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Found 756 with Last Name = 'cowan' and Initial = 'd'
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50086433(CHEMBL3426034)
Affinity DataKi:  0.300nMAssay Description:Inhibition of wild type fully glycosylated human recombinant CD38-catalyzed NAD hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50086438(CHEMBL3426039)
Affinity DataKi:  0.450nMAssay Description:Inhibition of wild type fully glycosylated human recombinant CD38-catalyzed NAD hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50086434(CHEMBL3426035)
Affinity DataKi:  0.700nMAssay Description:Inhibition of wild type fully glycosylated human recombinant CD38-catalyzed NAD hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50063920((R)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-propy...)
Affinity DataKi:  2nMAssay Description:Inhibition of Matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50063920((R)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-propy...)
Affinity DataKi:  2nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103099((2R,3S)-3-(Formyl-hydroxy-amino)-2-isobutyl-pentan...)
Affinity DataKi:  11nMAssay Description:Inhibitionof Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50086425(CHEMBL3426030)
Affinity DataKi:  14nMAssay Description:Inhibition of wild type fully glycosylated human recombinant CD38-catalyzed NAD hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103097((2R,3S)-3-(Formyl-hydroxy-amino)-2-isobutyl-pentan...)
Affinity DataKi:  16nMAssay Description:Inhibition of Matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103097((2R,3S)-3-(Formyl-hydroxy-amino)-2-isobutyl-pentan...)
Affinity DataKi:  16nMAssay Description:Inhibitionof Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103096((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  17nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103102((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  17nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103092((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  17nMAssay Description:Inhibition of Matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103093((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  20nMAssay Description:Inhibitionof Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103098((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  20nMAssay Description:Inhibitionof Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103092((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  21nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103099((2R,3S)-3-(Formyl-hydroxy-amino)-2-isobutyl-pentan...)
Affinity DataKi:  24nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxo Wellcome Research

Curated by ChEMBL
LigandPNGBDBM50029954((7R,7aS)-7-(3-Cyclopentyloxy-4-methoxy-phenyl)-hex...)
Affinity DataKi:  27nMAssay Description:Inhibition of human Phosphodiesterase 4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103102((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  27nMAssay Description:Inhibitionof Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103098((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  27nMAssay Description:Inhibition of Matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103097((2R,3S)-3-(Formyl-hydroxy-amino)-2-isobutyl-pentan...)
Affinity DataKi:  28nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103093((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  29nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103095((2R,3S)-3-(Formyl-hydroxy-amino)-2-isobutyl-pentan...)
Affinity DataKi:  29nMAssay Description:Inhibitionof Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxo Wellcome Research

Curated by ChEMBL
LigandPNGBDBM50285059(1-(tert-butyl) 3-methyl 4-(3-cyclopentyloxy-4-meth...)
Affinity DataKi:  30nMAssay Description:Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB)More data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxo Wellcome Research

Curated by ChEMBL
LigandPNGBDBM50470745(CHEMBL286840)
Affinity DataKi:  30nMAssay Description:Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxo Wellcome Research

Curated by ChEMBL
LigandPNGBDBM50048248((3S,4R)-3-Acetyl-4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  30nMAssay Description:Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB)More data for this Ligand-Target Pair
In DepthDetails Article
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103101((2R,3S)-3-(Formyl-hydroxy-amino)-2-isobutyl-pentan...)
Affinity DataKi:  31nMAssay Description:Inhibitionof Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103100((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  33nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxo Wellcome Research

Curated by ChEMBL
LigandPNGBDBM50470752(CHEMBL38328)
Affinity DataKi:  34nMAssay Description:Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103098((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  34nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103102((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  36nMAssay Description:Inhibition of Matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103101((2R,3S)-3-(Formyl-hydroxy-amino)-2-isobutyl-pentan...)
Affinity DataKi:  38nMAssay Description:Inhibition of matrix metalloprotease-3 (MMP3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxo Wellcome Research

Curated by ChEMBL
LigandPNGBDBM50285045(1-isopropyl 3-methyl 4-(3-cyclopentyloxy-4-methoxy...)
Affinity DataKi:  40nMAssay Description:Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103093((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  41nMAssay Description:Inhibition of Matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103099((2R,3S)-3-(Formyl-hydroxy-amino)-2-isobutyl-pentan...)
Affinity DataKi:  42nMAssay Description:Inhibition of Matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103099((2R,3S)-3-(Formyl-hydroxy-amino)-2-isobutyl-pentan...)
Affinity DataKi:  45nMAssay Description:Inhibition of matrix metalloprotease-3 (MMP3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxo Wellcome Research

Curated by ChEMBL
LigandPNGBDBM50470756(CHEMBL37453)
Affinity DataKi:  46nMAssay Description:Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103095((2R,3S)-3-(Formyl-hydroxy-amino)-2-isobutyl-pentan...)
Affinity DataKi:  47nMAssay Description:Inhibition of Matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxo Wellcome Research

Curated by ChEMBL
LigandPNGBDBM50285042(CHEMBL302632 | tert-butyl 3-(3-cyclopentyloxy-4-me...)
Affinity DataKi:  50nMAssay Description:Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB)More data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxo Wellcome Research

Curated by ChEMBL
LigandPNGBDBM50285038(1-benzyl 3-methyl 4-(3-cyclopentyloxy-4-methoxyphe...)
Affinity DataKi:  50nMAssay Description:Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103101((2R,3S)-3-(Formyl-hydroxy-amino)-2-isobutyl-pentan...)
Affinity DataKi:  55nMAssay Description:Inhibition of Matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103096((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  55nMAssay Description:Inhibitionof Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxo Wellcome Research

Curated by ChEMBL
LigandPNGBDBM50470750(CHEMBL286291)
Affinity DataKi:  56nMAssay Description:Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxo Wellcome Research

Curated by ChEMBL
LigandPNGBDBM50470731(CHEMBL146946)
Affinity DataKi:  59nMAssay Description:Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxo Wellcome Research

Curated by ChEMBL
LigandPNGBDBM50470736(CHEMBL37029)
Affinity DataKi:  60nMAssay Description:Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxo Wellcome Research

Curated by ChEMBL
LigandPNGBDBM50285050(CHEMBL59386 | methyl 3-(3-cyclopentyloxy-4-methoxy...)
Affinity DataKi:  60nMAssay Description:Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB)More data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxo Wellcome Research

Curated by ChEMBL
LigandPNGBDBM50029955((7R,7aR)-7-(3-Cyclopentyloxy-4-methoxy-phenyl)-hex...)
Affinity DataKi:  63nMAssay Description:Inhibition of human Phosphodiesterase 4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103094((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  64nMAssay Description:Inhibitionof Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxo Wellcome Research

Curated by ChEMBL
LigandPNGBDBM50470740(CHEMBL264851)
Affinity DataKi:  65nMAssay Description:Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxo Wellcome Research

Curated by ChEMBL
LigandPNGBDBM50470754(CHEMBL288928)
Affinity DataKi:  68nMAssay Description:Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxo Wellcome Research

Curated by ChEMBL
LigandPNGBDBM50029951((7R,7aS)-7-(3-Cyclopentyloxy-4-methoxy-phenyl)-tet...)
Affinity DataKi:  70nMAssay Description:Inhibition of human Phosphodiesterase 4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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