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Found 76 with Last Name = 'cihlar' and Initial = 't'
TargetSolute carrier family 22 member 6(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50206509(4-Dipropylsulfamoyl-benzoic acid | 4-Dipropylsulfa...)
Affinity DataKi:  4.30E+3nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataIC50:  19nMAssay Description:Inhibition of HSP90 (unknown origin)More data for this Ligand-Target Pair
TargetLiver carboxylesterase(Sus scrofa)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50022772(CHEMBL1025 | Diisopropoxyphosphoryl fluoride | Dii...)
Affinity DataIC50:  50nMAssay Description:Inhibition of porcine liver carboxylesterase using [14C]GS7340 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Science

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50:  50nMAssay Description:Inhibition on HIV1 reverse transcriptase p66/p51More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Science

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50:  50nMAssay Description:Inhibition of wild type HIV 3B reverse transcriptase in MT2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Science

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50:  50nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50350205(CHEMBL1814774)
Affinity DataIC50:  50nMAssay Description:Inhibition of human ADK using [3H]-adenosine by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Science

Curated by ChEMBL
LigandPNGBDBM50013111(1-((2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl...)
Affinity DataIC50:  60nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Science

Curated by ChEMBL
LigandPNGBDBM50018445(1-((2R,5S)-5-(hydroxymethyl)-tetrahydrofuran-2-yl)...)
Affinity DataIC50:  120nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Science

Curated by ChEMBL
LigandPNGBDBM50479807(CHEMBL525256)
Affinity DataIC50:  130nMAssay Description:Inhibition on HIV1 reverse transcriptase p66/p51More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Science

Curated by ChEMBL
LigandPNGBDBM50366816(ABACAVIR | Epzicom | Ziagen)
Affinity DataIC50:  130nMAssay Description:Inhibition on HIV1 reverse transcriptase p66/p51More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50350207(CHEMBL1814776)
Affinity DataIC50:  200nMAssay Description:Inhibition of human ADK using [3H]-adenosine by scintillation countingMore data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50571534(CHEMBL3120779)
Affinity DataIC50:  370nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase using sshRNA template preincubated for 5 mins followed by compound addition and measured after 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Science

Curated by ChEMBL
LigandPNGBDBM50450813(Atripla | CHEBI:63625 | GS-1275 | PMP-A | Tenofovi...)
Affinity DataIC50:  380nMAssay Description:Inhibition on HIV1 reverse transcriptase p66/p51More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Science

Curated by ChEMBL
LigandPNGBDBM50450813(Atripla | CHEBI:63625 | GS-1275 | PMP-A | Tenofovi...)
Affinity DataIC50:  380nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Science

Curated by ChEMBL
LigandPNGBDBM50450813(Atripla | CHEBI:63625 | GS-1275 | PMP-A | Tenofovi...)
Affinity DataIC50:  380nMAssay Description:Inhibition of wild type HIV 3B reverse transcriptase in MT2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Science

Curated by ChEMBL
LigandPNGBDBM50370655(CHEMBL485652)
Affinity DataIC50:  390nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Science

Curated by ChEMBL
LigandPNGBDBM50476386(CHEMBL122885)
Affinity DataIC50:  390nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Science

Curated by ChEMBL
LigandPNGBDBM50478099(CHEMBL271681)
Affinity DataIC50:  400nMAssay Description:Inhibition of wild type HIV 3B reverse transcriptase in MT2 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Science

Curated by ChEMBL
LigandPNGBDBM50478098(CHEMBL420843)
Affinity DataIC50:  600nMAssay Description:Inhibition on HIV1 reverse transcriptase p66/p51More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Science

Curated by ChEMBL
LigandPNGBDBM50478098(CHEMBL420843)
Affinity DataIC50:  600nMAssay Description:Inhibition of wild type HIV 3B reverse transcriptase in MT2 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysosomal protective protein(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50199883(3,4‐Dichloroisocoumarin (2) | 3,4-Dichloro-i...)
Affinity DataIC50:  600nMAssay Description:Inhibition of recombinant CatA using [14C]GS7340 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Science

Curated by ChEMBL
LigandPNGBDBM50479808(CHEMBL512522)
Affinity DataIC50:  620nMAssay Description:Inhibition on HIV1 reverse transcriptase p66/p51More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 6(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataIC50:  850nMAssay Description:TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetSolute carrier family 22 member 6(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50022271(2-(3-Benzoylphenyl)propionic acid | 2-(3-benzoylph...)
Affinity DataIC50:  1.30E+3nMAssay Description:TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetSolute carrier family 22 member 6(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50022271(2-(3-Benzoylphenyl)propionic acid | 2-(3-benzoylph...)
Affinity DataIC50:  1.40E+3nMAssay Description:TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSolute carrier family 22 member 6(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50074922((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)
Affinity DataIC50:  1.50E+3nMAssay Description:TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Science

Curated by ChEMBL
LigandPNGBDBM50478100(CHEMBL252036 | GS-9148)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition on HIV1 reverse transcriptase p66/p51More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Science

Curated by ChEMBL
LigandPNGBDBM50478100(CHEMBL252036 | GS-9148)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of wild type HIV 3B reverse transcriptase in MT2 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Science

Curated by ChEMBL
LigandPNGBDBM50482144(CHEMBL1098407)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50350199(CHEMBL1814767)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of human ADK using [3H]-adenosine by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50350195(CHEMBL1814763)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of human ADK using [3H]-adenosine by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50199883(3,4‐Dichloroisocoumarin (2) | 3,4-Dichloro-i...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human leukocyte elastase using [14C]GS7340 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 6(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  3.00E+3nMAssay Description:TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetSolute carrier family 22 member 6(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM13066(2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid...)
Affinity DataIC50:  4.00E+3nMAssay Description:TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetSolute carrier family 22 member 6(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50485550(CHEBI:17859 | Glutarate)
Affinity DataIC50:  4.90E+3nMAssay Description:TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50350194(CHEMBL1814762)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human ADK using [3H]-adenosine by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50350204(CHEMBL1814773)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human ADK using [3H]-adenosine by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50350202(CHEMBL1814770)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human ADK using [3H]-adenosine by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50350201(CHEMBL1814769)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human ADK using [3H]-adenosine by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50350200(CHEMBL1814768)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human ADK using [3H]-adenosine by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50350198(CHEMBL1814766)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human ADK using [3H]-adenosine by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50350209(CHEMBL1814780)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human ADK using [3H]-adenosine by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Science

Curated by ChEMBL
LigandPNGBDBM50476385(CHEMBL229284)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Science

Curated by ChEMBL
LigandPNGBDBM50476387(CHEMBL229111)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50571531(Gs 441524 | Gs-441524 | Gs441524)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase using sshRNA template preincubated for 5 mins followed by compound addition and measured after 90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 6(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50339185((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...)
Affinity DataIC50:  5.80E+3nMAssay Description:TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetSolute carrier family 22 member 6(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50344964(Betamipron | CHEMBL1231530 | N-(phenylcarbonyl)-be...)
Affinity DataIC50:  6.00E+3nMAssay Description:TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSolute carrier family 22 member 6(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50206509(4-Dipropylsulfamoyl-benzoic acid | 4-Dipropylsulfa...)
Affinity DataIC50:  6.30E+3nMAssay Description:TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
TargetSolute carrier family 22 member 6(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50206509(4-Dipropylsulfamoyl-benzoic acid | 4-Dipropylsulfa...)
Affinity DataIC50:  7.40E+3nMAssay Description:TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
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