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Found 1453 with Last Name = 'chapman' and Initial = 'kt'
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289127((2S,4R)-4-(3-Methyl-1-phenylcarbamoyl-butylcarbamo...)
Affinity DataKi:  0.360nMAssay Description:Inhibition of matrix metalloproteinase-3(MMP-3).More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM10355((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataKi:  0.760nMAssay Description:The compound was tested for inhibition of IL-1 beta converting enzyme in whole human blood.More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289128((R)-6-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-[(S)...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of matrix metalloproteinase-3(MMP-3).More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057073((2S,4R)-6-(4'-Fluoro-biphenyl-4-yl)-4-((S)-3-methy...)
Affinity DataKi:  2nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057050((2S,4R)-2-Butyl-4-[(S)-2,2-dimethyl-1-(pyridin-4-y...)
Affinity DataKi:  2nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285557((R)-2-[(S)-3-(4-butyl-phenyl)-1-((S)-4-guanidino-1...)
Affinity DataKi:  2.10nMAssay Description:Inhibitory activity against human gelatinase-A (MMP-2)More data for this Ligand-Target Pair
In DepthDetails Article
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289128((R)-6-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-[(S)...)
Affinity DataKi:  2.60nMAssay Description:Inhibition of matrix metalloproteinase-2(MMP-2)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282978(3-{(S)-2-[(S)-3-Methyl-2-(3-phenyl-propionylamino)...)
Affinity DataKi:  2.70nMAssay Description:Tested for inhibition of cysteine proteinase IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285567((R)-2-[(S)-1-((S)-4-guanidino-1-phenylcarbamoyl-bu...)
Affinity DataKi:  3nMAssay Description:Inhibitory activity against human gelatinase-A (MMP-2)More data for this Ligand-Target Pair
In DepthDetails Article
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057090((R)-2-((S)-1-((S)-4-methyl-1-oxo-1-(phenylamino)pe...)
Affinity DataKi:  3.5nMAssay Description:Inhibitory activity against human gelatinase-A (MMP-2)More data for this Ligand-Target Pair
In DepthDetails Article
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057090((R)-2-((S)-1-((S)-4-methyl-1-oxo-1-(phenylamino)pe...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of matrix metalloproteinase-2(MMP-2)More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057063((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-phenylcarbam...)
Affinity DataKi:  4nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282981(3-{(S)-2-[(S)-3-Methyl-2-(3-phenyl-propionylamino)...)
Affinity DataKi:  4.70nMAssay Description:Tested for inhibition of cysteine proteinase IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057041((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  5nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50040594((R)-4-(1,3-Dioxo-1,3-dihydro-benzo[f]isoindol-2-yl...)
Affinity DataKi:  5nMAssay Description:Inhibition of matrix metalloproteinase -1More data for this Ligand-Target Pair
In DepthDetails Article
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289127((2S,4R)-4-(3-Methyl-1-phenylcarbamoyl-butylcarbamo...)
Affinity DataKi:  5.70nMAssay Description:Inhibition of matrix metalloproteinase-2(MMP-2)More data for this Ligand-Target Pair
In DepthDetails Article
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285573((R)-2-[(S)-3-(4-ethoxy-phenyl)-1-((S)-4-guanidino-...)
Affinity DataKi:  6.10nMAssay Description:Inhibitory activity against human gelatinase-A (MMP-2)More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50043582(1N-phenyl-2-[1-[1-amino-(1R)-ethylcarboxamido]-3-p...)
Affinity DataKi:  6.5nMAssay Description:Inhibition of rabbit fibroblast stromelysinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116264((S)-3-({(S)-(S)-5-[(S)-2-((S)-Acetyl-methyl-amino)...)
Affinity DataKi:  7nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116262((2S,5S)-5-[(S)-2-(2-Benzo[b]thiophen-3-yl-acetylam...)
Affinity DataKi:  7nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116260((R)-2-({(2S,5S)-5-[(S)-2-(Acetyl-methyl-amino)-3-(...)
Affinity DataKi:  8nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288702((R)-6-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-[(S)...)
Affinity DataKi:  8nMAssay Description:Inhibition of matrix metalloproteinase-3(MMP-3).More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288702((R)-6-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-[(S)...)
Affinity DataKi:  8nMAssay Description:Inhibition of MMP-3.More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057061((2S,4R)-2-Butyl-6-(4'-cyano-biphenyl-4-yl)-4-((S)-...)
Affinity DataKi:  9nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288710((R)-2-[(S)-1-((S)-3-Methyl-1-phenylcarbamoyl-butyl...)
Affinity DataKi:  9.5nMAssay Description:Inhibition of MMP-3.More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289123((R)-2-[(S)-1-(3-Methyl-1-phenylcarbamoyl-butylcarb...)
Affinity DataKi:  9.5nMAssay Description:Inhibition of matrix metalloproteinase-3(MMP-3).More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057074((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  10nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057046((2S,4R)-2-Butyl-6-(2'-tert-butylsulfamoyl-biphenyl...)
Affinity DataKi:  10nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288705((R)-2-[(S)-1-((S)-3-Methyl-1-phenylcarbamoyl-butyl...)
Affinity DataKi:  10nMAssay Description:Inhibition of MMP-3.More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057039((2S,4R)-6-(4'-Bromo-biphenyl-4-yl)-2-butyl-4-((S)-...)
Affinity DataKi:  11nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285559((R)-2-((S)-4-(4-isobutylphenyl)-1-((S)-4-methyl-1-...)
Affinity DataKi:  11nMAssay Description:Inhibitory activity against human gelatinase-A (MMP-2)More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057062((2S,4R)-2-Butyl-4-[(S)-2,2-dimethyl-1-(pyridin-4-y...)
Affinity DataKi:  11nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282984(3-{(S)-2-[(S)-3-Methyl-2-(3-phenyl-propionylamino)...)
Affinity DataKi:  11nMAssay Description:Tested for inhibition of cysteine proteinase IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057088((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  11nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285564((R)-2-((S)-4-(4-ethylphenyl)-1-((S)-4-methyl-1-oxo...)
Affinity DataKi:  12nMAssay Description:Inhibitory activity against human gelatinase-A (MMP-2)More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057054((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  12nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288708((R)-2-[(S)-1-((S)-3-Methyl-1-phenylcarbamoyl-butyl...)
Affinity DataKi:  12nMAssay Description:Inhibition of MMP-3.More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057076((2S,4R)-2-Butyl-6-(2',4'-dichloro-biphenyl-4-yl)-4...)
Affinity DataKi:  12nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116255((2S,5S)-5-((S)-3-(S)-Methyl-2-phenylacetylamino-pe...)
Affinity DataKi:  13nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057079((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  13nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057075((2S,4R)-2-Butyl-6-(4'-chloro-biphenyl-4-yl)-4-((S)...)
Affinity DataKi:  13nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057041((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  13nMAssay Description:Inhibition of gelatinase A (Matrix metalloproteinase-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116256((S)-3-({1-[(S)-2-((3S,4S)-2-Acetylamino-3-methyl-p...)
Affinity DataKi:  13nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057061((2S,4R)-2-Butyl-6-(4'-cyano-biphenyl-4-yl)-4-((S)-...)
Affinity DataKi:  14nMAssay Description:Inhibition of gelatinase A (Matrix metalloproteinase-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057067((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  15nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057081((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  15nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057067((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  16nMAssay Description:Inhibition of gelatinase A (Matrix metalloproteinase-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057052((2S,4R)-6-(4-Benzyl-phenyl)-2-butyl-4-((S)-2,2-dim...)
Affinity DataKi:  16nMAssay Description:Inhibition of gelatinase A (Matrix metalloproteinase-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116267((S)-3-({(S)-(S)-5-[(S)-2-((S)-Acetyl-methyl-amino)...)
Affinity DataKi:  16nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057039((2S,4R)-6-(4'-Bromo-biphenyl-4-yl)-2-butyl-4-((S)-...)
Affinity DataKi:  17nMAssay Description:Inhibition of gelatinase A (Matrix metalloproteinase-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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