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Found 984 with Last Name = 'bell' and Initial = 'rl'
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Chul

LigandPNGBDBM17290(E2-adenosine hybrid compound, 8 | EM-1745 | EM1745...)
Affinity DataKi:  3nM ΔG°:  -50.6kJ/molepH: 7.5 T: 2°CAssay Description:For steady-state kinetic study of hybrid inhibitors, a Fluorolog 3 instrument was used to monitor the fluorescent signal of NADPH formed during estra...More data for this Ligand-Target Pair
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Chul

LigandPNGBDBM17293(Compound 10 | MB-329-131A2 | [5-(6-amino-9H-purin-...)
Affinity DataKi:  2.50E+5nM ΔG°:  -21.4kJ/molepH: 7.5 T: 2°CAssay Description:For steady-state kinetic study of hybrid inhibitors, a Fluorolog 3 instrument was used to monitor the fluorescent signal of NADPH formed during estra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50100403(CHEMBL423296 | {3-[4-(4-Bromo-phenyl)-thiazol-2-yl...)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory concentration against human recombinant Prostaglandin G/H synthase 2 cloned and expressed in baculovirus (Sf9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50100395(CHEMBL28155 | [3-(4-Benzo[b]thiophen-3-yl-thiazol-...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against human recombinant Prostaglandin G/H synthase 2 cloned and expressed in baculovirus (Sf9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor [671-1210,L858R](Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27970(1-{4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohex...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50327950(CHEMBL1256435 | trans-N-(4-(4-amino-1-(4-(4-methyl...)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315895(CHEMBL1090357 | N-(3-(5-(2-(4-(2-(dimethylamino)et...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of ErbB2 by time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315905(CHEMBL1090350 | N-(3-(5-(2-(4-morpholinophenylamin...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of ErbB2 by time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315903(CHEMBL1093234 | N-(3-(5-(2-(phenylamino)pyrimidin-...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of ErbB2 by time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50100404((4-Chloro-phenyl)-[5-methoxy-2-methyl-3-(4-naphtha...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against human recombinant Prostaglandin G/H synthase 2 cloned and expressed in baculovirus (Sf9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50100401((4-Bromo-phenyl)-{3-[4-(4-chloro-phenyl)-thiazol-2...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against human recombinant Prostaglandin G/H synthase 2 cloned and expressed in baculovirus (Sf9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50100400((4-Bromo-phenyl)-{5-methoxy-2-methyl-3-[4-(4-nitro...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against human recombinant Prostaglandin G/H synthase 2 cloned and expressed in baculovirus (Sf9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50085160(CHEMBL32842 | L-674636 | {4-(4-Chloro-phenyl)-1-[4...)
Affinity DataIC50:  7nMAssay Description:Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50315897(2,6-difluoro-N-(3-(5-(2-(1,2,3,4-tetrahydroisoquin...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of ErbB2 by time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50327947(CHEMBL1256432 | trans-N-(4-(4-amino-1-(4-(4-methyl...)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50327948(CHEMBL1257998 | trans-N-(4-(4-amino-1-(4-(4-methyl...)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of ErbB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17617(5,6-disubstituted anthranilic acid sulfonamide, 9i...)
Affinity DataIC50:  8nMpH: 7.4 T: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50409117(CHEMBL2093045)
Affinity DataIC50:  8nMAssay Description:Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50052018(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(qui...)
Affinity DataIC50:  8nMAssay Description:Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50100396(CHEMBL24407 | {3-[4-(3-Bromo-phenyl)-thiazol-2-ylm...)
Affinity DataIC50:  8nMAssay Description:Inhibitory concentration against human recombinant Prostaglandin G/H synthase 2 cloned and expressed in baculovirus (Sf9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17573(2-({2-[(1Z)-3-[ethyl(methyl)amino]prop-1-en-1-yl]b...)
Affinity DataIC50:  9nMT: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17579(2-({2-[3-(diethylamino)propyl]benzene}sulfonamido)...)
Affinity DataIC50:  9nMT: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50085202(2-{4-(4-Fluoro-phenyl)-1-[4-(quinolin-2-ylmethoxy)...)
Affinity DataIC50:  9nMAssay Description:Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17478(2-benzenesulfonamido-5,6,7,8-tetrahydronaphthalene...)
Affinity DataIC50:  9nMpH: 7.4 T: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50327959(CHEMBL1256425 | trans-N-(4-(4-amino-1-(4-(4-isopro...)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of ErbB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17505(2-[(2-{[3-(1H-imidazol-1-yl)propyl]amino}benzene)s...)
Affinity DataIC50:  10nMT: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17564(2-({4-fluoro-2-[(1Z)-3-(pyrrolidin-1-yl)but-1-en-1...)
Affinity DataIC50:  10nMT: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17583(2-({2-[3-(dimethylamino)propyl]benzene}sulfonamido...)
Affinity DataIC50:  10nMT: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50085231(CHEMBL159297 | {2-Butyl-1-[4-(quinolin-2-ylmethoxy...)
Affinity DataIC50:  10nMAssay Description:Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17478(2-benzenesulfonamido-5,6,7,8-tetrahydronaphthalene...)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17630(5,6-disubstituted anthranilic acid sulfonamide, 19...)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50085229(CHEMBL159516 | {3-Methyl-3-phenyl-1-[4-(quinolin-2...)
Affinity DataIC50:  10nMAssay Description:Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17607(2-[(4-fluorobenzene)sulfonamido]-5,6,7,8-tetrahydr...)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17616(3-ethyl-6-[(4-fluorobenzene)sulfonamido]-2-methoxy...)
Affinity DataIC50:  11nMpH: 7.4 T: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17560(2-({2-[(1Z)-3-(diethylamino)prop-1-en-1-yl]-4-fluo...)
Affinity DataIC50:  11nMT: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17519(2-[(2-{[4-(dimethylamino)butyl]amino}benzene)sulfo...)
Affinity DataIC50:  12nMT: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17559(2-({2-[(1Z)-3-(diethylamino)prop-1-en-1-yl]benzene...)
Affinity DataIC50:  12nMT: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17575(2-({2-[(1Z)-3-[methyl(propan-2-yl)amino]prop-1-en-...)
Affinity DataIC50:  12nMT: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50100402((4-Chloro-phenyl)-{5-methoxy-2-methyl-3-[4-(4-nitr...)
Affinity DataIC50:  12nMAssay Description:Inhibitory concentration against human recombinant Prostaglandin G/H synthase 2 cloned and expressed in baculovirus (Sf9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17488(2-[(2-{[3-(ethylamino)propyl]amino}benzene)sulfona...)
Affinity DataIC50:  12nMpH: 7.4 T: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  12nMAssay Description:Inhibition activity against recombinant human Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50100399((4-Chloro-phenyl)-{3-[4-(4-fluoro-phenyl)-thiazol-...)
Affinity DataIC50:  12nMAssay Description:Inhibitory concentration against human recombinant Prostaglandin G/H synthase 2 cloned and expressed in baculovirus (Sf9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50327948(CHEMBL1257998 | trans-N-(4-(4-amino-1-(4-(4-methyl...)
Affinity DataIC50:  12.5nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17521(2-[(2-aminobenzene)sulfonamido]-5,6,7,8-tetrahydro...)
Affinity DataIC50:  13nMT: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17492(2-({2-[(3-aminopropyl)amino]benzene}sulfonamido)-5...)
Affinity DataIC50:  13nMpH: 7.4 T: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50085170(2-{Cycloheptyl-[4-(quinolin-2-ylmethoxy)-phenyl]-m...)
Affinity DataIC50:  13nMAssay Description:Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM27970(1-{4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohex...)
Affinity DataIC50:  13nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50327952(CHEMBL1256431 | N-(4-(4-amino-1-(1'-(3-methoxyprop...)
Affinity DataIC50:  13.8nMAssay Description:Inhibition of ErbB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17483(2-[(2-{[3-(dimethylamino)propyl]amino}benzene)sulf...)
Affinity DataIC50:  14nMpH: 7.4 T: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50100397((4-Chloro-phenyl)-{3-[4-(4-chloro-phenyl)-thiazol-...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration against human recombinant Prostaglandin G/H synthase 2 cloned and expressed in baculovirus (Sf9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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