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Found 1265 with Last Name = 'codd' and Initial = 'ee'
TargetAlpha-2A adrenergic receptor [16-465](Rattus norvegicus (rat))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50085677(4-(1,3-Dimethyl-6,7-dihydro-benzo[c]thiophen-4-yl)...)
Affinity DataKi:  0.00860nMAssay Description:In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465](Rattus norvegicus (rat))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50085677(4-(1,3-Dimethyl-6,7-dihydro-benzo[c]thiophen-4-yl)...)
Affinity DataKi:  0.00860nMAssay Description:Binding affinity towards alpha-2D adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144258(4-[(8-Benzo[1,3]dioxol-5-ylmethyl-8-aza-bicyclo[3....)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity for delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50085683((+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole | 4...)
Affinity DataKi:  0.0150nMAssay Description:In vitro binding affinity against alpha-2 adrenergic receptor in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465](Rattus norvegicus (rat))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50085683((+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole | 4...)
Affinity DataKi:  0.0150nMAssay Description:In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465](Rattus norvegicus (rat))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50085683((+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole | 4...)
Affinity DataKi:  0.0150nMAssay Description:Binding affinity towards alpha-2D adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50085683((+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole | 4...)
Affinity DataKi:  0.0150nMAssay Description:In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144236(4-[(R)-(S)-8-Aza-bicyclo[3.2.1]oct-(3Z)-ylidene-ph...)
Affinity DataKi:  0.0230nMAssay Description:Binding affinity for delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144229(4-{[(1S,5R)-8-Allyl-8-aza-bicyclo[3.2.1]oct-(3Z)-y...)
Affinity DataKi:  0.0250nMAssay Description:Effective concentration against stimulation of [35S]-GTP-gammaS, binding in CHO cells transfected with the human opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50029246(1-[5-(4-Benzofuran-7-yl-piperazin-1-ylmethyl)-thio...)
Affinity DataKi:  0.0700nMAssay Description:Binding affinity was determined against 5-hydroxytryptamine 1A receptor using [3H]WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50370037(CHEMBL1744288)
Affinity DataKi:  0.0700nMAssay Description:In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50370036(CHEMBL1203855)
Affinity DataKi:  0.0700nMAssay Description:In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50370035(CHEMBL1788145)
Affinity DataKi:  0.0800nMAssay Description:In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50000787((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydr...)
Affinity DataKi:  0.0825nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50370026(CHEMBL1744273)
Affinity DataKi:  0.0880nMAssay Description:In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50370020(CHEMBL1744270)
Affinity DataKi:  0.0900nMAssay Description:In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50370021(CHEMBL1744272)
Affinity DataKi:  0.100nMAssay Description:In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50029326(8-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...)
Affinity DataKi:  0.130nMAssay Description:Affinity against the 5-hydroxytryptamine receptor 1A using [3H]WB-4101.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144281(CHEMBL63309 | N-Methyl-4-[(8-phenethyl-8-aza-bicyc...)
Affinity DataKi:  0.140nMAssay Description:In vitro binding affinity towards opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144284(CHEMBL68412 | N-Ethyl-4-[(3-hydroxy-phenyl)-(8-thi...)
Affinity DataKi:  0.152nMAssay Description:In vitro binding affinity towards opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50370019(CHEMBL1203846)
Affinity DataKi:  0.170nMAssay Description:In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50098334(4-[1-(3-Bromo-thiophen-2-yl)-ethyl]-1H-imidazole |...)
Affinity DataKi:  0.180nMAssay Description:In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity was determined against Dopamine receptor D2 using [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50155124(4-{Bromo-[(1S,5R)-8-furan-3-ylmethyl-8-aza-bicyclo...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity against mu opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088712(4-{[(1S,3S,5R)-8-(Benzo[1,3]dioxole-5-carbonyl)-8-...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of [3H]-DPDPE radioligand binding to rat opioid receptor delta 1 site from rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50029257((3-((4-(2-isopropoxyphenyl)piperazin-1-yl)methyl)p...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity towards alpha-1A adrenergic receptors using alpha1A ligand WB4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50064563(CHEMBL61816 | [3-(4-Benzofuran-6-yl-piperazin-1-yl...)
Affinity DataKi:  0.210nMAssay Description:Compound was evaluated for its binding affinity against 5-hydroxytryptamine 1A receptor from rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50016846((levallorphan)17-allyl-(1R,9R)-17-azatetracyclo[7....)
Affinity DataKi:  0.213nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144275(CHEMBL419621 | N-Ethyl-4-[(3-hydroxy-phenyl)-(8-ph...)
Affinity DataKi:  0.222nMAssay Description:In vitro binding affinity towards opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50370044(CHEMBL1744289)
Affinity DataKi:  0.230nMAssay Description:In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144249(CHEMBL302801 | N,N-Diethyl-4-{[(1S,5R)-8-phenethyl...)
Affinity DataKi:  0.240nMAssay Description:In vitro binding affinity towards opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144249(CHEMBL302801 | N,N-Diethyl-4-{[(1S,5R)-8-phenethyl...)
Affinity DataKi:  0.240nMAssay Description:Binding affinity for delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144291(CHEMBL67790 | N-Ethyl-4-[(4-hydroxy-phenyl)-(8-thi...)
Affinity DataKi:  0.25nMAssay Description:In vitro binding affinity towards opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50029262(Pentanoic acid {5-[4-(2-isopropoxy-phenyl)-piperaz...)
Affinity DataKi:  0.25nMAssay Description:Binding affinity was determined against 5-hydroxytryptamine 1A receptor using [3H]WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50155085(CHEMBL362331 | N,N-Diethyl-4-[(8-phenethyl-8-aza-b...)
Affinity DataKi:  0.260nMAssay Description:Binding affinity against mu opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144276(CHEMBL63651 | N-Ethyl-4-{[(1S,5R)-8-phenethyl-8-az...)
Affinity DataKi:  0.260nMAssay Description:In vitro binding affinity towards opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50370043(CHEMBL1744263)
Affinity DataKi:  0.280nMAssay Description:In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50370033(CHEMBL1744278)
Affinity DataKi:  0.290nMAssay Description:In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144234(4-((R)-(S)-8-Aza-bicyclo[3.2.1]oct-3-yl-phenyl-ami...)
Affinity DataKi:  0.300nMAssay Description:Effective concentration against stimulation of [35S]-GTP-gammaS, binding in CHO cells transfected with the human opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144246(4-{[(1R,5S)-8-Allyl-8-aza-bicyclo[3.2.1]oct-(3E)-y...)
Affinity DataKi:  0.320nMAssay Description:Binding affinity for delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50064537(CHEMBL293658 | {3-[4-(2,3-Dihydro-benzo[1,4]dioxin...)
Affinity DataKi:  0.340nMAssay Description:Compound was evaluated for its binding affinity against 5-hydroxytryptamine 1A receptor from rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50370023(CHEMBL1203850)
Affinity DataKi:  0.350nMAssay Description:In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465](Rattus norvegicus (rat))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50085679(4-(4,5,6,7-Tetrahydro-benzo[b]thiophen-7-yl)-1H-im...)
Affinity DataKi:  0.350nMAssay Description:In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465](Rattus norvegicus (rat))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50085679(4-(4,5,6,7-Tetrahydro-benzo[b]thiophen-7-yl)-1H-im...)
Affinity DataKi:  0.350nMAssay Description:Binding affinity towards alpha-2D adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144233(4-[(S)-(R)-8-Aza-bicyclo[3.2.1]oct-(3E)-ylidene-ph...)
Affinity DataKi:  0.360nMAssay Description:Binding affinity for delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  0.365nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.370nMAssay Description:Compound was evaluated for its binding affinity with Dopamine receptor D2 using membranes prepared from rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.370nMAssay Description:Binding affinity towards dopamine D2 receptors in rat brain synaptosomal preparationsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144240(CHEMBL65151 | N,N-Diethyl-4-{[8-(2-phenoxy-ethyl)-...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity for delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144282(4-[(8-Allyl-8-aza-bicyclo[3.2.1]oct-3-ylidene)-(3-...)
Affinity DataKi:  0.384nMAssay Description:In vitro binding affinity towards opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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