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Found 4134 with Last Name = 'bruncko' and Initial = 'm'
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM189804(US10213433, Compound 378 | US11369599, Compound 37...)
Affinity DataKi: <0.00100nM ΔG°: <-68.5kJ/moleT: 2°CAssay Description:Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM189800(US10213433, Compound 374 | US11369599, Compound 37...)
Affinity DataKi: <0.00100nM ΔG°: <-68.5kJ/moleT: 2°CAssay Description:Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM144940(US8952157, 122 | US9303025, 122)
Affinity DataKi: <0.00100nM ΔG°: <-68.5kJ/moleT: 2°CAssay Description:Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 μM (2× starting concentration; 10% DMSO) and 10 μ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178562(US9125913, 121)
Affinity DataKi:  0.00100nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM189797(US11369599, Compound 376 | US9174982, 371 | US9174...)
Affinity DataKi: <0.00100nM ΔG°: <-68.5kJ/moleT: 2°CAssay Description:Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM189803(US11369599, Compound 377 | US9174982, 377)
Affinity DataKi: <0.00100nM ΔG°: <-68.5kJ/moleT: 2°CAssay Description:Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM189797(US11369599, Compound 376 | US9174982, 371 | US9174...)
Affinity DataKi: <0.00100nM ΔG°: <-68.5kJ/moleT: 2°CAssay Description:Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM189799(US10213433, Compound 373 | US11369599, Compound 37...)
Affinity DataKi: <0.00100nM ΔG°: <-68.5kJ/moleT: 2°CAssay Description:Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178836(US9125913, 408)
Affinity DataKi:  0.00200nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM189567(US10213433, Compound 129 | US11369599, Compound 12...)
Affinity DataKi:  0.00200nM ΔG°:  -66.8kJ/moleT: 2°CAssay Description:Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178843(US9125913, 415)
Affinity DataKi:  0.00200nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178855(US9125913, 427)
Affinity DataKi:  0.00200nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178853(US9125913, 425)
Affinity DataKi:  0.00300nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178839(US9125913, 411)
Affinity DataKi:  0.00300nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178831(US9125913, 403)
Affinity DataKi:  0.00300nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178566(US9125913, 125)
Affinity DataKi:  0.00300nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178856(US9125913, 428)
Affinity DataKi:  0.00300nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178883(US9125913, 455)
Affinity DataKi:  0.00400nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178846(US9125913, 418)
Affinity DataKi:  0.00400nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM145154(US8952157, 345 | US9303025, 345)
Affinity DataKi:  0.00500nM ΔG°:  -64.5kJ/moleT: 2°CAssay Description:Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 μM (2× starting concentration; 10% DMSO) and 10 μ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178876(US9125913, 448)
Affinity DataKi:  0.00500nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM144855(US8952157, 37 | US9303025, 37)
Affinity DataKi:  0.00500nM ΔG°:  -64.5kJ/moleT: 2°CAssay Description:Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 μM (2× starting concentration; 10% DMSO) and 10 μ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178639(US9125913, 205)
Affinity DataKi:  0.00500nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178793(US9125913, 364)
Affinity DataKi:  0.00600nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178842(US9125913, 414)
Affinity DataKi:  0.00700nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178891(US9125913, 463)
Affinity DataKi:  0.00700nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178854(US9125913, 426)
Affinity DataKi:  0.00700nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM209097(US9266877, 43)
Affinity DataKi:  0.00800nMAssay Description:Inhibition of F-Bak (GQVGRQLAIIGDK(6-FAM)INR-amide probe binding to BCL-xl (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178576(US9125913, 135)
Affinity DataKi:  0.00800nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178579(US9125913, 138)
Affinity DataKi:  0.00900nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM145152(US8952157, 343 | US9303025, 343)
Affinity DataKi:  0.00900nM ΔG°:  -63.0kJ/moleT: 2°CAssay Description:Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 μM (2× starting concentration; 10% DMSO) and 10 μ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178645(US9125913, 211)
Affinity DataKi:  0.00900nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178574(US9125913, 133)
Affinity DataKi:  0.00900nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM189485(US10213433, Compound 37 | US11369599, Compound 37 ...)
Affinity DataKi: <0.0100nM ΔG°: <-62.8kJ/moleT: 2°CAssay Description:Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM189488(US10213433, Compound 40 | US11369599, Compound 40 ...)
Affinity DataKi: <0.0100nM ΔG°: <-62.8kJ/moleT: 2°CAssay Description:Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM189489(US10213433, Compound 41 | US11369599, Compound 41 ...)
Affinity DataKi: <0.0100nM ΔG°: <-62.8kJ/moleT: 2°CAssay Description:Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM189492(US9174982, 44)
Affinity DataKi: <0.0100nM ΔG°: <-62.8kJ/moleT: 2°CAssay Description:Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM189493(US10213433, Compound 45 | US11369599, Compound 45 ...)
Affinity DataKi: <0.0100nM ΔG°: <-62.8kJ/moleT: 2°CAssay Description:Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178828(US9125913, 400)
Affinity DataKi: <0.0100nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178829(US9125913, 401)
Affinity DataKi: <0.0100nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178837(US9125913, 409)
Affinity DataKi: <0.0100nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178851(US9125913, 423)
Affinity DataKi: <0.0100nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178852(US9125913, 424)
Affinity DataKi: <0.0100nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178857(US9125913, 429)
Affinity DataKi: <0.0100nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178858(US9125913, 430)
Affinity DataKi: <0.0100nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178859(US9125913, 431)
Affinity DataKi: <0.0100nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178861(US9125913, 433)
Affinity DataKi: <0.0100nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178865(US9125913, 437)
Affinity DataKi: <0.0100nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178866(US9125913, 438)
Affinity DataKi: <0.0100nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Abbvie

US Patent
LigandPNGBDBM178867(US9125913, 439)
Affinity DataKi: <0.0100nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
In DepthDetails US Patent
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