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Found 414 with Last Name = 'ceska' and Initial = 't'
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Ucb

Curated by ChEMBL
LigandPNGBDBM50601136(CHEMBL5177437)
Affinity DataIC50:  0.251nMAssay Description:Inhibition of full-length N-terminal His-TEV-tagged inactive form of MSK1 (2 to 802 residues) (unknown origin) expressed in HEK293 cells using FAM-PS...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Ucb

Curated by ChEMBL
LigandPNGBDBM259876(US9505766, 81)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of N-terminal His-Smt-tagged MSK1 C-terminal kinase domain (414 to 738 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457851(CHEMBL4205416)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50271563(CHEMBL482708 | N-cyclohexyl-4-(H-imidazo[1,2-a]pyr...)
Affinity DataIC50:  3nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457853(CHEMBL4215340)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457851(CHEMBL4205416)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457886(CHEMBL4211696)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457855(CHEMBL4211181)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression systemMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457854(CHEMBL4206816)
Affinity DataIC50:  5nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211428(CHEMBL245936 | N-ethyl-4-(4-(2-phenyl-1H-indol-3-y...)
Affinity DataIC50:  5nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211428(CHEMBL245936 | N-ethyl-4-(4-(2-phenyl-1H-indol-3-y...)
Affinity DataIC50:  5nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Ucb

Curated by ChEMBL
LigandPNGBDBM259876(US9505766, 81)
Affinity DataIC50:  5nMAssay Description:Inhibition of full-length N-terminal His-TEV-tagged inactive form of MSK1 (2 to 802 residues) (unknown origin) expressed in HEK293 cells using FAM-PS...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457867(CHEMBL4203566)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457848(CHEMBL4215244)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50005005(CHEMBL2397317)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457850(CHEMBL4203041)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457876(CHEMBL4209793)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457868(CHEMBL4202450)
Affinity DataIC50:  8nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457853(CHEMBL4215340)
Affinity DataIC50:  8nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457860(CHEMBL4207851)
Affinity DataIC50:  9nMAssay Description:GRAC: human Y1 selective antagonistMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457870(CHEMBL1652677)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Ucb

Curated by ChEMBL
LigandPNGBDBM50601139(CHEMBL5190298)
Affinity DataIC50:  10nMAssay Description:Inhibition of full-length N-terminal His-TEV-tagged inactive form of MSK1 (2 to 802 residues) (unknown origin) expressed in HEK293 cells using FAM-PS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457871(CHEMBL4210308)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457855(CHEMBL4211181)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457848(CHEMBL4215244)
Affinity DataIC50:  13nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211424(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211436(2-(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamin...)
Affinity DataIC50:  13nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Ucb

Curated by ChEMBL
LigandPNGBDBM50601138(CHEMBL5184056)
Affinity DataIC50:  13nMAssay Description:Inhibition of full-length N-terminal His-TEV-tagged inactive form of MSK1 (2 to 802 residues) (unknown origin) expressed in HEK293 cells using FAM-PS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211436(2-(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamin...)
Affinity DataIC50:  14nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211430((4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)...)
Affinity DataIC50:  14nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211438(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211426(2-((R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl...)
Affinity DataIC50:  15nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211443((3S)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylam...)
Affinity DataIC50:  15nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211430((4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)...)
Affinity DataIC50:  15nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457870(CHEMBL1652677)
Affinity DataIC50:  16nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50262173(2-(6-(1H-pyrazol-4-yl)-2,3-dihydrobenzo[b][1,4]oxa...)
Affinity DataIC50:  16nMAssay Description:Inhibition of PI3K delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262174(2-(6-(1H-pyrazol-4-yl)-2,3-dihydrobenzo[b][1,4]oxa...)
Affinity DataIC50:  17nMAssay Description:Inhibition of PI3K delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457886(CHEMBL4211696)
Affinity DataIC50:  18nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457862(CHEMBL4204100)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211429((4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)...)
Affinity DataIC50:  18nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataIC50:  19nMAssay Description:Inhibition of PI4K3beta (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457854(CHEMBL4206816)
Affinity DataIC50:  19nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Ucb

Curated by ChEMBL
LigandPNGBDBM50601140(CHEMBL5183170)
Affinity DataIC50:  20nMAssay Description:Inhibition of full-length N-terminal His-TEV-tagged inactive form of MSK1 (2 to 802 residues) (unknown origin) expressed in HEK293 cells using FAM-PS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Ucb

Curated by ChEMBL
LigandPNGBDBM50601158(CHEMBL5186781)
Affinity DataIC50:  20nMAssay Description:Inhibition of full-length N-terminal His-TEV-tagged inactive form of MSK1 (2 to 802 residues) (unknown origin) expressed in HEK293 cells using FAM-PS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457866(CHEMBL4207928)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50261783(5,5-dimethyl-2-(6-(pyridin-3-yl)-2,3-dihydrobenzo[...)
Affinity DataIC50:  20nMAssay Description:Inhibition of PI3K delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-4(Homo sapiens (Human))
Ucb

Curated by ChEMBL
LigandPNGBDBM50601138(CHEMBL5184056)
Affinity DataIC50:  20nMAssay Description:Inhibition of MSK2 (unknown origin) FAM-PSKPAATRKRRWSAPESR-NH2 as substrate preincubated for 1 hr followed by activation with ERK2 and substrate addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
LigandPNGBDBM50261838(6,6-dimethyl-2-(6-(6-methylpyridin-3-yl)-2,3-dihyd...)
Affinity DataIC50:  21nMAssay Description:Inhibition of PI3K delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211428(CHEMBL245936 | N-ethyl-4-(4-(2-phenyl-1H-indol-3-y...)
Affinity DataIC50:  22nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262173(2-(6-(1H-pyrazol-4-yl)-2,3-dihydrobenzo[b][1,4]oxa...)
Affinity DataIC50:  22nMAssay Description:Inhibition of PI3K gamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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