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Found 1082 with Last Name = 'chen' and Initial = 'jm'
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi:  250nMAssay Description:Inhibition of human norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi:  1.35E+3nMAssay Description:Inhibition of human MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi:  7.73E+3nMAssay Description:Inhibition of human MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-15(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP15More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-20(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP20More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-24(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP24More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-25(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-26(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP26More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-16(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP16More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50118985(1-(Biphenyl-4-carbonyl)-4-(4-methoxy-benzenesulfon...)
Affinity DataIC50:  0.400nMAssay Description:Concentration of the compound required in vitro to inhibit Matrix metalloproteinase-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50118983(1-Benzoyl-4-(4-methoxy-benzenesulfonyl)-2,3,4,5-te...)
Affinity DataIC50:  0.400nMAssay Description:Concentration of the compound required in vitro to inhibit Matrix metalloproteinase-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50106133(5-Bromo-2-{[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Affinity DataIC50:  0.5nMAssay Description:In vitro inhibition of Matrix metalloprotease-9.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395921(CHEMBL2164511)
Affinity DataIC50:  0.511nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485077(CHEMBL2023517)
Affinity DataIC50:  0.520nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC expressed in Escherichia coli using UDP-3-O-N-acetylglucosamine substrate measured after 30 mins by mass sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485061(CHEMBL2023524)
Affinity DataIC50:  0.530nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC expressed in Escherichia coli using UDP-3-O-N-acetylglucosamine substrate measured after 30 mins by mass sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50118983(1-Benzoyl-4-(4-methoxy-benzenesulfonyl)-2,3,4,5-te...)
Affinity DataIC50:  0.600nMAssay Description:Concentration required in vitro to inhibit Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395911(CHEMBL2164521)
Affinity DataIC50:  0.657nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50118985(1-(Biphenyl-4-carbonyl)-4-(4-methoxy-benzenesulfon...)
Affinity DataIC50:  0.700nMAssay Description:Concentration required in vitro to inhibit Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50106133(5-Bromo-2-{[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of Matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50106136(2-{[4-(4-Chloro-phenoxy)-benzenesulfonyl]-methyl-a...)
Affinity DataIC50:  0.800nMAssay Description:In vitro inhibition of Matrix metalloprotease-13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395920(CHEMBL2164512)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395910(CHEMBL2164522)
Affinity DataIC50:  0.912nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50508758(CHEMBL4460909 | US11312713, Example 82)
Affinity DataIC50:  0.938nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50126612(4-{[4-(4-Chloro-phenoxy)-benzenesulfonyl]-methyl-a...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against matrix metalloproteinase 9 (MMP-9).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50118975(4-(4-Methoxy-benzenesulfonyl)-1-(thiophene-2-carbo...)
Affinity DataIC50:  1nMAssay Description:Concentration required in vitro to inhibit Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485056(CHEMBL2023515)
Affinity DataIC50:  1nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC expressed in Escherichia coli using UDP-3-O-N-acetylglucosamine substrate measured after 30 mins by mass sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50118975(4-(4-Methoxy-benzenesulfonyl)-1-(thiophene-2-carbo...)
Affinity DataIC50:  1nMAssay Description:Concentration of the compound required in vitro to inhibit Matrix metalloproteinase-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50126626(4-{Methyl-[4-(pyridin-4-yloxy)-benzenesulfonyl]-am...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against matrix metalloproteinase 9 (MMP-9).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50106130(CHEMBL100512 | N-Hydroxy-2-[(4-methoxy-benzenesulf...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of Matrix metalloprotease-9.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50106136(2-{[4-(4-Chloro-phenoxy)-benzenesulfonyl]-methyl-a...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of Matrix metalloprotease-9.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181002((S)-N-hydroxy-2,2-dimethyl-4-(4-(prop-2-ynyloxy)ph...)
Affinity DataIC50:  1nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181006((S)-4-(4-(but-3-ynyloxy)phenylsulfonyl)-N-hydroxy-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181002((S)-N-hydroxy-2,2-dimethyl-4-(4-(prop-2-ynyloxy)ph...)
Affinity DataIC50:  1nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50126623(8-Methoxy-4-[(4-methoxy-benzenesulfonyl)-pyridin-3...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against matrix metalloproteinase 13 (MMP-13).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50126626(4-{Methyl-[4-(pyridin-4-yloxy)-benzenesulfonyl]-am...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against matrix metalloproteinase 13 (MMP-13).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50126622(4-(N-benzyl-4-methoxyphenylsulfonamido)-N-hydroxy-...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against matrix metalloproteinase 13 (MMP-13).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50126612(4-{[4-(4-Chloro-phenoxy)-benzenesulfonyl]-methyl-a...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against matrix metalloproteinase 13 (MMP-13).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50126600(1,3-Dimethyl-4-{methyl-[4-(pyridin-4-yloxy)-benzen...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against matrix metalloproteinase 13 (MMP-13).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50126624(8-Bromo-4-[(4-methoxy-benzenesulfonyl)-pyridin-3-y...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against matrix metalloproteinase 13 (MMP-13).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50126620(4-[(4-Methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against matrix metalloproteinase 13 (MMP-13).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50118974(1-Acetyl-4-(4-methoxy-benzenesulfonyl)-2,3,4,5-tet...)
Affinity DataIC50:  1nMAssay Description:Concentration of the compound required in vitro to inhibit Matrix metalloproteinase-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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