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Found 2401 with Last Name = 'chao' and Initial = 'ys'
TargetAurora kinase A(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of Aurora A kinaseMore data for this Ligand-Target Pair
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50326392((2S)-1-({(2S,4S)-4-[2-(1,3-Dihydro-2H-isoindol-2-y...)
Affinity DataKi:  1.30nMAssay Description:Competitive inhibition of human recombinant FAP expressed in Hi5 insect cells by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of Aurora B kinaseMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50000788((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-naloxone from rat mu opioid receptor expressed in HEK cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  4.60nMAssay Description:Inhibition of Aurora C kinaseMore data for this Ligand-Target Pair
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50326373((R)-1-(2-(1-naphthamido)acetyl)pyrrolidin-2-ylboro...)
Affinity DataKi:  7.90nMAssay Description:Competitive inhibition of human recombinant FAP expressed in Hi5 insect cells by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM12985(5-Amido-pyrrolopyrazole 9d | CHEMBL402548 | N-{5-[...)
Affinity DataKi:  13nMAssay Description:Inhibition of Aurora A kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM12985(5-Amido-pyrrolopyrazole 9d | CHEMBL402548 | N-{5-[...)
Affinity DataKi:  61nMAssay Description:Inhibition of Aurora C kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM12985(5-Amido-pyrrolopyrazole 9d | CHEMBL402548 | N-{5-[...)
Affinity DataKi:  79nMAssay Description:Inhibition of Aurora B kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50055967(CHEMBL3325714)
Affinity DataKi:  470nMAssay Description:Displacement of [3H]-naloxone from rat mu opioid receptor expressed in HEK cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50055966(CHEMBL3325715)
Affinity DataKi:  610nMAssay Description:Displacement of [3H]-naloxone from rat mu opioid receptor expressed in HEK cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50055965(CHEMBL3325716)
Affinity DataKi:  740nMAssay Description:Displacement of [3H]-naloxone from rat mu opioid receptor expressed in HEK cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50055969(CHEMBL3325719)
Affinity DataKi:  1.30E+3nMAssay Description:Displacement of [3H]-naloxone from rat mu opioid receptor expressed in HEK cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50055973(CHEMBL3325707)
Affinity DataKi:  3.93E+3nMAssay Description:Displacement of [3H]-naloxone from rat mu opioid receptor expressed in HEK cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM21973(1-Methyltryptophan, 1 | 2-amino-3-(1-methyl-1H-ind...)
Affinity DataKi:  3.40E+4nMAssay Description:Inhibition of human recombinant IDO using L-tryptophan as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50055972(CHEMBL3325710)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]-naloxone from rat mu opioid receptor expressed in HEK cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50055964(CHEMBL3325841)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]-naloxone from rat mu opioid receptor expressed in HEK cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataIC50:  0.300nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP production after 30 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50001683(13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Affinity DataIC50:  0.900nMAssay Description:Agonist activity at human delta opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP production after 30 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167697((4aR,9S)-6-Hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10,1...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-beta in SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167698(13-hydroxy-2,6-dimethyl-(2S,7R)-tricyclo[8.4.0.02,...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-beta in SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50389234(CHEMBL2063324)
Affinity DataIC50:  1nMAssay Description:Inhibition of FLT3 autophosphorylation in human MV4-11 cells after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167697((4aR,9S)-6-Hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10,1...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-alpha in SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50253758(1-(2,4-Dichlorophenyl)-4-methyl-5-(5-(pent-1-ynyl)...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50253843(1-(2,4-Dichlorophenyl)-4-ethyl-5-(5-(pent-1-ynyl)t...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50253807(CHEMBL462686 | N-(Azepan-1-yl)-1-(2,4-dichlorophen...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50253844(CHEMBL460987 | N-(Azepan-1-yl)-1-(2,4-dichlorophen...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50253806(1-(2,4-Dichlorophenyl)-4-methyl-5-(5-(4-methylpent...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50253805(CHEMBL460132 | N-(Azepan-1-yl)-1-(2,4-dichlorophen...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50253918(1-(2,4-Dichlorophenyl)-5-(5-(hex-1-ynyl)thiophen-2...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50253917(1-(2,4-Dichlorophenyl)-5-(5-(hex-1-ynyl)thiophen-2...)
Affinity DataIC50:  1.40nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50253298(CHEMBL522522 | N-(Azepan-1-yl)-1-(2,4-dichlorophen...)
Affinity DataIC50:  1.70nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM12178((2S)-1-{[(2S,4S)-4-(2,3-dihydro-1H-isoindol-2-ylca...)
Affinity DataIC50:  1.70nMpH: 8.0 T: 2°CAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167694(2,6-dimethyl-13-methylcarbonyloxy-(2S)-tricyclo[8....)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-beta in SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167694(2,6-dimethyl-13-methylcarbonyloxy-(2S)-tricyclo[8....)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-alpha in SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167698(13-hydroxy-2,6-dimethyl-(2S,7R)-tricyclo[8.4.0.02,...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-alpha in SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM50257317((S)-1-((S)-2-amino-5-(isoindolin-2-yl)-5-oxopentan...)
Affinity DataIC50:  2nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50434621(CHEMBL2386796)
Affinity DataIC50:  2nMAssay Description:Inhibition of wild type GST tagged FLT3 kinase (567 to 993) (unknown origin) transfected in insect sf9 cells after 4 hrs by wallac counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50253300(CHEMBL494300 | N-Cyclohexyl-1-(2,4-dichlorophenyl)...)
Affinity DataIC50:  2.10nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50253806(1-(2,4-Dichlorophenyl)-4-methyl-5-(5-(4-methylpent...)
Affinity DataIC50:  2.30nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM50265158(CHEMBL497992 | N-((trans)-4-((S)-1-amino-2-oxo-2-(...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human DPP4 expressed in baculovirus systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50253299(1-(2,4-Dichlorophenyl)-5-(5-(hex-1-ynyl)thiophen-2...)
Affinity DataIC50:  2.60nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50253757(CHEMBL462069 | N-Butyl-1-(2,4-dichlorophenyl)-5-(5...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant GST-tagged VEGFR2 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50389222(CHEMBL2063336)
Affinity DataIC50:  4nMAssay Description:Inhibition of wild type FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50434614(CHEMBL2386803)
Affinity DataIC50:  4nMAssay Description:Inhibition of wild type GST tagged FLT3 kinase (567 to 993) (unknown origin) transfected in insect sf9 cells after 4 hrs by wallac counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50253807(CHEMBL462686 | N-(Azepan-1-yl)-1-(2,4-dichlorophen...)
Affinity DataIC50:  4.90nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM50320120((2S,4S)-4-fluoro-1-(2-(2-methyl-4-oxo-4-(pyrrolidi...)
Affinity DataIC50:  5nMAssay Description:Inhibition of DPP4 in presence of 50% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataIC50:  5nMAssay Description:Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP production after 30 mins by H...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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