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Found 257 with Last Name = 'appleby' and Initial = 't'
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Selcia

Curated by ChEMBL
LigandPNGBDBM50230294(CHEMBL4071740)
Affinity DataKi:  4nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Selcia

Curated by ChEMBL
LigandPNGBDBM50230211(CHEMBL4063126)
Affinity DataKi:  4.30nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Selcia

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataKi:  6.70nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Selcia

Curated by ChEMBL
LigandPNGBDBM50230212(CHEMBL4084776)
Affinity DataKi:  7nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Selcia

Curated by ChEMBL
LigandPNGBDBM50230213(CHEMBL4092526)
Affinity DataKi:  14nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Selcia

Curated by ChEMBL
LigandPNGBDBM50230210(CHEMBL4090107)
Affinity DataKi:  16nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Selcia

Curated by ChEMBL
LigandPNGBDBM50230209(CHEMBL4100272)
Affinity DataKi:  65nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Selcia

Curated by ChEMBL
LigandPNGBDBM50230293(CHEMBL4082253)
Affinity DataKi:  795nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50196392(3-hydroxy-N-(2-hydroxy-1-methyl-ethyl)-5-(4-phenyl...)
Affinity DataIC50:  13nMAssay Description:Inhibition of CHK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194053(5-4-2,3-difluorophenoxy)phenylamino)-3-hydroxy-N-1...)
Affinity DataIC50:  20nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194048(5-4-3,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-1...)
Affinity DataIC50:  20nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194024(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Affinity DataIC50:  26nMAssay Description:Inhibition of MEK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194030(5-4-2,5-dichlorophenoxy)-3-fluorophenylamino)-3-hy...)
Affinity DataIC50:  26nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194056(5-3-chloro-4-2,3-dichlorophenoxy)phenylamino)-3-hy...)
Affinity DataIC50:  27nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194039(5-4-2-chloro-3,5-difluorophenoxy)-3-fluorophenylam...)
Affinity DataIC50:  27nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194041(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Affinity DataIC50:  28nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194061(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-1...)
Affinity DataIC50:  30nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194036(5-3-chloro-4-2-chloro-5-fluorophenoxy)phenylamino)...)
Affinity DataIC50:  30nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194051(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-m...)
Affinity DataIC50:  32nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194024(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Affinity DataIC50:  33nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194023(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-t...)
Affinity DataIC50:  34nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194031(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-4...)
Affinity DataIC50:  34nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194026(5-4-2,5-dichlorophenoxy)phenylamino)-N-3,4-dihydro...)
Affinity DataIC50:  34nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194045(5-4-2,5-dichlorophenoxy)phenylamino)-N-1,3-dihydro...)
Affinity DataIC50:  35nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194065(5-4-2-chloro-3,5-difluorophenoxy)phenylamino)-3-hy...)
Affinity DataIC50:  37nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50187848(5-(2,3-dichlorophenylamino)-3-hydroxy-N-(1-hydroxy...)
Affinity DataIC50:  38nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194034(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Affinity DataIC50:  40nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194046(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-1...)
Affinity DataIC50:  40nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50187817(5-(2-chloro-4-iodophenylamino)-3-hydroxy-N-isoprop...)
Affinity DataIC50:  42nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194063(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Affinity DataIC50:  44nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194016(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-3-trifluorom...)
Affinity DataIC50:  44nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194062(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenylthio)p...)
Affinity DataIC50:  45nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194028(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Affinity DataIC50:  46nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194055(5-4-2,5-dichlorophenoxy)phenylamino)-N-2,3-dihydro...)
Affinity DataIC50:  46nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Valeant Pharmaceuticals Research And Development

LigandPNGBDBM26673(6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dih...)
Affinity DataIC50:  50nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194059(5-4-2-chloro-3-trifluoromethyl)phenoxy)-3-fluoroph...)
Affinity DataIC50:  52nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194019(5-4-2,5-dichlorophenoxy)phenylamino)-N-2,3-dihydro...)
Affinity DataIC50:  56nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194033(5-4-2-chloro-4-fluorophenoxy)-2-methylphenylamino)...)
Affinity DataIC50:  57nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194050(5-4-benzylphenylamino)-3-hydroxy-N-1-hydroxypropan...)
Affinity DataIC50:  58nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194025(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Affinity DataIC50:  58nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194058(5-4-2-fluoro-3-trifluoromethyl)phenoxy)phenylamino...)
Affinity DataIC50:  58nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194022(5-4-2-fluoro-5-trifluoromethyl)phenoxy)phenylamino...)
Affinity DataIC50:  60nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50187841(3-hydroxy-5-(4-iodo-2-methylphenylamino)-N-isoprop...)
Affinity DataIC50:  62nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194057(5-4-2,4-dichlorophenoxy)phenylamino)-3-hydroxy-N-1...)
Affinity DataIC50:  64nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194064(5-3-chloro-4-2-chloro-3-trifluoromethyl)phenoxy)ph...)
Affinity DataIC50:  67nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194040(5-4-2,3-dichlorophenoxy)phenylamino)-3-hydroxy-N-1...)
Affinity DataIC50:  75nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194021(5-4-2-chloro-5-fluorophenoxy)phenylamino)-3-hydrox...)
Affinity DataIC50:  80nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194037(5-4-2-chloro-4-fluorophenoxy)phenylamino)-3-hydrox...)
Affinity DataIC50:  85nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194027(5-3-chloro-4-2-chloro-4-fluorophenoxy)phenylamino)...)
Affinity DataIC50:  107nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194038(5-4-2-chloro-3-trifluoromethyl)phenoxy)phenylamino...)
Affinity DataIC50:  120nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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