovine pancreatic trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50101134(1,3-Bis-benzo[1,3]dioxol-5-yl-[1,3]diazetidine-2,4...)
Affinity DataIC50:  48nMAssay Description:Compound was evaluated for its inhibitory activity against human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093718((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093734((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093748((6R,7R)-7-Methoxy-3-(1-methyl-1H-tetrazol-5-ylsulf...)
Affinity DataIC50:  57nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50101133(1,3-Diethyl-[1,3]diazetidine-2,4-dione | CHEMBL298...)
Affinity DataIC50:  58nMAssay Description:Compound was evaluated for its inhibitory activity against human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093741((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50101132(1,3-Dibenzyl-[1,3]diazetidine-2,4-dione | CHEMBL47...)
Affinity DataIC50:  72nMAssay Description:Compound was evaluated for its inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093716((6R,7R)-3-(1-Carboxymethyl-1H-tetrazol-5-ylsulfany...)
Affinity DataIC50:  72nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093735((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  77nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093716((6R,7R)-3-(1-Carboxymethyl-1H-tetrazol-5-ylsulfany...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093716((6R,7R)-3-(1-Carboxymethyl-1H-tetrazol-5-ylsulfany...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50101132(1,3-Dibenzyl-[1,3]diazetidine-2,4-dione | CHEMBL47...)
Affinity DataIC50:  100nMAssay Description:Compound was evaluated for its inhibitory activity against human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093736((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50101131(1,3-Di-p-tolyl-[1,3]diazetidine-2,4-dione | CHEMBL...)
Affinity DataIC50:  140nMAssay Description:Compound was evaluated for its inhibitory activity against human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093731((6R,7R)-3-Chloromethyl-7-[2-(4-hydroxy-phenyl)-ace...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093745((6R,7R)-7-(2-Ethoxy-benzoylamino)-7-methoxy-3-(1-m...)
Affinity DataIC50:  160nMAssay Description:Inhibitory concentration of the compound was measured against alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-C(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093722((6R,7R)-3-(4-Carboxymethyl-4H-[1,2,4]triazol-3-yls...)
Affinity DataIC50:  160nMAssay Description:The compound was evaluated for the inhibitory activity against alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093742((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  170nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50101131(1,3-Di-p-tolyl-[1,3]diazetidine-2,4-dione | CHEMBL...)
Affinity DataIC50:  200nMAssay Description:Compound was evaluated for its inhibitory activity against bovine pancreatic trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093722((6R,7R)-3-(4-Carboxymethyl-4H-[1,2,4]triazol-3-yls...)
Affinity DataIC50:  230nMAssay Description:The compound was evaluated for the inhibitory activity against cathepsin GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50101131(1,3-Di-p-tolyl-[1,3]diazetidine-2,4-dione | CHEMBL...)
Affinity DataIC50:  230nMAssay Description:Compound was evaluated for its inhibitory activity against human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093720((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093720((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  250nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093745((6R,7R)-7-(2-Ethoxy-benzoylamino)-7-methoxy-3-(1-m...)
Affinity DataIC50:  280nMAssay Description:Inhibitory concentration of the compound was measured against cathepsin GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093726((6R,7R)-7-Methoxy-7-[2-(4-methoxy-phenyl)-acetylam...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093729((6R,7R)-7-Methoxy-3-(1-methyl-2,3-dihydro-1H-tetra...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093730((6R,7R)-7-[2-(4-Dimethylamino-phenyl)-acetylamino]...)
Affinity DataIC50:  410nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093730((6R,7R)-7-[2-(4-Dimethylamino-phenyl)-acetylamino]...)
Affinity DataIC50:  410nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093717((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  430nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093722((6R,7R)-3-(4-Carboxymethyl-4H-[1,2,4]triazol-3-yls...)
Affinity DataIC50:  430nMAssay Description:The compound was evaluated for the inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093722((6R,7R)-3-(4-Carboxymethyl-4H-[1,2,4]triazol-3-yls...)
Affinity DataIC50:  440nMAssay Description:The compound was evaluated for the inhibitory activity against trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093735((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  440nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093734((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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