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Found 256 with Last Name = 'chapman' and Initial = 's'
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity against Retinoic acid receptor gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetRetinoic acid receptor gamma(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50092055((2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-cycl...)
Affinity DataKi: >400nMAssay Description:Binding affinity against Retinoic acid receptor gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50100957((3E,5E,7E,9E)-1-(4-Hydroxy-phenyl)-4,8-dimethyl-10...)
Affinity DataKi: >4.00E+3nMAssay Description:Binding affinity against Retinoic acid receptor gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50029174(CHEMBL131973 | N-(1-methylethyl)-3-[(3-prop-2-en-1...)
Affinity DataIC50:  0.00400nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50029177(CHEMBL134337 | Propionic acid 3-allyl-4-(3-isoprop...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50029166(Acetaldehyde O-[3-allyl-4-(3-isopropylamino-propox...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Rattus norvegicus (rat))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385398(CHEMBL2036730)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of rat DGAT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385398(CHEMBL2036730)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of DGAT1-mediated triacylglycerol synthesis in human HuTu80 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50029159(CHEMBL132881 | [3-(2-Allyl-4-butoxy-phenoxy)-propy...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385398(CHEMBL2036730)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human recombinant DGAT1 expressed in baculovirus infected insect sf9 cells using [14C] oleoyl coenzyme A after 30 mins by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50029171(CHEMBL341371 | N-[3-Benzyl-4-(3-isopropylamino-pro...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50116610(CHEMBL119743 | N-(9-Isopropyl-9H-carbazol-3-yl)-3-...)
Affinity DataIC50:  1nMAssay Description:Binding affinity to the human Neuropeptide Y receptor Y5 (NPY5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50116590(CHEMBL325486 | N-(9-Methanesulfonyl-9H-carbazol-3-...)
Affinity DataIC50:  1nMAssay Description:Binding affinity to the human Neuropeptide Y receptor Y5 (NPY5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50029179(1-[3-Allyl-4-(3-isopropylamino-propoxy)-phenyl]-bu...)
Affinity DataIC50:  1nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385398(CHEMBL2036730)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of mouse DGAT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50116619(CHEMBL117563 | Morpholine-4-carboxylic acid (9-iso...)
Affinity DataIC50:  2nMAssay Description:Binding affinity to the human Neuropeptide Y receptor Y5 (NPY5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50116602(CHEMBL419951 | Morpholine-4-carboxylic acid (9-iso...)
Affinity DataIC50:  2nMAssay Description:Binding affinity to the human Neuropeptide Y receptor Y5 (NPY5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50116600(CHEMBL325475 | N-(9-Ethyl-9H-carbazol-3-yl)-3-pyri...)
Affinity DataIC50:  2nMAssay Description:Binding affinity to the human Neuropeptide Y receptor Y5 (NPY5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50116605(CHEMBL432628 | Morpholine-4-carboxylic acid (6-flu...)
Affinity DataIC50:  3nMAssay Description:Binding affinity to the human Neuropeptide Y receptor Y5 (NPY5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50116617(CHEMBL116210 | N-(9-Acetyl-9H-carbazol-3-yl)-3-pyr...)
Affinity DataIC50:  3nMAssay Description:Binding affinity to the human Neuropeptide Y receptor Y5 (NPY5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50029163(CHEMBL340992 | Propionic acid 4-(3-isopropylamino-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50116592(CHEMBL325226 | Morpholine-4-carboxylic acid (9-iso...)
Affinity DataIC50:  3nMAssay Description:Binding affinity to the human Neuropeptide Y receptor Y5 (NPY5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385439(CHEMBL2036745)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of human recombinant DGAT1 expressed in baculovirus infected insect sf9 cells using [14C] oleoyl coenzyme A after 30 mins by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50029170(1-[3-Allyl-4-(2-hydroxy-3-isopropylamino-propoxy)-...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50029161(CHEMBL433864 | N-{3-Allyl-4-[3-(isopropyl-methyl-a...)
Affinity DataIC50:  5nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385429(CHEMBL2036734)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of human recombinant DGAT1 expressed in baculovirus infected insect sf9 cells using [14C] oleoyl coenzyme A after 30 mins by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50116592(CHEMBL325226 | Morpholine-4-carboxylic acid (9-iso...)
Affinity DataIC50:  6nMAssay Description:Compound was evaluated for functional antagonism of Neuropeptide Y receptor Y5 activity in cellular Ca fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385424(CHEMBL2036596)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of human recombinant DGAT1 expressed in baculovirus infected insect sf9 cells using [14C] oleoyl coenzyme A after 30 mins by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385412(CHEMBL2036583)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of human recombinant DGAT1 expressed in baculovirus infected insect sf9 cells using [14C] oleoyl coenzyme A after 30 mins by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50116597(CHEMBL119247 | Morpholine-4-carboxylic acid (9-eth...)
Affinity DataIC50:  7nMAssay Description:Binding affinity to the human Neuropeptide Y receptor Y5 (NPY5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Rat 6B)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50116600(CHEMBL325475 | N-(9-Ethyl-9H-carbazol-3-yl)-3-pyri...)
Affinity DataIC50:  7nMAssay Description:Binding affinity against rat Neuropeptide Y receptor Y5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50116608(CHEMBL117922 | N-(9-Dimethylsulfamoyl-9H-carbazol-...)
Affinity DataIC50:  8nMAssay Description:Binding affinity to the human Neuropeptide Y receptor Y5 (NPY5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605601(CHEMBL5184138)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605598(CHEMBL5188193)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605597(CHEMBL5204161)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50116600(CHEMBL325475 | N-(9-Ethyl-9H-carbazol-3-yl)-3-pyri...)
Affinity DataIC50:  11nMAssay Description:Compound was evaluated in vitro for human Neuropeptide Y receptor Y5 functional antagonism (reporter gene assay)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605555(CHEMBL5173250)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50029172(CHEMBL131930 | [3-(2-Benzyl-phenoxy)-propyl]-isopr...)
Affinity DataIC50:  12nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50116607(CHEMBL325639 | Morpholine-4-carboxylic acid (2,4-d...)
Affinity DataIC50:  12nMAssay Description:Binding affinity to the human Neuropeptide Y receptor Y5 (NPY5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385425(CHEMBL2036597)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant DGAT1 expressed in baculovirus infected insect sf9 cells using [14C] oleoyl coenzyme A after 30 mins by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605593(CHEMBL5179642)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50116603(CHEMBL443809 | Morpholine-4-carboxylic acid (9-met...)
Affinity DataIC50:  15nMAssay Description:Binding affinity to the human Neuropeptide Y receptor Y5 (NPY5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385415(CHEMBL2036586)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant DGAT1 expressed in baculovirus infected insect sf9 cells using [14C] oleoyl coenzyme A after 30 mins by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM210802(US10463663, Example 40 | US11129828, Example 40 | ...)
Affinity DataIC50:  17nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605594(CHEMBL5186374)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605599(CHEMBL5178413)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605592(CHEMBL5179643)
Affinity DataIC50:  21nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50385403(CHEMBL2036574)
Affinity DataIC50:  23nMAssay Description:Inhibition of human recombinant DGAT1 expressed in baculovirus infected insect sf9 cells using [14C] oleoyl coenzyme A after 30 mins by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605595(CHEMBL5174518)
Affinity DataIC50:  25nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605589(CHEMBL5196542)
Affinity DataIC50:  25nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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