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Found 91 with Last Name = 'appleby' and Initial = 'sd'
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50057826((S)-1-((R)-2-Amino-3,3-dicyclohexyl-propionyl)-pyr...)
Affinity DataKi:  0.0560nMAssay Description:Inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50056772((S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataKi:  0.0900nMAssay Description:In vitro inhibition of the compound against human thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50454822(CHEMBL2062141 | L-370518)
Affinity DataKi:  0.0900nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50057828((S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrroli...)
Affinity DataKi:  0.100nMAssay Description:Inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50057828((S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrroli...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50057827(((R)-2-{(S)-2-[(4-Amino-cyclohexylmethyl)-carbamoy...)
Affinity DataKi:  0.100nMAssay Description:Inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060708((S)-1-(3-Benzo[1,3]dioxol-5-yl-3-pyridin-3-yl-prop...)
Affinity DataKi:  0.280nM Koff:  2.51E+3s-1Assay Description:Inhibition of ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164268((S)-1-(9-Hydroxy-9H-fluorene-9-carbonyl)-pyrrolidi...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060705((S)-1-(3,3-Diphenyl-propionyl)-pyrrolidine-2-carbo...)
Affinity DataKi:  2nM Koff:  2.10E+3s-1Assay Description:Inhibition of ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062634((S)-1-[3-(4-Hydroxy-phenyl)-2-phenyl-propionyl]-py...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062623((S)-1-[2-Hydroxy-2-(4-hydroxy-3-methoxy-phenyl)-ac...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062628((S)-1-((S)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060704((S)-1-(2-5H-Dibenzo[a,d]cyclohepten-5-yl-acetyl)-p...)
Affinity DataKi:  3nM Koff:  1.80E+3s-1Assay Description:Inhibition of ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060703((S)-1-(3-Phenyl-3-pyridin-4-yl-propionyl)-pyrrolid...)
Affinity DataKi:  3.40nM Koff:  1.55E+3s-1Assay Description:Inhibition of ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366827(CHEMBL125181 | L-371912)
Affinity DataKi:  4.90nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50056771((2S)-N-[(4-aminocyclohexyl)methyl]-1-[(2R)-2-(meth...)
Affinity DataKi:  5nMAssay Description:In vitro inhibition of the compound against human thrombin was determinedMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060706((S)-1-(3-Cyclohexyl-3-phenyl-propionyl)-pyrrolidin...)
Affinity DataKi:  8nMAssay Description:Inhibition of ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060707((S)-1-(3-Phenyl-3-pyridin-3-yl-propionyl)-pyrrolid...)
Affinity DataKi:  10nM Koff:  2.10E+3s-1Assay Description:Inhibition of ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060709((S)-1-(3-Phenyl-3-pyridin-2-yl-propionyl)-pyrrolid...)
Affinity DataKi:  12nM Koff:  1.80E+3s-1Assay Description:Inhibition of ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060711((S)-1-(3,3-Dicyclohexyl-propionyl)-pyrrolidine-2-c...)
Affinity DataKi:  14nM Koff:  2.30E+3s-1Assay Description:Inhibition of ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060710((S)-1-(3,3-Diphenyl-butyryl)-pyrrolidine-2-carboxy...)
Affinity DataKi:  16nMAssay Description:Inhibition of ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060712((S)-1-(2-10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-...)
Affinity DataKi:  17nMAssay Description:Inhibition of ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062624((S)-1-(2,3-Dihydro-benzo[1,4]dioxine-2-carbonyl)-p...)
Affinity DataKi:  75nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50057828((S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrroli...)
Affinity DataKi:  94nMAssay Description:Inhibitory activity against human trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50057826((S)-1-((R)-2-Amino-3,3-dicyclohexyl-propionyl)-pyr...)
Affinity DataKi:  120nMAssay Description:Inhibitory activity of the compound against human serine protease (Trypsin)(2143*)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060705((S)-1-(3,3-Diphenyl-propionyl)-pyrrolidine-2-carbo...)
Affinity DataKi:  350nMAssay Description:In vitro inhibition of human trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50057829((S)-1-((S)-2-Amino-3,3-dicyclohexyl-propionyl)-pyr...)
Affinity DataKi:  440nMAssay Description:Inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164268((S)-1-(9-Hydroxy-9H-fluorene-9-carbonyl)-pyrrolidi...)
Affinity DataKi:  860nMAssay Description:Binding affinity towards trypsin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50056772((S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataKi:  1.15E+3nMAssay Description:In vitro inhibition of the compound against bovine trypsin was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060704((S)-1-(2-5H-Dibenzo[a,d]cyclohepten-5-yl-acetyl)-p...)
Affinity DataKi:  1.60E+3nMAssay Description:In vitro inhibition of human trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060706((S)-1-(3-Cyclohexyl-3-phenyl-propionyl)-pyrrolidin...)
Affinity DataKi:  1.70E+3nMAssay Description:In vitro inhibition of human trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060703((S)-1-(3-Phenyl-3-pyridin-4-yl-propionyl)-pyrrolid...)
Affinity DataKi:  2.20E+3nMAssay Description:In vitro inhibition of human trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060711((S)-1-(3,3-Dicyclohexyl-propionyl)-pyrrolidine-2-c...)
Affinity DataKi:  2.50E+3nMAssay Description:In vitro inhibition of human trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060708((S)-1-(3-Benzo[1,3]dioxol-5-yl-3-pyridin-3-yl-prop...)
Affinity DataKi:  2.60E+3nMAssay Description:In vitro inhibition of human trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060707((S)-1-(3-Phenyl-3-pyridin-3-yl-propionyl)-pyrrolid...)
Affinity DataKi:  2.80E+3nMAssay Description:In vitro inhibition of human trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50057830(((S)-2-{(S)-2-[(4-Amino-cyclohexylmethyl)-carbamoy...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060709((S)-1-(3-Phenyl-3-pyridin-2-yl-propionyl)-pyrrolid...)
Affinity DataKi:  5.00E+3nMAssay Description:In vitro inhibition of human trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50057826((S)-1-((R)-2-Amino-3,3-dicyclohexyl-propionyl)-pyr...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibitory activity of the compound against human serine protease (plasma Kallikrein)(89000*)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50056771((2S)-N-[(4-aminocyclohexyl)methyl]-1-[(2R)-2-(meth...)
Affinity DataKi:  1.10E+4nMAssay Description:In vitro inhibition of the compound against bovine trypsin was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060710((S)-1-(3,3-Diphenyl-butyryl)-pyrrolidine-2-carboxy...)
Affinity DataKi:  1.70E+4nMAssay Description:In vitro inhibition of human trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060711((S)-1-(3,3-Dicyclohexyl-propionyl)-pyrrolidine-2-c...)
Affinity DataKi:  8.40E+4nMAssay Description:Inhibitory activity against serine protease TPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50057826((S)-1-((R)-2-Amino-3,3-dicyclohexyl-propionyl)-pyr...)
Affinity DataKi:  9.50E+4nMAssay Description:Inhibitory activity of the compound against human serine protease Coagulation factor X (1.7*10e6*)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50057826((S)-1-((R)-2-Amino-3,3-dicyclohexyl-propionyl)-pyr...)
Affinity DataKi:  1.37E+5nMAssay Description:Inhibitory activity of the compound against human serine protease (TPA) (2.5*10e6*)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50057826((S)-1-((R)-2-Amino-3,3-dicyclohexyl-propionyl)-pyr...)
Affinity DataKi:  1.65E+5nMAssay Description:Inhibitory activity of the compound against human serine protease (plasmin) (3.0*10e6)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060711((S)-1-(3,3-Dicyclohexyl-propionyl)-pyrrolidine-2-c...)
Affinity DataKi:  1.70E+5nMAssay Description:Inhibitory activity against serine protease plasma kallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060711((S)-1-(3,3-Dicyclohexyl-propionyl)-pyrrolidine-2-c...)
Affinity DataKi:  1.76E+5nMAssay Description:Inhibitory activity against serine protease plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060711((S)-1-(3,3-Dicyclohexyl-propionyl)-pyrrolidine-2-c...)
Affinity DataKi:  2.20E+5nMAssay Description:Inhibitory activity against serine protease Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060704((S)-1-(2-5H-Dibenzo[a,d]cyclohepten-5-yl-acetyl)-p...)
Affinity DataKi:  2.68E+5nMAssay Description:Inhibitory activity against serine protease TPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060709((S)-1-(3-Phenyl-3-pyridin-2-yl-propionyl)-pyrrolid...)
Affinity DataKi:  3.70E+5nMAssay Description:Inhibitory activity against serine protease Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060703((S)-1-(3-Phenyl-3-pyridin-4-yl-propionyl)-pyrrolid...)
Affinity DataKi:  4.00E+5nMAssay Description:Inhibitory activity against serine protease Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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